Publications by authors named "Adrian Simon"

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Dedifferentiated Solitary Fibrous Tumor: A Clinicopathologic, Immunohistochemical, and Molecular Characterization of 25 Cases.
Adrian Georg Simon, Adrian Mariño-Enríquez, Jason L Hornick, Christopher D M Fletcher, William J Anderson

Am J Surg Pathol· October 2025

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CSF1R myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma.
David Stahl, Philipp Gödel, Hyatt Balke-Want, Rahil Gholamipoorfard, Paul Segbers, Adrian G Simon

Cancer Cell· August 2025

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The expression of the tight junction protein and therapeutical target Claudin 18.2 is heterogeneously distributed within esophageal and gastric adenocarcinoma.
Svetlana Pak, Adrian Georg Simon, Su Ir Lyu, Yuri Tolkach, Hakan Alakus

Sci Rep· August 2025

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Basal-like subtype of esophageal adenocarcinoma and it's morphological, molecular and clinical characteristics.
Su Ir Lyu, Caroline Fretter, Axel M Hillmer, Bastian Grothey, Sascha Hoppe, Adrian Georg Simon

Sci Rep· July 2025

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Exploration of histone protein γ-H2AX as a prognostic factor in soft tissue sarcomas and its association with biological behavior, immune cell environment and survival in leiomyosarcoma.
Adrian Georg Simon, Su Ir Lyu, Anne Maria Schultheis, David Stahl, Nora Wuerdemann

Int J Cancer· June 2025

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Deep learning-based interpretable prediction of recurrence of diffuse large B-cell lymphoma.
Hussein Naji, Paul Hahn, Juan I Pisula, Stefano Ugliano, Adrian Simon

BJC Rep· May 2025

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Proteomic characterization of MET-amplified esophageal adenocarcinomas reveals enrichment of alternative splicing- and androgen signaling-related proteins.
Bastian Grothey, Su Ir Lyu, Alexander Quaas, Adrian Georg Simon, Jin-On Jung

Cell Mol Life Sci· March 2025

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High expression of H2AX/γ-H2AX is associated with distinct biological pathway alterations and shorter survival in oropharyngeal squamous cell carcinoma.
Su Ir Lyu, Caroline Fretter, Hans Nikolaus Caspar Eckel, Karl Knipper, Anne Maria Schultheis, Adrian Georg Simon

Oral Oncol· February 2025

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Extra-abdominal and intra-abdominal FET::CREM fusion mesenchymal neoplasms: comparative clinicopathological study of 9 new cases further supporting a distinct potentially aggressive sarcoma and report of novel sites.
Abbas Agaimy, Morgan Blakely, Gerben E Breimer, Annett Hölsken, Sjors A Koppes, Adrian G Simon

Virchows Arch· December 2024

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Therapy-relevant amplification in cholangiocarcinomas in Caucasian patients.
Su Ir Lyu, Patrick Sven Plum, Caroline Fretter, Adrian Georg Simon, Tillmann Bedau

Ther Adv Med Oncol· November 2024

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Hexokinase 2 as an independent risk factor for worse patient survival in esophageal adenocarcinoma and as a potential therapeutic target protein: A retrospective, single‑center cohort study.
Su Ir Lyu, Adrian Georg Simon, Jin-On Jung, Caroline Fretter, Wolfgang SchrÖder

Oncol Lett· October 2024

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Extent and clinical significance of the therapy-relevant tight junction protein Claudin 18.2 in pancreatic ductal adenocarcinoma - real-world evidence.
Su Ir Lyu, Caroline Fretter, Adrian Georg Simon, Sarah-Michele Spielmann, Alexander I Damanakis

Transl Oncol· September 2024

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Utilising activity patterns of a complex biophysical network model to optimise intra-striatal deep brain stimulation.
Konstantinos Spiliotis, Revathi Appali, Anna Karina Fontes Gomes, Jan Philipp Payonk, Simon Adrian

Sci Rep· August 2024

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Fetal gut cell-like differentiation in esophageal adenocarcinoma defines a rare tumor subtype with therapeutically relevant claudin-6 positivity and SWI/SNF gene alteration.
Max Kraemer, Thomas Zander, Hakan Alakus, Reinhard Buettner, Su Ir Lyu, Adrian Georg Simon

Sci Rep· June 2024

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HoLy-Net: Segmentation of histological images of diffuse large B-cell lymphoma.
Hussein Naji, Lucas Sancere, Adrian Simon, Reinhard Büttner, Marie-Lisa Eich

Comput Biol Med· March 2024

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Upregulation of the histone γ-H2AX correlates with worse patient survival and basal-like subtype in pancreatic ductal adenocarcinoma.
Karl Knipper, Yussra Hussein, Adrian Georg Simon, Caroline Fretter, Alexander I Damanakis

J Cancer Res Clin Oncol· March 2024

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An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL.
Lars Fabian Prinz, Tobias Riet, Daniel Felix Neureuther, Simon Lennartz, Danuta Chrobok, Adrian Georg Simon

Cell Rep Med· February 2024

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Co-expression patterns of cancer associated fibroblast markers reveal distinct subgroups related to patient survival in oropharyngeal squamous cell carcinoma.
Su Ir Lyu, Jannik Johannsen, Adrian Georg Simon, Karl Knipper, Nora Wuerdemann

Front Cell Dev Biol· January 2024

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Copy-number-gain of telomerase reverse transcriptase (hTERT) is associated with an unfavorable prognosis in esophageal adenocarcinoma.
Su Ir Lyu, Felix C Popp, Adrian Georg Simon, Anne Maria Schultheis, Thomas Zander

Sci Rep· October 2023

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Dissecting the inflammatory tumor microenvironment of esophageal adenocarcinoma: mast cells and natural killer cells are favorable prognostic factors and associated with less extensive disease.
Alyne Condurú Dos Santos Cunha, Adrian Georg Simon, Thomas Zander, Reinhard Buettner, Christiane Josephine Bruns

J Cancer Res Clin Oncol· August 2023

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Syndecan‑1 expression is an independent favourable prognostic marker in oesophageal adenocarcinoma and represents a potential therapeutic target.
Duygu Akca, Adrian Simon, Reinhard Buettner, Christiane Bruns, Wolfgang Schroeder

Oncol Lett· August 2023

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The tight junction protein claudin 6 is a potential target for patient-individualized treatment in esophageal and gastric adenocarcinoma and is associated with poor prognosis.
Adrian Georg Simon, Su Ir Lyu, Mark Laible, Stefan Wöll, Özlem Türeci

J Transl Med· August 2023

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High NANOG expression correlates with worse patients' survival in esophageal adenocarcinoma.
Karl Knipper, Alexander I Damanakis, Su Ir Lyu, Adrian Georg Simon, Isabell Wahler

BMC Cancer· July 2023

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RNA Sequencing Reveals Alterations and Similarities in Cell Metabolism, Hypoxia and Immune Evasion in Primary Cell Cultures of Clear Cell Renal Cell Carcinoma.
Adrian Georg Simon, Laura Kristin Esser, Jörg Ellinger, Manuel Ritter, Glen Kristiansen

Front Oncol· May 2022

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Overexpression of Parkin in clear cell renal cell carcinoma decreases tumor aggressiveness by regulating CKS2 levels.
Laura Kristin Esser, Vittorio Branchi, Farhad Shakeri, Adrian Georg Simon, Carsten Stephan

Int J Oncol· February 2022

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