Publications by authors named "Adrienne A Tymiak"

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Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry.
Richard Y-C Huang, Roxana E Iacob, Sethu Sankaranarayanan, Ling Yang, Michael Ahlijanian, Adrienne A Tymiak

J Am Soc Mass Spectrom· January 2018

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Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL-6 Receptor upon Binding of Protein Therapeutics.
Ke Sherry Li, Guodong Chen, Jingjie Mo, Richard Y-C Huang, Ekaterina G Deyanova, Adrienne A Tymiak

Anal Chem· July 2017

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Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry.
Richard Y-C Huang, Roxana E Iacob, Stanley R Krystek, Mi Jin, Hui Wei, Adrienne A Tymiak

J Am Soc Mass Spectrom· May 2017

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Tiered analytics for purity assessment of macrocyclic peptides in drug discovery: Analytical consideration and method development.
Jingfang Jenny Qian Cutrone, Xiaohua Stella Huang, Edward S Kozlowski, Ye Bao, Yingzi Wang, Adrienne A Tymiak

J Pharm Biomed Anal· May 2017

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The role of chromatographic and chiroptical spectroscopic techniques and methodologies in support of drug discovery for atropisomeric drug inhibitors of Bruton's tyrosine kinase.
Jun Dai, Chunlei Wang, Sarah C Traeger, Lorell Discenza, Mary T Obermeier, Adrienne A Tymiak

J Chromatogr A· March 2017

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Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis.
Jing Li, Hui Wei, Stanley R Krystek, Derek Bond, Ty M Brender, Adrienne A Tymiak

Anal Chem· February 2017

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Chromatography-based methods for determining molar extinction coefficients of cytotoxic payload drugs and drug antibody ratios of antibody drug conjugates.
Chunlei Wang, Sike Chen, Janet Caceres-Cortes, Richard Y-C Huang, Adrienne A Tymiak

J Chromatogr A· July 2016

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Characterization and quantification of histidine degradation in therapeutic protein formulations by size exclusion-hydrophilic interaction two dimensional-liquid chromatography with stable-isotope labeling mass spectrometry.
Chunlei Wang, Sike Chen, John A Brailsford, Aaron P Yamniuk, Adrienne A Tymiak

J Chromatogr A· December 2015

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Utility of Ion Mobility Mass Spectrometry for Drug-to-Antibody Ratio Measurements in Antibody-Drug Conjugates.
Richard Y-C Huang, Ekaterina G Deyanova, David Passmore, Vangipuram Rangan, Shrikant Deshpande, Adrienne A Tymiak

J Am Soc Mass Spectrom· October 2015

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Correction to "Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development".
Scott A Shaw, Balu Balasubramanian, Samuel Bonacorsi, Janet Caceres Cortes, Kevin Cao, Adrienne A Tymiak

J Org Chem· September 2015

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Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development.
Scott A Shaw, Balu Balasubramanian, Samuel Bonacorsi, Janet Caceres Cortes, Kevin Cao, Adrienne A Tymiak

J Org Chem· July 2015

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Metabolomics in the pharmaceutical industry.
Michael D Reily, Adrienne A Tymiak

Drug Discov Today Technol· June 2015

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Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics.
Roxana E Iacob, Stanley R Krystek, Richard Y-C Huang, Hui Wei, Li Tao, Adrienne A Tymiak

Expert Rev Proteomics· April 2015

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The influence of adnectin binding on the extracellular domain of epidermal growth factor receptor.
Roxana E Iacob, Guodong Chen, Joomi Ahn, Stephane Houel, Hui Wei, Adrienne A Tymiak

J Am Soc Mass Spectrom· December 2014

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Fast photochemical oxidation of proteins (FPOP) maps the epitope of EGFR binding to adnectin.
Yuetian Yan, Guodong Chen, Hui Wei, Richard Y-C Huang, Jingjie Mo, Adrienne A Tymiak

J Am Soc Mass Spectrom· December 2014

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Development of a highly sensitive liquid chromatography/tandem mass spectrometry method to quantify total and free levels of a target protein, interferon-gamma-inducible protein-10, at picomolar levels in human serum.
Hongwei Zhang, Qing Xiao, Baomin Xin, Wendy Trigona, Adrienne A Tymiak

Rapid Commun Mass Spectrom· July 2014

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Optimization and simulation of tandem column supercritical fluid chromatography separations using column back pressure as a unique parameter.
Chunlei Wang, Adrienne A Tymiak, Yingru Zhang

Anal Chem· April 2014

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Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications.
Hui Wei, Jingjie Mo, Li Tao, Reb J Russell, Adrienne A Tymiak

Drug Discov Today· January 2014

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Characterization of disulfide linkages in recombinant human granulocyte-colony stimulating factor.
Jingjie Mo, Adrienne A Tymiak, Guodong Chen

Rapid Commun Mass Spectrom· May 2013

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High-resolution MS for structural characterization of protein therapeutics: advances and future directions.
Hui Wei, Adrienne A Tymiak, Guodong Chen

Bioanalysis· May 2013

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Structural mass spectrometry in biologics discovery: advances and future trends.
Jingjie Mo, Adrienne A Tymiak, Guodong Chen

Drug Discov Today· December 2012

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Quantitation of therapeutic proteins following direct trypsin digestion of dried blood spot samples and detection by LC-MS-based bioanalytical methods in drug discovery.
Bogdan G Sleczka, Celia J D'Arienzo, Adrienne A Tymiak, Timothy V Olah

Bioanalysis· January 2012

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Approach to evaluating dried blood spot sample stability during drying process and discovery of a treated card to maintain analyte stability by rapid on-card pH modification.
Guowen Liu, Qin C Ji, Mohammed Jemal, Adrienne A Tymiak, Mark E Arnold

Anal Chem· December 2011

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Characterization of protein therapeutics by mass spectrometry: recent developments and future directions.
Guodong Chen, Bethanne M Warrack, Angela K Goodenough, Hui Wei, David B Wang-Iverson, Adrienne A Tymiak

Drug Discov Today· January 2011

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A tris (2-carboxyethyl) phosphine (TCEP) related cleavage on cysteine-containing proteins.
Peiran Liu, Brian W O'Mara, Bethanne M Warrack, Wei Wu, Yunping Huang, Adrienne A Tymiak

J Am Soc Mass Spectrom· May 2010

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