Publications by authors named "Aki Kohyama"

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Synthesis and Properties of Medium-Sized -Cycloocta-1,3-diene-Pt(II) Complexes.
Hayate Kinouchi, Tomohiro Ito, Aki Kohyama, Yusuke Kuroda, Hiroshi Takikawa

Org Lett· December 2025

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A Potassium Base-Promoted Intramolecular Enolate-Olefin Metathesis.
Kazuma Sugimoto, Takaaki Nagao, Kazuma Kurokawa, Tsukasa Tawatari, Yasunori Miyakawa, Aki Kohyama

Chemistry· October 2025

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In-cell proximity target validation methods for heterobifunctional molecules with CRBN- or VHL-binder using AirID.
Kohdai Yamada, Satoshi Yamanaka, Hiroyuki Yamakoshi, Aki Kohyama, Yoshiharu Iwabuchi

Commun Biol· August 2025

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Room-Temperature Ligation of Iminophosphoranes with -Difluoroalkenes.
Masaru Tanioka, Fuudai Enomoto, Fumino Kitamura, Ryunosuke Nakamura, Akinari Takano, Aki Kohyama

J Org Chem· March 2025

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Water-Compatible Staudinger-Diels-Alder Ligation.
Masaru Tanioka, Shohei Kanayama, Fumino Kitamura, Akinari Takano, Yukiko Ikeda, Aki Kohyama

J Org Chem· January 2025

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Design, Synthesis, and Biological Evaluation of Water-Soluble Prodrugs of C5-Curcuminoid GO-Y030 Based on Reversible Thia-Michael Reaction.
Hiroyuki Yamakoshi, Michihiro Fukuda, Hiro Ikeda, Shogo Fujiki, Aki Kohyama

Chem Pharm Bull (Tokyo)· February 2024

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Ratiometric analysis of reversible thia-Michael reactions using nitrile-tagged molecules by Raman microscopy.
Hiroyuki Yamakoshi, Daiki Shibata, Kazuki Bando, Shinji Kajimoto, Aki Kohyama

Chem Commun (Camb)· December 2023

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Controllable conformation and reactivity of bicyclic α-methylene cyclopentanones and their NF-κB pathway inhibitory activity.
Aki Kohyama, Aya Shiuchi, Yue Zhou, Masaru Tanioka, Kenji Sugimoto

Org Biomol Chem· June 2023

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Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate.
Aki Kohyama, Min Jo Kim, Rei Yokoyama, Sijia Sun, Ashraf M Omar

Bioorg Med Chem· January 2022

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Synthetic E-guggulsterone derivative GSD-1 inhibits NF-κB signaling and suppresses the metastatic potential of breast cancer cells.
Amira A Abdellatef, Yue Zhou, Akane Yamada, Sahar A Elmekkawy, Aki Kohyama

Biomed Pharmacother· August 2021

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Divinylcarbinol Desymmetrization Strategy: A Concise and Reliable Approach to Chiral Hydroxylated Fatty Acid Derivatives.
Kenji Sugimoto, Ami Kobayashi, Aki Kohyama, Haruka Sakai, Yuji Matsuya

J Org Chem· March 2021

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Synthesis of guggulsterone derivatives as potential anti-austerity agents against PANC-1 human pancreatic cancer cells.
Aki Kohyama, Rei Yokoyama, Dya Fita Dibwe, Sahar El-Mekkawy, Meselhy R Meselhy

Bioorg Med Chem Lett· April 2020

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Facile o-quinodimethane formation from benzocyclobutenes triggered by the Staudinger reaction at ambient temperature.
Aki Kohyama, Eri Koresawa, Kiyoshi Tsuge, Yuji Matsuya

Chem Commun (Camb)· May 2019

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A Curcumin Analog, GO-Y078, Effectively Inhibits Angiogenesis through Actin Disorganization.
Shunsuke Sugiyama, Yuki Yoshino, Sei Kuriyama, Masahiro Inoue, Keigo Komine, Aki Kohyama

Anticancer Agents Med Chem· December 2016

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Reversibility of the thia-Michael reaction of cytotoxic C-curcuminoid and structure-activity relationship of bis-thiol-adducts thereof.
Aki Kohyama, Michihiro Fukuda, Shunsuke Sugiyama, Hiroyuki Yamakoshi, Naoki Kanoh

Org Biomol Chem· December 2016

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Identification of anti-cancer chemical compounds using Xenopus embryos.
Masamitsu Tanaka, Sei Kuriyama, Go Itoh, Aki Kohyama, Yoshiharu Iwabuchi

Cancer Sci· June 2016

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Structure-Activity Relationships of the Antitumor C5-Curcuminoid GO-Y030.
Aki Kohyama, Hiroyuki Yamakoshi, Shoko Hongo, Naoki Kanoh, Hiroyuki Shibata

Molecules· August 2015

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