Publications by authors named "Akil Omar"

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Cochlear gene therapy restores hearing and auditory processing in an atypical DFNB9 mouse model.
Najate Benamer, Hélène Le Ribeuz, Chloé Felgerolle, Charlotte Calvet, Olivier Postal, Omar Akil

Commun Med (Lond)· June 2025

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End-Stage Achalasia With Megaesophagus Refractory to Two Heller Myotomies.
Lorraine I Chong Tai, Omar Akil, Kimberly Q Nguyen, Aryama Sharma

Cureus· March 2024

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Dual and triple AAV delivery of large therapeutic gene sequences into the inner ear.
Omar Akil

Hear Res· September 2020

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Neurotrophin gene therapy to promote survival of spiral ganglion neurons after deafness.
Patricia A Leake, Omar Akil, Hainan Lang

Hear Res· September 2020

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Trophic factors are essential for the survival of grafted oligodendrocyte progenitors and for neuroprotection after perinatal excitotoxicity.
Megumi Hirose-Ikeda, Brian Chu, Paul Zhao, Omar Akil, Elida Escalante

Neural Regen Res· March 2020

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Clarin-1 expression in adult mouse and human retina highlights a role of Müller glia in Usher syndrome.
Lei Xu, Susan N Bolch, Clayton P Santiago, Frank M Dyka, Omar Akil

J Pathol· February 2020

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Cochlear Gene Therapy.
Lawrence Lustig, Omar Akil

Cold Spring Harb Perspect Med· September 2019

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AAV-Mediated Neurotrophin Gene Therapy Promotes Improved Survival of Cochlear Spiral Ganglion Neurons in Neonatally Deafened Cats: Comparison of AAV2-hBDNF and AAV5-hGDNF.
Patricia A Leake, Stephen J Rebscher, Chantale Dore', Omar Akil

J Assoc Res Otolaryngol· August 2019

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AAV-Mediated Gene Delivery to the Inner Ear.
Omar Akil, Lawrence Lustig

Methods Mol Biol· July 2019

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Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model.
Omar Akil, Frank Dyka, Charlotte Calvet, Alice Emptoz, Ghizlene Lahlou

Proc Natl Acad Sci U S A· March 2019

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Cellular Dynamics in Early Healing of Mouse Tympanic Membranes.
Divya A Chari, Stacey M Frumm, Omar Akil, Aaron D Tward

Otol Neurotol· February 2019

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Virally Mediated Overexpression of Glial-Derived Neurotrophic Factor Elicits Age- and Dose-Dependent Neuronal Toxicity and Hearing Loss.
Omar Akil, Bas Blits, Lawrence R Lustig, Patricia A Leake

Hum Gene Ther· January 2019

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Deletion of Tmtc4 activates the unfolded protein response and causes postnatal hearing loss.
Jiang Li, Omar Akil, Stephanie L Rouse, Conor W McLaughlin, Ian R Matthews

J Clin Invest· November 2018

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Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome.
Didier Dulon, Samantha Papal, Pranav Patni, Matteo Cortese, Philippe Fy Vincent, Omar Akil

J Clin Invest· August 2018

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Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development.
Ilia D Vainchtein, Gregory Chin, Frances S Cho, Kevin W Kelley, John G Miller, Omar Akil

Science· March 2018

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Modeling and Preventing Progressive Hearing Loss in Usher Syndrome III.
Ruishuang Geng, Akil Omar, Suhasini R Gopal, Daniel H-C Chen, Ruben Stepanyan

Sci Rep· October 2017

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Local gene therapy durably restores vestibular function in a mouse model of Usher syndrome type 1G.
Alice Emptoz, Vincent Michel, Andrea Lelli, Omar Akil, Jacques Boutet de Monvel

Proc Natl Acad Sci U S A· September 2017

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Parallel mechanisms suppress cochlear bone remodeling to protect hearing.
Emmanuel J Jáuregui, Omar Akil, Claire Acevedo, Faith Hall-Glenn, Betty S Tsai

Bone· August 2016

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Mouse Auditory Brainstem Response Testing.
Omar Akil, A E Oursler, Kevin Fan, Lawrence R Lustig

Bio Protoc· March 2016

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Role of saposin C and D in auditory and vestibular function.
Lawrence R Lustig, Sean Alemi, Ying Sun, Gregory Grabowski, Omar Akil

Laryngoscope· February 2016

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Surgical method for virally mediated gene delivery to the mouse inner ear through the round window membrane.
Omar Akil, Stephanie L Rouse, Dylan K Chan, Lawrence R Lustig

J Vis Exp· March 2015

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Spiral ganglion degeneration and hearing loss as a consequence of satellite cell death in saposin B-deficient mice.
Omar Akil, Ying Sun, Sarath Vijayakumar, Wujuan Zhang, Tiffany Ku

J Neurosci· February 2015

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Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia.
Omar Akil, Faith Hall-Glenn, Jolie Chang, Alfred Li, Wenhan Chang

PLoS One· December 2014

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Mouse Cochlear Whole Mount Immunofluorescence.
Omar Akil, Lawrence R Lustig

Bio Protoc· March 2013

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Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy.
Omar Akil, Rebecca P Seal, Kevin Burke, Chuansong Wang, Aurash Alemi

Neuron· July 2012

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