Publications by authors named "Akio Osa"

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Single-cell spatial analysis identifies ID1-high endothelial cells in tertiary lymphoid structures as predictors of durable response to immunotherapy in non-small cell lung cancer.
Kinnosuke Matsumoto, Yoshimi Noda, Kensuke Hachiya, Fumitaka Muramatsu, Naoki Okamoto, Osamu Morimura, Akio Osa

Cancer Cell Int· January 2026

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Long-term survival comparison of first-line pembrolizumab versus pembrolizumab plus chemotherapy for patients with advanced non-small cell lung cancer: A multicenter propensity-matched cohort study.
Nao Shoshihara, Kinnosuke Matsumoto, Takayuki Shiroyama, Kiyohide Komuta, Akito Miyazaki, Akio Osa

Lung Cancer· December 2025

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A Multicenter, Retrospective, Real-World Study of Atezolizumab Plus Chemotherapy and Pembrolizumab Plus Chemotherapy for Older Patients With NSCLC.
Kensuke Kanaoka, Kinnosuke Matsumoto, Takayuki Shiroyama, Akihiro Tsukaguchi, Nao Shoshihara, Osamu Morimura, Akio Osa

JTO Clin Res Rep· November 2025

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Real-world outcomes of nivolumab plus ipilimumab and pembrolizumab with platinum-based chemotherapy in advanced non-small cell lung cancer: a multicenter retrospective comparative study.
Kinnosuke Matsumoto, Takayuki Shiroyama, Motohiro Tamiya, Toshiyuki Minami, Yuhei Kinehara, Osamu Morimura, Akio Osa

Cancer Immunol Immunother· January 2024

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A randomized phase 2 study on demeclocycline in patients with mild-to-moderate COVID-19.
Kota Iwahori, Takuro Nii, Norihiko Yamaguchi, Takahiro Kawasaki, Satomi Okamura, Akio Osa

Sci Rep· August 2023

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Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8 T cell cytotoxicity and proliferation.
Yujiro Naito, Shohei Koyama, Kentaro Masuhiro, Takashi Hirai, Takeshi Uenami, Akio Osa

Sci Adv· May 2023

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Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer.
Kentaro Masuhiro, Motohiro Tamiya, Kosuke Fujimoto, Shohei Koyama, Yujiro Naito, Akio Osa

JCI Insight· May 2022

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IL-33 Induces Sema4A Expression in Dendritic Cells and Exerts Antitumor Immunity.
Yasuhiko Suga, Izumi Nagatomo, Yuhei Kinehara, Shohei Koyama, Daisuke Okuzaki, Akio Osa

J Immunol· September 2021

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Diffuse Pulmonary Cysts in Metastatic Angiosarcoma.
Takayuki Takimoto, Akio Osa, Satomu Morita, Kinya Abe

Intern Med· February 2020

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Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood.
Yujiro Naito, Akio Osa, Kentaro Masuhiro, Takashi Hirai, Shohei Koyama

J Vis Exp· February 2020

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Monitoring antibody binding to T cells in a pembrolizumab-treated patient with lung adenocarcinoma on hemodialysis.
Akio Osa, Takeshi Uenami, Yujiro Naito, Haruhiko Hirata, Shohei Koyama

Thorac Cancer· November 2019

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Lipid nanoparticles of Type-A CpG D35 suppress tumor growth by changing tumor immune-microenvironment and activate CD8 T cells in mice.
Lisa Munakata, Yoshihiko Tanimoto, Akio Osa, Jie Meng, Yasunari Haseda

J Control Release· November 2019

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Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells.
Yuhei Kinehara, Izumi Nagatomo, Shohei Koyama, Daisuke Ito, Satoshi Nojima, Akio Osa, Osamu Morimura

JCI Insight· December 2018

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Clinical implications of monitoring nivolumab immunokinetics in non-small cell lung cancer patients.
Akio Osa, Takeshi Uenami, Shohei Koyama, Kosuke Fujimoto, Daisuke Okuzaki

JCI Insight· October 2018

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Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade.
Esra A Akbay, Shohei Koyama, Yan Liu, Ruben Dries, Lauren E Bufe, Akio Osa

J Thorac Oncol· August 2017

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Trastuzumab emtansine suppresses the growth of HER2-positive small-cell lung cancer in preclinical models.
Osamu Morimura, Toshiyuki Minami, Takashi Kijima, Shohei Koyama, Tomoyuki Otsuka, Akio Osa

Biochem Biophys Res Commun· July 2017

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Successful treatment with gefitinib after Stevens-Johnson syndrome associated with afatinib therapy in a patient with adenocarcinoma of the lung.
Tomoyuki Otsuka, Aya Tanaka, Hiroaki Azukizawa, Shoko Sasaki, Mikako Ishijima, Akio Osa

Int Cancer Conf J· January 2017

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Nanoparticle Albumin-bound Paclitaxel+Carboplatin Therapy for Small Cell Lung Cancer Combined with Squamous Cell Carcinoma and Interstitial Lung Disease.
Yuichiro Azuma, Motohiro Tamiya, Takayuki Shiroyama, Akio Osa, Sawa Takeoka

Intern Med· July 2016

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A Rare Case of Pleomorphic Carcinoma of the Lung Harboring an Anaplastic Lymphoma Kinase (ALK) Rearrangement.
Takayuki Shiroyama, Ayako Tanaka, Motohiro Tamiya, Masanari Hamaguchi, Akio Osa

Intern Med· May 2016

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Relationship between progression-free survival and overall survival in patients with advanced non-small cell lung cancer treated with anticancer agents after first-line treatment failure.
Hidekazu Suzuki, Tomonori Hirashima, Norio Okamoto, Tadahiro Yamadori, Motohiro Tamiya, Akio Osa

Asia Pac J Clin Oncol· June 2015

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[Denosumab for bone metastasis of thoracic tumors-preparation of a practice manual and evaluation of its effectiveness].
Yoko Kondo, Motohiro Tamiya, Tomonori Hirashima, Noriko Ryota, Masumi Sando, Akio Osa

Gan To Kagaku Ryoho· November 2014

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Stratification of malignant pleural mesothelioma prognosis using recursive partitioning analysis.
Hidekazu Suzuki, Kazuhiro Asami, Tomonori Hirashima, Norio Okamoto, Tadahiro Yamadori, Akio Osa

Lung· February 2014

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Tubular nephrotoxicity induced by docetaxel in non-small-cell lung cancer patients.
Takayuki Takimoto, Tasuku Nakabori, Akio Osa, Satomu Morita, Haruko Terada

Int J Clin Oncol· August 2012

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Tension pneumomediastinum in a patient with interstitial pneumonia.
Takayuki Takimoto, Satomu Morita, Akio Osa, Kinya Abe

Intern Med· May 2012

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[A case of locally advanced non-small-cell lung cancer complicated with chronic renal failure and gastric cancer, successfully treated with weekly docetaxel and concurrent thoracic radiotherapy].
Takayuki Takimoto, Akane Watanabe, Tasuku Nakabori, Akio Osa, Satomu Morita

Gan To Kagaku Ryoho· September 2011

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