Publications by authors named "Alain J Labro"

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Oxygen Handling Practices for in Vitro Human Pluripotent Stem Cell Cardiomyocyte Differentiation: A Scoping Literature Review.
Lisse Frans, Jeffrey Aalders, Jolanda van Hengel, Alain J Labro

Stem Cell Rev Rep· October 2025

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Evaluating the proarrhythmic risk of delayed-action compounds in serum free cell culture conditions; serum-starvation accelerates/amplifies the effect of probucol on the KCNQ1 + KCNE1 channel.
Kenny M Van Theemsche, Lisse Frans, Dieter V Van de Sande, Evelyn Martinez-Morales, Dirk J Snyders, Alain J Labro

J Pharmacol Toxicol Methods· December 2024

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Immunosuppressive effects of new thiophene-based K1.3 inhibitors.
Špela Gubič, Alberto Montalbano, Cesare Sala, Andrea Becchetti, Louise Antonia Hendrickx, Alain J Labro

Eur J Med Chem· November 2023

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Correction: Gubič et al. Design of New Potent and Selective Thiophene-Based K1.3 Inhibitors and Their Potential for Anticancer Activity. 2022, , 2595.
Špela Gubič, Louise Antonia Hendrickx, Xiaoyi Shi, Žan Toplak, Štefan Možina, Alain J Labro

Cancers (Basel)· May 2023

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Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population.
Ewa Sieliwonczyk, Maaike Alaerts, Eline Simons, Dirk Snyders, Aleksandra Nijak, Alain J Labro

Orphanet J Rare Dis· January 2023

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A Possible Explanation for the Low Penetrance of Pathogenic KCNE1 Variants in Long QT Syndrome Type 5.
Szilvia Déri, Teodóra Hartai, László Virág, Norbert Jost, Alain J Labro

Pharmaceuticals (Basel)· December 2022

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The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels.
Laura Coonen, Evelyn Martinez-Morales, Dieter V Van De Sande, Dirk J Snyders, D Marien Cortes, Alain J Labro

Sci Adv· September 2022

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Design of New Potent and Selective Thiophene-Based K1.3 Inhibitors and Their Potential for Anticancer Activity.
Špela Gubič, Louise Antonia Hendrickx, Xiaoyi Shi, Žan Toplak, Štefan Možina, Alain J Labro

Cancers (Basel)· May 2022

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Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes.
Aleksandra Nijak, Eline Simons, Bert Vandendriessche, Dieter Van de Sande, Erik Fransen, Alain J Labro

Biol Open· February 2022

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The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells.
Dieter V Van de Sande, Ivan Kopljar, Alaerts Maaike, Ard Teisman, David J Gallacher, Alain J Labro

Channels (Austin)· December 2021

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Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the Inflammatory Cytokine IL-6 and Is Dependent on NF-κB Signaling.
Rohit Arora, Kenny M Van Theemsche, Samuel Van Remoortel, Dirk J Snyders, Alain J Labro

Int J Mol Sci· December 2021

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Developmental Toxicity and Biotransformation of Two Anti-Epileptics in Zebrafish Embryos and Early Larvae.
Chloé Bars, Jente Hoyberghs, Allan Valenzuela, Laura Buyssens, Miriam Ayuso, Alain J Labro

Int J Mol Sci· November 2021

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Impaired cytoplasmic domain interactions cause co-assembly defect and loss of function in the p.Glu293Lys KNCJ2 variant isolated from an Andersen-Tawil syndrome patient.
Szilvia Déri, János Borbás, Teodóra Hartai, Lidia Hategan, Beáta Csányi, Alain J Labro

Cardiovasc Res· July 2021

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iPSC-Cardiomyocyte Models of Brugada Syndrome-Achievements, Challenges and Future Perspectives.
Aleksandra Nijak, Johan Saenen, Alain J Labro, Dorien Schepers, Bart L Loeys

Int J Mol Sci· March 2021

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Reply to Pisupati et al.: Evaluating single subunit counting data to find the correct stoichiometry.
Lena Möller, Glenn Regnier, Alain J Labro, Dirk J Snyders, Rikard Blunck

Proc Natl Acad Sci U S A· November 2020

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Compound Heterozygous Mutations in Severe Sodium Channelopathy With Brugada Syndrome: A Case Report.
Aleksandra Nijak, Alain J Labro, Hans De Wilde, Wendy Dewals, Steve Peigneur

Front Cardiovasc Med· July 2020

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The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels.
Laura Coonen, Evy Mayeur, Nicolas De Neuter, Dirk J Snyders, Luis G Cuello, Alain J Labro

Biophys J· May 2020

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Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K and Na Channels.
Kenny M Van Theemsche, Dieter V Van de Sande, Dirk J Snyders, Alain J Labro

Front Pharmacol· May 2020

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Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations.
Lena Möller, Glenn Regnier, Alain J Labro, Rikard Blunck, Dirk J Snyders

Proc Natl Acad Sci U S A· April 2020

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Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model.
Dieter V Van de Sande, Ivan Kopljar, Ard Teisman, David J Gallacher, Dirk J Snyders, Alain J Labro

Front Pharmacol· December 2019

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Inverted allosteric coupling between activation and inactivation gates in K channels.
Alain J Labro, D Marien Cortes, Cholpon Tilegenova, Luis G Cuello

Proc Natl Acad Sci U S A· May 2018

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Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach.
Rym Hassiki, Alain J Labro, Zakaria Benlasfar, Cécile Vincke, Mahmoud Somia

Int J Biol Macromol· December 2016

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Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) pore.
Evelyn Martínez-Morales, Ivan Kopljar, Jon D Rainier, Jan Tytgat, Dirk J Snyders, Alain J Labro

Toxicon· September 2016

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Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels.
Ivan Kopljar, Alessandro Grottesi, Tessa de Block, Jon D Rainier, Jan Tytgat, Alain J Labro

Neuropharmacology· August 2016

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Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization.
Alain J Labro, Michael F Priest, Jérôme J Lacroix, Dirk J Snyders, Francisco Bezanilla

Nat Commun· December 2015

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