Publications by authors named "Alan D Cherrington"

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Ultrastable Insulin-Glucagon Fusion Protein Exploits an Endogenous Hepatic Switch to Mitigate Hypoglycemic Risk.
Nicolas Varas, Mark A Jarosinski, Yen-Shan Chen, Chun-Lun Ni, Rachel A Grabowski, Alan D Cherrington

ACS Pharmacol Transl Sci· September 2025

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Morning Elevation in Insulin Enhances Afternoon Postprandial Insulin Action and Glucose Effectiveness.
Hannah L Waterman, Marta S Smith, Ben Farmer, Kalisha Yankey, Tristan Howard, Alan D Cherrington

bioRxiv· July 2025

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Improved Afternoon Hepatic Glucose Disposal and Storage Requires Morning Engagement of Hepatic Insulin Receptors.
Hannah L Waterman, Mary Courtney Moore, Marta S Smith, Ben Farmer, Kalisha Yankey, Alan D Cherrington

Diabetes· March 2025

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A one-week reduced-carbohydrate diet to mitigate iatrogenic peripheral hyperinsulinemia does not improve insulin sensitivity or endothelial function in a randomized, crossover trial in patients with type 1 diabetes.
Justin M Gregory, T Jordan Smith, Sara H Duffus, David Brooks, M Naweed Akbar, Alan D Cherrington

Cardiovasc Diabetol· March 2025

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Hepatic Metabolic Memory Triggered by AM Exposure to Glucagon Alters Afternoon Glucose Metabolism.
Hannah L Waterman, Marta S Smith, Ben Farmer, Kalisha Yankey, Tristan Howard, Alan D Cherrington

bioRxiv· February 2025

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Duration of morning hyperinsulinemia determines hepatic glucose uptake and glycogen storage later in the day.
Hannah L Waterman, Mary Courtney Moore, Marta S Smith, Ben Farmer, Melanie Scott, Alan D Cherrington

Am J Physiol Endocrinol Metab· November 2024

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Morning Engagement of Hepatic Insulin Receptors Improves Afternoon Hepatic Glucose Disposal and Storage.
Hannah L Waterman, Mary Courtney Moore, Marta S Smith, Ben Farmer, Kalisha Yankey, Alan D Cherrington

bioRxiv· September 2024

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Duration of Morning Hyperinsulinemia Determines Hepatic Glucose Uptake and Glycogen Storage Later in the Day.
Hannah L Waterman, Mary Courtney Moore, Marta S Smith, Ben Farmer, Melanie Scott, Alan D Cherrington

bioRxiv· August 2024

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Ultra-stable insulin-glucagon fusion protein exploits an endogenous hepatic switch to mitigate hypoglycemic risk.
Nicolas Varas, Rachel Grabowski, Mark A Jarosinski, Ningwen Tai, Raimund I Herzog, Alan D Cherrington

bioRxiv· May 2024

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Integration of metabolic flux with hepatic glucagon signaling and gene expression profiles in the conscious dog.
Katie C Coate, Christopher J Ramnanan, Marta Smith, Jason J Winnick, Guillaume Kraft, Alan D Cherrington

Am J Physiol Endocrinol Metab· April 2024

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A high-fat and fructose diet in dogs mirrors insulin resistance and β-cell dysfunction characteristic of impaired glucose tolerance in humans.
Justin M Gregory, Guillaume Kraft, Chiara Dalla Man, James C Slaughter, Melanie F Scott, Alan D Cherrington

PLoS One· December 2023

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Integration of metabolic flux with hepatic glucagon signaling and gene expression profiles in the conscious dog.
Katie C Coate, Christopher J Ramnanan, Marta Smith, Jason J Winnick, Guillaume Kraft, Alan D Cherrington

bioRxiv· October 2023

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In Silico Investigation of the Clinical Translatability of Competitive Clearance Glucose-Responsive Insulins.
Jing Fan Yang, Sungyun Yang, Xun Gong, Naveed A Bakh, Ge Zhang, Alan D Cherrington

ACS Pharmacol Transl Sci· October 2023

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100 years of glucagon and 100 more.
Nicolai J Wewer Albrechtsen, Jens J Holst, Alan D Cherrington, Brian Finan, Lise Lotte Gluud

Diabetologia· August 2023

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Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog.
Guillaume Kraft, Katie C Coate, Marta Smith, Ben Farmer, Melanie Scott, Alan D Cherrington

Diabetes· February 2023

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A physiologic increase in brain glucagon action alters the hepatic gluconeogenic/glycogenolytic ratio but not glucagon's overall effect on glucose production.
Dale S Edgerton, Guillaume Kraft, Marta Smith, Ben Farmer, Phillip Williams, Alan D Cherrington

Am J Physiol Endocrinol Metab· February 2023

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A Gut-Centric Model of Metabolic Homeostasis.
Harith Rajagopalan, Juan Carlos Lopez-Talavera, David C Klonoff, Alan D Cherrington

J Diabetes Sci Technol· November 2022

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Efficacy and safety of Tregopil, a novel, ultra-rapid acting oral prandial insulin analog, as part of a basal-bolus regimen in type 2 diabetes: a randomized, active-controlled phase 2/3 study.
Harold E Lebovitz, Alexander Fleming, Alan D Cherrington, Shashank Joshi, Sandeep N Athalye

Expert Opin Pharmacother· November 2022

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COVID-19 Exacerbates Insulin Resistance During Diabetic Ketoacidosis in Pediatric Patients With Type 1 Diabetes.
Elizabeth S Keiner, James C Slaughter, Karishma A Datye, Alan D Cherrington, Daniel J Moore

Diabetes Care· October 2022

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Insulin Infusion Is Linked to Increased Expression in Muscle and Plasma C-type Natriuretic Peptide in Male Dogs.
Justin M Gregory, Guillaume Kraft, Ben Farmer, Marta S Smith, David C LaNeve, Alan D Cherrington

J Endocr Soc· July 2021

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C-peptide enhances glucagon secretion in response to hyperinsulinemia under euglycemic and hypoglycemic conditions.
Mary Courtney Moore, Shana O Warner, Yufei Dai, Nicole Sheanon, Marta Smith, Alan D Cherrington

JCI Insight· June 2021

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Importance of the route of insulin delivery to its control of glucose metabolism.
Dale S Edgerton, Mary C Moore, Justin M Gregory, Guillaume Kraft, Alan D Cherrington

Am J Physiol Endocrinol Metab· May 2021

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Voices: Insulin and beyond.
Jesse Roth, Frances M Ashcroft, Claes B Wollheim, Timothy J Kieffer, Alan D Cherrington

Cell Metab· April 2021

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Safety of surgical denervation of the common hepatic artery in insulin-resistant dogs.
Guillaume Kraft, Melanie Scott, Eric Allen, Dale S Edgerton, Ben Farmer, Alan D Cherrington

Physiol Rep· March 2021

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Author Correction: Molecular engineering of safe and efficacious oral basal insulin.
Frantisek Hubálek, Hanne H F Refsgaard, Sanne Gram-Nielsen, Peter Madsen, Erica Nishimura, Alan D Cherrington

Nat Commun· August 2020

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