Publications by authors named "Alan D D'Andrea"

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Repair Pathway Choices and Consequences at the Double-Strand Break.
Raphael Ceccaldi, Beatrice Rondinelli, Alan D D'Andrea

Trends Cell Biol· January 2016

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A phase Ib study of sapacitabine and olaparib in patients with BRCA1/2-mutated metastatic breast cancer.
Filipa Lynce, Noah Graham, Bose S Kochupurakkal, Huy Nguyen, Brittany Bychkovsky, Alan D D'Andrea

Clin Cancer Res· December 2025

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Defective Microhomology-Mediated End-joining in SMARCB1-Deficient Tumors.
Guangli Zhu, Shuhei Asada, Huy Nguyen, Yuna Hirohashi, Lifang Sun, Alan D D'Andrea

bioRxiv· November 2025

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Disruption of Microhomology-mediated End-joining in Ewing Sarcoma.
Shuhei Asada, Guangli Zhu, Jithma Prasad Abeykoon, Yutaro Tanaka, Huy Nguyen, Alan D D'Andrea

bioRxiv· September 2025

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CHAMP1 Complex Promotes Heterochromatin Assembly and Reduces Replication Stress.
Feng Li, Amira Elbakry, Felix Y Zhou, Tianpeng Zhang, Ramya Ravindranathan, Alan D D'Andrea

bioRxiv· August 2025

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USP1 inhibition: A journey from target discovery to clinical translation.
Carlos Torrado, Nicholas W Ashton, Alan D D'Andrea, Timothy A Yap

Pharmacol Ther· July 2025

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Lack of synergy between AR targeted therapies and PARP inhibitors in homologous recombination-proficient prostate cancer.
Nicole A Traphagen, Esmé Wheeler, Rong Li, Feng Lu, Buraq Ahmed, Alan D D'Andrea

bioRxiv· June 2025

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CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair.
Feng Li, Tianpeng Zhang, Aleem Syed, Amira Elbakry, Noella Holmer, Alan D D'Andrea

Nat Commun· February 2025

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PARG inhibitor sensitivity correlates with accumulation of single-stranded DNA gaps in preclinical models of ovarian cancer.
Ramya Ravindranathan, Ozge Somuncu, Alexandre André B A da Costa, Sirisha Mukkavalli, Benjamin P Lamarre, Alan D D'Andrea

Proc Natl Acad Sci U S A· November 2024

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Single-Stranded DNA Gap Accumulation Is a Functional Biomarker for USP1 Inhibitor Sensitivity.
Alexandre A da Costa, Ozge Somuncu, Ramya Ravindranathan, Sirisha Mukkavalli, David B Martignetti, Alan D D'Andrea

Cancer Res· October 2024

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CDK5-cyclin B1 regulates mitotic fidelity.
Xiao-Feng Zheng, Aniruddha Sarkar, Humphrey Lotana, Aleem Syed, Huy Nguyen, Alan D D'Andrea

Nature· September 2024

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Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression.
Miklos Diossy, Viktoria Tisza, Hua Li, Pranshu Sahgal, Jia Zhou, Alan D D'Andrea

NPJ Precis Oncol· September 2024

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DNA damage response in brain tumors: A Society for Neuro-Oncology consensus review on mechanisms and translational efforts in neuro-oncology.
Rifaquat Rahman, Diana D Shi, Zachary J Reitman, Petra Hamerlik, John F de Groot, Alan D D'Andrea

Neuro Oncol· August 2024

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The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway.
Naoya Harada, Shuhei Asada, Lige Jiang, Huy Nguyen, Lisa Moreau, Alan D D'Andrea

Mol Cell· July 2024

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Randomized Phase II Study of Gemcitabine With or Without ATR Inhibitor Berzosertib in Platinum-Resistant Ovarian Cancer: Final Overall Survival and Biomarker Analyses.
Panagiotis A Konstantinopoulos, Su-Chun Cheng, Elizabeth K Lee, Alexandre André B A da Costa, Doga Gulhan, Alan D D'Andrea

JCO Precis Oncol· April 2024

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A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma.
Brandon M Huffman, Hanrong Feng, Kalindi Parmar, Junning Wang, Kevin S Kapner, Alan D D'Andrea

Clin Cancer Res· December 2023

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STAG2 Regulates Homologous Recombination Repair and Sensitivity to ATM Inhibition.
Jie Zhou, Run-Cong Nie, Zhang-Ping He, Xiao-Xia Cai, Jie-Wei Chen, Alan D D'Andrea

Adv Sci (Weinh)· December 2023

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Retraction Note: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer.
Jeffrey Patterson-Fortin, Heta Jadhav, Constantia Pantelidou, Tin Phan, Carter Grochala, Alan D D'Andrea

Nat Commun· December 2023

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Transforming ovarian cancer care by targeting minimal residual disease.
Amir A Jazaeri, Rachel Grisham, Anne Knisely, Stefani Spranger, Dmitriy Zamarin, Alan D D'Andrea

Med· November 2023

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Targeting Polymerase Theta (POLθ) for Cancer Therapy.
Jeffrey Patterson-Fortin, Alan D D'Andrea

Cancer Treat Res· November 2023

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Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.
Aleem Syed, Frantisek Filandr, Jeffrey Patterson-Fortin, Albino Bacolla, Ramya Ravindranathan, Alan D D'Andrea

Nucleic Acids Res· October 2023

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Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs.
Michelle L Swift, Rui Zhou, Aleem Syed, Lisa A Moreau, Bartłomiej Tomasik, Alan D D'Andrea

Nat Struct Mol Biol· October 2023

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Fork restart: unloading FANCD2 to travel ahead.
Divya R Iyer, Alan D D'Andrea

Mol Cell· October 2023

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Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer.
Jeffrey Patterson-Fortin, Heta Jadhav, Constantia Pantelidou, Tin Phan, Carter Grochala, Alan D D'Andrea

Nat Commun· March 2023

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CCAR2 functions downstream of the Shieldin complex to promote double-strand break end-joining.
Divya Ramalingam Iyer, Naoya Harada, Connor Clairmont, Lige Jiang, David Martignetti, Alan D D'Andrea

Proc Natl Acad Sci U S A· December 2022

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TGFβ pathway is required for viable gestation of Fanconi anemia embryos.
Alfredo Rodríguez, Michael Epperly, Jessica Filiatrault, Martha Velázquez, Chunyu Yang, Alan D D'Andrea

PLoS Genet· November 2022

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