Publications by authors named "Alan Foster"

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Plasma Concentration as a Proxy for Perilymph Drug Levels: Preclinical and Clinical Dexamethasone Measures with a Long-Acting Formulation for Precise Delivery to the Round Window Membrane.
Benson T Jung, Jafri Kuthubutheen, Jeffrey D Sharon, Alan C Foster, Signe Erickson

Otol Neurotol· January 2025

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The efficacy of a TrkB monoclonal antibody agonist in preserving the auditory nerve in deafened guinea pigs.
Henk A Vink, Dyan Ramekers, Alan C Foster, Huib Versnel

Hear Res· November 2023

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Hearing loss: The final frontier of pharmacology.
Alan C Foster, Bonnie E Jacques, Fabrice Piu

Pharmacol Res Perspect· June 2022

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A neurotrophic approach to treating hearing loss: Translation from animal models to clinical proof-of-concept.
Alan C Foster, Stephanie Szobota, Fabrice Piu, Bonnie E Jacques, David R Moore

J Acoust Soc Am· June 2022

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Therapeutic Neuroprotection by an Engineered Neurotrophin that Selectively Activates Tropomyosin Receptor Kinase (Trk) Family Neurotrophin Receptors but Not the p75 Neurotrophin Receptor.
Fouad Brahimi, Alba Galan, Sairey Siegel, Stephanie Szobota, Marinko V Sarunic, Alan C Foster

Mol Pharmacol· November 2021

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BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss.
Stephanie Szobota, Pranav D Mathur, Sairey Siegel, KristenAnn Black, H Uri Saragovi, Alan C Foster

PLoS One· March 2020

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Inhibitors of the Neutral Amino Acid Transporters ASCT1 and ASCT2 Are Effective in In Vivo Models of Schizophrenia and Visual Dysfunction.
Yong-Xin Li, Jia-Ying Yang, Miguel Alcantara, Grigor Abelian, Ashutosh Kulkarni, Alan C Foster

J Pharmacol Exp Ther· November 2018

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Phenylglycine analogs are inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 and enhance NMDA receptor-mediated LTP in rat visual cortex slices.
Alan C Foster, Natalie Rangel-Diaz, Ursula Staubli, Jia-Ying Yang, Mahmud Penjwini

Neuropharmacology· November 2017

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D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures.
Alan C Foster, Jill Farnsworth, Genevieve E Lind, Yong-Xin Li, Jia-Ying Yang

PLoS One· July 2017

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Restoration of visual performance by d-serine in models of inner and outer retinal dysfunction assessed using sweep VEP measurements in the conscious rat and rabbit.
Ursula Staubli, Natalie Rangel-Diaz, Miguel Alcantara, Yong-Xin Li, Jia-Ying Yang, Alan C Foster

Vision Res· October 2016

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Activity of the enantiomers of erythro-3-hydroxyaspartate at glutamate transporters and NMDA receptors.
Alan C Foster, Yong-Xin Li, Stephen Runyan, Tim Dinh, Steven Venadas

J Neurochem· February 2016

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3-Aminoglutarate is a "silent" false transmitter for glutamate neurons.
Alan C Foster, June Chen, Stephen Runyan, Tim Dinh, Steven Venadas

Neuropharmacology· October 2015

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Effects of 3-aminoglutarate, a "silent" false transmitter for glutamate neurons, on synaptic transmission and epileptiform activity.
Zheng Wu, Alan C Foster, Ursula Staubli, Xia Wu, Chicheng Sun

Neuropharmacology· October 2015

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Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropathic pain.
Brian Dyck, Junko Tamiya, Florence Jovic, Rebecca R Pick, Margaret J Bradbury, Alan C Foster

J Med Chem· November 2008

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Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors.
Mingzhu Zhang, Florence Jovic, Troy Vickers, Brian Dyck, Junko Tamiya, Alan C Foster

Bioorg Med Chem Lett· July 2008

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Identification of 1S,2R-milnacipran analogs as potent norepinephrine and serotonin transporter inhibitors.
Junko Tamiya, Brian Dyck, Mingzhu Zhang, Kasey Phan, Beth A Fleck, Alan C Foster

Bioorg Med Chem Lett· June 2008

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Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors.
Troy Vickers, Brian Dyck, Junko Tamiya, Mingzhu Zhang, Florence Jovic, Alan C Foster

Bioorg Med Chem Lett· June 2008

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Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists.
Chen Chen, Fabio C Tucci, Wanlong Jiang, Joe A Tran, Beth A Fleck, Alan C Foster

Bioorg Med Chem· May 2008

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Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands.
Joe A Tran, Fabio C Tucci, Melissa Arellano, Wanlong Jiang, Caroline W Chen, Alan C Foster

Bioorg Med Chem Lett· March 2008

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Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors.
Chen Chen, Brian Dyck, Beth A Fleck, Alan C Foster, Jonathan Grey

Bioorg Med Chem Lett· February 2008

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Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor.
Chen Chen, Wanlong Jiang, Joe A Tran, Fabio C Tucci, Beth A Fleck, Alan C Foster

Bioorg Med Chem Lett· January 2008

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Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor.
Wanlong Jiang, Joe A Tran, Fabio C Tucci, Beth A Fleck, Sam R Hoare, Alan C Foster

Bioorg Med Chem Lett· December 2007

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Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor.
Joe A Tran, Wanlong Jiang, Fabio C Tucci, Beth A Fleck, Jenny Wen, Alan C Foster

J Med Chem· December 2007

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Discovery of 1-[2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl]-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active antagonist of the melanocortin-4 receptor for the potential treatment of cachexia.
Chen Chen, Wanlong Jiang, Fabio Tucci, Joe A Tran, Beth A Fleck, Alan C Foster

J Med Chem· November 2007

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Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor.
Wanlong Jiang, Fabio C Tucci, Joe A Tran, Beth A Fleck, Jenny Wen, Alan C Foster

Bioorg Med Chem Lett· October 2007

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