Publications by authors named "Alan G Wilson"

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Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes.
Nicole C Goodwin, Zhi-Ming Ding, Bryce A Harrison, Eric D Strobel, Angela L Harris, Alan G E Wilson

J Med Chem· January 2017

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4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase.
Qiang Han, Praveen K Pabba, Joseph Barbosa, Ross Mabon, Jason P Healy, Alan G E Wilson

Bioorg Med Chem Lett· February 2016

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Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma.
Bryce A Harrison, Zheng Y Almstead, Hugh Burgoon, Michael Gardyan, Nicole C Goodwin, Alan G E Wilson

ACS Med Chem Lett· January 2015

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A mathematical model of the London riots and their policing.
Toby P Davies, Hannah M Fry, Alan G Wilson, Steven R Bishop

Sci Rep· August 2013

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Evaluation of transporter-mediated hepatic uptake in a non-radioactive high-throughput assay: a study of kinetics, species difference and plasma protein effect.
Ling Li, Amr Nouraldeen, Alan G E Wilson

Xenobiotica· March 2013

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Development and application of a high-throughput formulation screening strategy for oral administration in drug discovery.
Suma Gopinathan, Amr Nouraldeen, Alan G E Wilson

Future Med Chem· September 2010

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The role of pharmacokinetic and pharmacokinetic/pharmacodynamic modeling in drug discovery and development.
Xiang-Qing Yu, Alan G E Wilson

Future Med Chem· June 2010

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Early toxicology signal generation in the mouse.
Jeffrey A Kramer, Emily O'Neill, Megan E Phillips, Debra Bruce, Traci Smith, Alan G E Wilson

Toxicol Pathol· April 2010

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A new paradigm for improving oral absorption of drugs in discovery: role of physicochemical properties, different excipients and the pharmaceutical scientist.
Alan G E Wilson, Amr Nouraldeen, Suma Gopinathan

Future Med Chem· January 2010

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5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase.
James E Tarver, Theodore C Jessop, Marianne Carlsen, David J Augeri, Qinghong Fu, Alan G E Wilson

Bioorg Med Chem Lett· December 2009

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Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors.
Theodore C Jessop, James E Tarver, Marianne Carlsen, Amy Xu, Jason P Healy, Alan G E Wilson

Bioorg Med Chem Lett· December 2009

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Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma.
Bryce A Harrison, N Andrew Whitlock, Michael V Voronkov, Zheng Y Almstead, Kun-jian Gu, Alan G E Wilson

J Med Chem· November 2009

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Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Nicole C Goodwin, Ross Mabon, Bryce A Harrison, Melanie K Shadoan, Zheng Y Almstead, Alan G E Wilson

J Med Chem· October 2009

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Application of emerging toxicity screens in drug discovery: challenges and implications.
Alan G E Wilson, Xuemei Liu, Jeffrey A Kramer

Future Med Chem· October 2009

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Development of a high-throughput human HepG(2) dual luciferase assay for detection of metabolically activated hepatotoxicants and genotoxicants.
Xuemei Liu, Jeffrey A Kramer, Yi Hu, James M Schmidt, Jianghong Jiang, Alan G E Wilson

Int J Toxicol· August 2009

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Development of a highthroughput yeast-based assay for detection of metabolically activated genotoxins.
Xuemei Liu, Jeffrey A Kramer, Jonathan C Swaffield, Yi Hu, Guixuan Chai, Alan G E Wilson

Mutat Res· May 2008

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Genotoxic potential of glyphosate formulations: mode-of-action investigations.
William F Heydens, Charles E Healy, Kathy J Hotz, Larry D Kier, Mark A Martens, Alan G E Wilson

J Agric Food Chem· February 2008

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Evaluation of a basic physiologically based pharmacokinetic model for simulating the first-time-in-animal study.
Massimiliano Germani, Patrizia Crivori, Maurizio Rocchetti, Philip S Burton, Alan G E Wilson

Eur J Pharm Sci· July 2007

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Evaluation of a physiologically-based pharmacokinetic approach for simulating the first-time-in-animal study.
Massimiliano Germani, Patrizia Crivori, Maurizio Rocchetti, Philip S Burton, Alan G E Wilson

Basic Clin Pharmacol Toxicol· March 2005

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Influence of molecular flexibility and polar surface area metrics on oral bioavailability in the rat.
Jing J Lu, Kimberly Crimin, Jay T Goodwin, Patrizia Crivori, Christian Orrenius, Alan G E Wilson

J Med Chem· November 2004

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A multiple in silico program approach for the prediction of mutagenicity from chemical structure.
Anita C White, Richard A Mueller, Robert H Gallavan, Sid Aaron, Alan G E Wilson

Mutat Res· August 2003

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Role of predictive metabolism and toxicity modeling in drug discovery--a summary of some recent advancements.
Alan G E Wilson, Anita C White, Richard A Mueller

Curr Opin Drug Discov Devel· January 2003

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