Publications by authors named "Alan Merk"

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Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization.
Lucy C Young, Ruby Goldstein de Salazar, Sae-Won Han, Zi Yi Stephanie Huang, Alan Merk

Proc Natl Acad Sci U S A· January 2023

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A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor.
Yongjian Huang, Jana Ognjenovic, Deepti Karandur, Kate Miller, Alan Merk

Elife· November 2021

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Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake.
Marc A Schureck, Joseph E Darling, Alan Merk, Jinfeng Shao, Geervani Daggupati

Elife· January 2021

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1.8 Å resolution structure of β-galactosidase with a 200 kV CRYO ARM electron microscope.
Alan Merk, Takuma Fukumura, Xing Zhu, Joseph E Darling, Reinhard Grisshammer

IUCrJ· July 2020

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Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases.
Yasushi Kondo, Jana Ognjenović, Saikat Banerjee, Deepti Karandur, Alan Merk

Science· October 2019

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Cryo-EM structures reveal coordinated domain motions that govern DNA cleavage by Cas9.
Xing Zhu, Ryan Clarke, Anupama K Puppala, Sagar Chittori, Alan Merk

Nat Struct Mol Biol· August 2019

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Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex.
Tai Wei Guo, Alberto Bartesaghi, Hui Yang, Veronica Falconieri, Prashant Rao, Alan Merk

Cell· October 2017

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Structural basis of kainate subtype glutamate receptor desensitization.
Joel R Meyerson, Sagar Chittori, Alan Merk, Prashant Rao, Tae Hee Han

Nature· September 2016

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Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle.
Gabriel A Frank, Suneet Shukla, Prashant Rao, Mario J Borgnia, Alberto Bartesaghi, Alan Merk

Mol Pharmacol· July 2016

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Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase.
Mario J Borgnia, Soojay Banerjee, Alan Merk, Doreen Matthies, Alberto Bartesaghi

Mol Pharmacol· June 2016

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Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery.
Alan Merk, Alberto Bartesaghi, Soojay Banerjee, Veronica Falconieri, Prashant Rao

Cell· June 2016

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2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition.
Soojay Banerjee, Alberto Bartesaghi, Alan Merk, Prashant Rao, Stacie L Bulfer

Science· February 2016

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Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating.
Doreen Matthies, Olivier Dalmas, Mario J Borgnia, Pawel K Dominik, Alan Merk

Cell· February 2016

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2.2 Å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor.
Alberto Bartesaghi, Alan Merk, Soojay Banerjee, Doreen Matthies, Xiongwu Wu

Science· June 2015

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Structure of β-galactosidase at 3.2-Å resolution obtained by cryo-electron microscopy.
Alberto Bartesaghi, Doreen Matthies, Soojay Banerjee, Alan Merk, Sriram Subramaniam

Proc Natl Acad Sci U S A· August 2014

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Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy.
Alberto Bartesaghi, Alan Merk, Mario J Borgnia, Jacqueline L S Milne, Sriram Subramaniam

Nat Struct Mol Biol· December 2013

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HIV-1 envelope glycoprotein structure.
Alan Merk, Sriram Subramaniam

Curr Opin Struct Biol· April 2013

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