Publications by authors named "Alan Rolfe"

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Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1.
Alan Rolfe, Shihua Yao, Toung-Vi Nguyen, Kiyoyuki Omoto, Federico Colombo

ACS Med Chem Lett· June 2020

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Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket.
Shihua Yao, Tuong-Vi Nguyen, Alan Rolfe, Anant A Agrawal, Jiyuan Ke

Cell Chem Biol· March 2020

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The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity.
Tuong-Vi Nguyen, Shihua Yao, Yahong Wang, Alan Rolfe, Anand Selvaraj

J Biol Chem· November 2019

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Synthesis of High-Load, Hybrid Silica-Immobilized Heterocyclic Benzyl Phosphate (Si-OHBP) and Triazolyl Phosphate (Si-OHTP) Alkylating Reagents.
Saqib Faisal, Pradip K Maity, Qin Zang, Alan Rolfe, Paul R Hanson

ACS Comb Sci· July 2016

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Silica-Supported Oligomeric Benzyl Phosphate (Si-OBP) and Triazole Phosphate (Si-OTP) Alkylating Reagents.
Pradip K Maity, Saqib Faisal, Alan Rolfe, Diana Stoianova, Paul R Hanson

J Org Chem· October 2015

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Exploring chemical diversity via a modular reaction pairing strategy.
Joanna K Loh, Sun Young Yoon, Thiwanka B Samarakoon, Alan Rolfe, Patrick Porubsky

Beilstein J Org Chem· October 2012

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Facile (triazolyl)methylation of MACOS-derived benzofused sultams utilizing ROMP-derived OTP reagents.
Saqib Faisal, Farman Ullah, Pradip K Maity, Alan Rolfe, Thiwanka B Samarakoon

ACS Comb Sci· April 2012

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Intramolecular monomer-on-monomer (MoM) Mitsunobu cyclization for the synthesis of benzofused thiadiazepine-dioxides.
Pradip K Maity, Quirin M Kainz, Saqib Faisal, Alan Rolfe, Thiwanka B Samarakoon

Chem Commun (Camb)· December 2011

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Synthesis of amino-benzothiaoxazepine-1,1-dioxides utilizing a microwave-assisted, S(N)Ar protocol.
Alan Rolfe, Farman Ullah, Thiwanka B Samarakoon, Ryan D Kurtz, Patrick Porubsky

ACS Comb Sci· November 2011

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A modular reaction pairing approach to the diversity-oriented synthesis of fused- and bridged-polycyclic sultams.
Thiwanka B Samarakoon, Joanna K Loh, Alan Rolfe, Lisa S Le, Sun Young Yoon

Org Lett· October 2011

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Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol.
Naeem Asad, Paul R Hanson, Toby R Long, Dinesh K Rayabarapu, Alan Rolfe

Chem Commun (Camb)· September 2011

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Triazole-containing isothiazolidine 1,1-dioxide library synthesis: one-pot, multi-component protocols for small molecular probe discovery.
Alan Rolfe, Thomas O Painter, Naeem Asad, Moon Young Hur, Kyu Ok Jeon

ACS Comb Sci· September 2011

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Accessing Stereochemically Rich Sultams via Microwave-Assisted, Continuous Flow Organic Synthesis (MACOS) Scale-out.
Michael G Organ, Paul R Hanson, Alan Rolfe, Thiwanka B Samarakoon, Farman Ullah

J Flow Chem· August 2011

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"Click"-capture, ring-opening metathesis polymerization (ROMP), release: facile triazolation utilizing ROMP-derived oligomeric phosphates.
Toby R Long, Saqib Faisal, Pradip K Maity, Alan Rolfe, Ryan Kurtz

Org Lett· April 2011

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Monomer-on-monomer (MoM) Mitsunobu reaction: facile purification utilizing surface-initiated sequestration.
Pradip K Maity, Alan Rolfe, Thiwanka B Samarakoon, Saqib Faisal, Ryan D Kurtz

Org Lett· January 2011

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High-load, hybrid Si-ROMP reagents.
Alan Rolfe, Joanna K Loh, Pradip K Maity, Paul R Hanson

Org Lett· January 2011

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S(N)Ar-based, facile synthesis of a library of benzothiaoxazepine-1,1'-dioxides.
Alan Rolfe, Thiwanka B Samarakoon, Sarra V Klimberg, Marek Brzozowski, Benjamin Neuenswander

J Comb Chem· November 2010

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One-pot, three-component, domino Heck-aza-Michael approach to libraries of functionalized 1,1-dioxido-1,2-benzisothiazoline-3-acetic acids.
Alan Rolfe, Kyle Young, Kelly Volp, Frank Schoenen, Benjamin Neuenswander

J Comb Chem· October 2010

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Scaling out by microwave-assisted, continuous flow organic synthesis (MACOS): multi-gram synthesis of bromo- and fluoro-benzofused sultams benzthiaoxazepine-1,1-dioxides.
Farman Ullah, Thiwanka Samarakoon, Alan Rolfe, Ryan D Kurtz, Paul R Hanson

Chemistry· September 2010

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Reagent based DOS: a "Click, Click, Cyclize" strategy to probe chemical space.
Alan Rolfe, Gerald H Lushington, Paul R Hanson

Org Biomol Chem· May 2010

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Formal [4+3] epoxide cascade reaction via a complementary ambiphilic pairing strategy.
Alan Rolfe, Thiwanka B Samarakoon, Paul R Hanson

Org Lett· March 2010

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Microwave-assisted sequential one-pot protocol to benzothiadiazin-3-one-1,1-dioxides via a copper-catalyzed N-arylation strategy.
Alan Rolfe, Paul R Hanson

Tetrahedron Lett· December 2009

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Metathesis Cascade Strategies (ROM-RCM-CM): A DOS approach to Skeletally Diverse Sultams.
Kyu Ok Jeon, Dinesh Rayabarapu, Alan Rolfe, Kelly Volp, Iman Omar

Tetrahedron· June 2009

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α-Haloarylsulfonamides: Multiple Cyclization Pathways to Skeletally Diverse Benzofused Sultams.
Dinesh Kumar Rayabarapu, Aihua Zhou, Kyu Ok Jeon, Thiwanka Samarakoon, Alan Rolfe

Tetrahedron· April 2009

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High-load, oligomeric dichlorotriazine: a versatile ROMP-derived reagent and scavenger.
Alan Rolfe, Donald A Probst, Kelly A Volp, Iman Omar, Daniel L Flynn

J Org Chem· November 2008

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