Publications by authors named "Alec A Desai"

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Maximizing activity and selectivity of antibody-mediated effector functions using antibody mixtures.
Tiexin Wang, Alec A Desai, Greg M Thurber, Peter M Tessier

MAbs· December 2025

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Directed evolution of drug-like Aβ conformation-specific antibodies.
Alec A Desai, Matthew D Smith, Jennifer M Zupancic, Emily K Makowski, Yulei Zhang

Front Immunol· October 2025

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Facile generation of drug-like conformational antibodies specific for amyloid fibrils.
Alec A Desai, Jennifer M Zupancic, Hanna Trzeciakiewicz, Julia E Gerson, Kelly N DuBois

Nat Chem Biol· June 2025

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Development of a pan-tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates.
Nikki McArthur, Bokyung Kang, Felix G Rivera Moctezuma, Akber T Shaikh, Kathryn Loeffler, Alec A Desai

Biotechnol Prog· October 2024

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Human antibody polyreactivity is governed primarily by the heavy-chain complementarity-determining regions.
Hsin-Ting Chen, Yulei Zhang, Jie Huang, Manali Sawant, Matthew D Smith, Alec A Desai

Cell Rep· October 2024

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Native ion mobility-mass spectrometry reveals the binding mechanisms of anti-amyloid therapeutic antibodies.
Yilin Han, Alec A Desai, Jennifer M Zupancic, Matthew D Smith, Peter M Tessier

Protein Sci· June 2024

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Facile generation of biepitopic antibodies with intrinsic agonism for activating tumor necrosis factor receptors.
Harkamal S Jhajj, John S Schardt, Namir Khalasawi, Emily L Yao, Timon S Lwo, Alec A Desai

Cell Chem Biol· May 2024

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Auto-tuning of Antibody-Drug Conjugate Delivery for Effective Immunotherapy using High-Avidity, Low-Affinity Antibodies.
Anna Kopp, Shujun Dong, Hyeyoung Kwon, Tiexin Wang, Alec A Desai

bioRxiv· April 2024

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Facile generation of biepitopic antibodies with intrinsic agonism for activating receptors in the tumor necrosis factor superfamily.
Harkamal S Jhajj, John S Schardt, Namir Khalasawi, Emily L Yao, Timon S Lwo, Alec A Desai

bioRxiv· December 2023

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Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrils.
Alec A Desai, Jennifer M Zupancic, Hanna Trzeciakiewicz, Julia E Gerson, Kelly N DuBois

bioRxiv· July 2023

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Reduction of therapeutic antibody self-association using yeast-display selections and machine learning.
Emily K Makowski, Hongwei Chen, Matthew Lambert, Eric M Bennett, Nicole S Eschmann, Alec A Desai

MAbs· November 2022

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Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space.
Emily K Makowski, Patrick C Kinnunen, Jie Huang, Lina Wu, Matthew D Smith, Alec A Desai

Nat Commun· July 2022

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Isolating Anti-amyloid Antibodies from Yeast-Displayed Libraries.
Alec A Desai, Jennifer M Zupancic, Matthew D Smith, Peter M Tessier

Methods Mol Biol· May 2022

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Facile isolation of high-affinity nanobodies from synthetic libraries using CDR-swapping mutagenesis.
Jennifer M Zupancic, Alec A Desai, Peter M Tessier

STAR Protoc· March 2022

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Rapid and Quantitative Evaluation of SARS-CoV-2 Neutralizing Antibodies and Nanobodies.
Weishu Wu, Xiaotian Tan, Jennifer Zupancic, John S Schardt, Alec A Desai

Anal Chem· March 2022

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Highly sensitive detection of antibody nonspecific interactions using flow cytometry.
Emily K Makowski, Lina Wu, Alec A Desai, Peter M Tessier

MAbs· January 2022

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A hybridoma-derived monoclonal antibody with high homology to the aberrant myeloma light chain.
Ghasidit Pornnoppadol, Boya Zhang, Alec A Desai, Anthony Berardi, Henriette A Remmer

PLoS One· November 2021

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Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening.
John S Schardt, Ghasidit Pornnoppadol, Alec A Desai, Kyung Soo Park, Jennifer M Zupancic

Sci Rep· October 2021

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Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis.
Jennifer M Zupancic, Alec A Desai, John S Schardt, Ghasidit Pornnoppadol, Emily K Makowski

Cell Chem Biol· September 2021

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Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity.
Alec A Desai, Matthew D Smith, Yulei Zhang, Emily K Makowski, Julia E Gerson

J Biol Chem· August 2021

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Engineered Multivalent Nanobodies Potently and Broadly Neutralize SARS-CoV-2 Variants.
Jennifer M Zupancic, John S Schardt, Alec A Desai, Emily K Makowski, Matthew D Smith

Adv Ther (Weinh)· August 2021

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Directed evolution of conformation-specific antibodies for sensitive detection of polypeptide aggregates in therapeutic drug formulations.
Wenjia Lou, Samuel D Stimple, Alec A Desai, Emily K Makowski, Sibel Kalyoncu

Biotechnol Bioeng· February 2021

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Physicochemical Rules for Identifying Monoclonal Antibodies with Drug-like Specificity.
Yulei Zhang, Lina Wu, Priyanka Gupta, Alec A Desai, Matthew D Smith

Mol Pharm· July 2020

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Sensitive detection of glucagon aggregation using amyloid fibril-specific antibodies.
Samuel D Stimple, Sibel Kalyoncu, Alec A Desai, Jesper E Mogensen, Lotte T Spang

Biotechnol Bioeng· August 2019

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Nature-inspired design and evolution of anti-amyloid antibodies.
Mark C Julian, Lilia A Rabia, Alec A Desai, Ammar Arsiwala, Julia E Gerson

J Biol Chem· May 2019

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