Publications by authors named "Alec Salt"

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Dexamethasone Dosing of Human Perilymph Compared for Common Delivery Protocols using Inner Ear Simulations.
Alec N Salt, Jeremy G Turner

Audiol Neurootol· December 2025

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Plasma Concentration as a Proxy for Perilymph Drug Levels: Preclinical and Clinical Dexamethasone Measures with a Long-Acting Formulation for Precise Delivery to the Round Window Membrane.
Benson T Jung, Jafri Kuthubutheen, Jeffrey D Sharon, Alan C Foster, Signe Erickson, Alec Salt

Otol Neurotol· January 2025

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Drug selection for inner ear therapy.
Alec N Salt, Jeremy G Turner

Front Pharmacol· October 2024

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A Guinea Pig Model Suggests That Objective Assessment of Acoustic Hearing Preservation in Human Ears With Cochlear Implants Is Confounded by Shifts in the Spatial Origin of Acoustically Evoked Potential Measurements Along the Cochlear Length.
Choongheon Lee, Jared J Hartsock, Alec N Salt, Jeffery T Lichtenhan

Ear Hear· April 2024

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Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs.
Adele Moatti, Shannon Connard, Novietta De Britto, William A Dunn, Srishti Rastogi, Alec Salt

Front Pharmacol· January 2024

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CACHD1-deficient mice exhibit hearing and balance deficits associated with a disruption of calcium homeostasis in the inner ear.
Cong Tian, Kenneth R Johnson, Jaclynn M Lett, Robert Voss, Alec N Salt

Hear Res· September 2021

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Improved Speech Intelligibility in Subjects With Stable Sensorineural Hearing Loss Following Intratympanic Dosing of FX-322 in a Phase 1b Study.
Will J McLean, Ashley S Hinton, Jenna T J Herby, Alec N Salt, Jared J Hartsock

Otol Neurotol· August 2021

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Reducing Auditory Nerve Excitability by Acute Antagonism of Ca-Permeable AMPA Receptors.
Amit Walia, Choongheon Lee, Jared Hartsock, Shawn S Goodman, Roland Dolle, Alec N Salt

Front Synaptic Neurosci· July 2021

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Steroid Nomenclature in Inner Ear Therapy.
Alec N Salt, Stefan K Plontke

Otol Neurotol· July 2020

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Dexamethasone and Dexamethasone Phosphate Entry into Perilymph Compared for Middle Ear Applications in Guinea Pigs.
Alec N Salt, Jared J Hartsock, Fabrice Piu, Jennifer Hou

Audiol Neurootol· October 2019

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Comparison of the Pharmacokinetic Properties of Triamcinolone and Dexamethasone for Local Therapy of the Inner Ear.
Alec Nicholas Salt, Jared James Hartsock, Jennifer Hou, Fabrice Piu

Front Cell Neurosci· July 2019

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Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications.
Alec N Salt, Stefan K Plontke

Hear Res· October 2018

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Local drug delivery to the inner ear: Principles, practice, and future challenges.
Stefan K Plontke, Alec N Salt

Hear Res· October 2018

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Hearing Changes After Intratympanic Steroids for Secondary (Salvage) Therapy of Sudden Hearing Loss: A Meta-Analysis Using Mathematical Simulations of Drug Delivery Protocols.
Arne Liebau, Olivia Pogorzelski, Alec N Salt, Stefan K Plontke

Otol Neurotol· August 2018

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Permeation Enhancers for Intratympanically-applied Drugs Studied Using Fluorescent Dexamethasone as a Marker.
Wei Li, Jared J Hartsock, Chunfu Dai, Alec N Salt

Otol Neurotol· June 2018

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Communication pathways to and from the inner ear and their contributions to drug delivery.
Alec N Salt, Keiko Hirose

Hear Res· May 2018

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Perilymph pharmacokinetics of marker applied through a cochlear implant in guinea pigs.
Alec Salt, Jared Hartsock, Ruth Gill, Daniel Smyth, Jonathon Kirk

PLoS One· October 2017

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Intracochlear Drug Injections through the Round Window Membrane: Measures to Improve Drug Retention.
Stefan K Plontke, Jared J Hartsock, Ruth M Gill, Alec N Salt

Audiol Neurootol· January 2017

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Hearing Changes After Intratympanically Applied Steroids for Primary Therapy of Sudden Hearing Loss: A Meta-analysis Using Mathematical Simulations of Drug Delivery Protocols.
Arne Liebau, Olivia Pogorzelski, Alec N Salt, Stefan K Plontke

Otol Neurotol· January 2017

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Drug Diffusion to the Apex of the Human Cochlea? A Comment on "Kang WS, Nguyen K, McKenna CE, Sewell WF, McKenna MJ, Jung DH. Intracochlear Drug Delivery Through the Oval Window in Fresh Cadaveric Human Temporal Bones".
Alec N Salt, Stefan K Plontke

Otol Neurotol· October 2016

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Systemic lipopolysaccharide compromises the blood-labyrinth barrier and increases entry of serum fluorescein into the perilymph.
Keiko Hirose, Jared J Hartsock, Shane Johnson, Peter Santi, Alec N Salt

J Assoc Res Otolaryngol· October 2014

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Gentamicin concentration gradients in scala tympani perilymph following systemic applications.
Hartmut Hahn, Alec N Salt, Ulrike Schumacher, Stefan K Plontke

Audiol Neurootol· August 2014

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Controlled release dexamethasone implants in the round window niche for salvage treatment of idiopathic sudden sensorineural hearing loss.
Stefan K Plontke, Alexander Glien, Torsten Rahne, Karsten Mäder, Alec N Salt

Otol Neurotol· August 2014

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Large endolymphatic potentials from low-frequency and infrasonic tones in the guinea pig.
Alec N Salt, Jeffery T Lichtenhan, Ruth M Gill, Jared J Hartsock

J Acoust Soc Am· March 2013

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Perilymph pharmacokinetics of markers and dexamethasone applied and sampled at the lateral semi-circular canal.
Alec N Salt, Jared J Hartsock, Ruth M Gill, Fabrice Piu, Stefan K Plontke

J Assoc Res Otolaryngol· December 2012

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