Publications by authors named "Alejandro Leroux"

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The role of S-adenosylhomocysteine hydrolase-like 1 in cancer.
Nicolás Budnik, Alejandro E Leroux, Mariana Cooke, Marcelo G Kazanietz, Carlos Vigliano

Biochim Biophys Acta Mol Cell Res· October 2024

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Molecular insights into the regulatory landscape of PKC-related kinase-2 (PRK2/PKN2) using targeted small compounds.
Lissy Z F Gross, Angelika F Winkel, Facundo Galceran, Jörg O Schulze, Wolfgang Fröhner, Alejandro E Leroux

J Biol Chem· August 2024

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The PB1 and the ZZ domain of the autophagy receptor p62/SQSTM1 regulate the interaction of p62/SQSTM1 with the autophagosome protein LC3B.
Lucia Alcober-Boquet, Tabea Zang, Larissa Pietsch, Evelyn Suess, Markus Hartmann, Alejandro E Leroux

Protein Sci· January 2024

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The choreography of protein kinase PDK1 and its diverse substrate dance partners.
Alejandro E Leroux, Ricardo M Biondi

Biochem J· October 2023

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Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein.
Mariana Sacerdoti, Lissy Z F Gross, Andrew M Riley, Karin Zehnder, Abhijeet Ghode, Alejandro E Leroux

Sci Signal· June 2023

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ACE2, the Receptor that Enables Infection by SARS-CoV-2: Biochemistry, Structure, Allostery and Evaluation of the Potential Development of ACE2 Modulators.
Lissy Z F Gross, Mariana Sacerdoti, Albrecht Piiper, Stefan Zeuzem, Alejandro E Leroux

ChemMedChem· September 2020

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Renaissance of Allostery to Disrupt Protein Kinase Interactions.
Alejandro E Leroux, Ricardo M Biondi

Trends Biochem Sci· January 2020

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Allosteric Regulation of Protein Kinases Downstream of PI3-Kinase Signalling.
Alejandro E Leroux, Lissy Z F Gross, Mariana Sacerdoti, Ricardo M Biondi

Adv Exp Med Biol· November 2019

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An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone.
Rachel B Currier, Kathrin Ulrich, Alejandro E Leroux, Natalie Dirdjaja, Matías Deambrosi

PLoS Pathog· September 2019

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AGC kinases, mechanisms of regulation ‎and innovative drug development.
Alejandro E Leroux, Jörg O Schulze, Ricardo M Biondi

Semin Cancer Biol· February 2018

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Molecular and functional characterization of two malic enzymes from Leishmania parasites.
Lucila Giordana, Máximo Hernán Sosa, Alejandro E Leroux, Elkin F Rodas Mendoza, Patricia Petray

Mol Biochem Parasitol· January 2018

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Thiol redox biology of trypanosomatids and potential targets for chemotherapy.
Alejandro E Leroux, R Luise Krauth-Siegel

Mol Biochem Parasitol· July 2017

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The silicon trypanosome: a test case of iterative model extension in systems biology.
Fiona Achcar, Abeer Fadda, Jurgen R Haanstra, Eduard J Kerkhoven, Dong-Hyun Kim, Alejandro E Leroux

Adv Microb Physiol· December 2014

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Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei.
Stefanie Zimmermann, Mouhssin Oufir, Alejandro Leroux, R Luise Krauth-Siegel, Katja Becker

Bioorg Med Chem· November 2013

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Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modeling.
Alejandro E Leroux, Jurgen R Haanstra, Barbara M Bakker, R Luise Krauth-Siegel

J Biol Chem· August 2013

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Low-molecular-mass antioxidants in parasites.
R Luise Krauth-Siegel, Alejandro E Leroux

Antioxid Redox Signal· August 2012

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Functional characterization of NADP-dependent isocitrate dehydrogenase isozymes from Trypanosoma cruzi.
Alejandro E Leroux, Dante A Maugeri, Juan J Cazzulo, Cristina Nowicki

Mol Biochem Parasitol· May 2011

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Comparative studies on the biochemical properties of the malic enzymes from Trypanosoma cruzi and Trypanosoma brucei.
Alejandro E Leroux, Dante A Maugeri, Fred R Opperdoes, Juan J Cazzulo, Cristina Nowicki

FEMS Microbiol Lett· January 2011

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Functional characterization and subcellular localization of the three malate dehydrogenase isozymes in Leishmania spp.
Alejandro Leroux, Ximena Fleming-Canepa, Alejandro Aranda, Dante Maugeri, Juan J Cazzulo

Mol Biochem Parasitol· September 2006

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