Publications by authors named "Alejandro Losada"

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Pharmacological reprogramming of plitidepsin as a SARS-CoV-2 inhibitor.
Jose Jimeno, Jose Felipe Varona, Jose A Lopez-Martin, Nuria Izquierdo-Useros, Elisa Molina Molina, Alejandro Losada

Mol Aspects Med· December 2025

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Patulin and Xestoquinol are inhibitors of DNA topoisomerase 1.
Emanuela Tumini, Ralf E Wellinger, Emilia Herrera-Moyano, Patricia Navarro-Cansino, María García-Rubio, Alejandro Losada

Proc Natl Acad Sci U S A· April 2025

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Targeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or mA protein synthesis routes.
Elisa Molina Molina, Joan Josep Bech-Serra, Eloi Franco-Trepat, Ignasi Jarne, Daniel Perez-Zsolt, Alejandro Losada

Nat Commun· February 2025

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Isolation and Total Synthesis of PM170453, a New Cyclic Depsipeptide Isolated from sp.
Rogelio Fernández, Marta Pérez, Alejandro Losada, Silvia Reboredo, Asier Gómez-San Juan

Mar Drugs· June 2024

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Plitidepsin as an Immunomodulator against Respiratory Viral Infections.
Alejandro Losada, Nuria Izquierdo-Useros, Pablo Aviles, Júlia Vergara-Alert, Irene Latino

J Immunol· April 2024

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Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis.
Martin Sachse, Raquel Tenorio, Isabel Fernández de Castro, Jordana Muñoz-Basagoiti, Daniel Perez-Zsolt, Alejandro Losada

Antiviral Res· April 2022

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Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.
Kris M White, Romel Rosales, Soner Yildiz, Thomas Kehrer, Lisa Miorin, Alejandro Losada

Science· February 2021

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Generation of endoplasmic reticulum stress and inhibition of autophagy by plitidepsin induces proteotoxic apoptosis in cancer cells.
Alejandro Losada, Juan José Berlanga, José Manuel Molina-Guijarro, Antonio Jiménez-Ruiz, Federico Gago

Biochem Pharmacol· February 2020

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Binding of eEF1A2 to the RNA-dependent protein kinase PKR modulates its activity and promotes tumour cell survival.
Alejandro Losada, María José Muñoz-Alonso, Marta Martínez-Díez, Federico Gago, Juan Manuel Domínguez

Br J Cancer· November 2018

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Dynamic cellular maps of molecular species: Application to drug-target interactions.
Carolina García, Alejandro Losada, Miguel A Sacristán, Juan Fernando Martínez-Leal, Carlos M Galmarini

Sci Rep· January 2018

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Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin.
Alejandro Losada, María José Muñoz-Alonso, Carolina García, Pedro A Sánchez-Murcia, Juan Fernando Martínez-Leal

Sci Rep· October 2016

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Antitumor actinopyranones produced by Streptomyces albus POR-04-15-053 isolated from a marine sediment.
Carmen Schleissner, Marta Pérez, Alejandro Losada, Pilar Rodríguez, Cristina Crespo

J Nat Prod· July 2011

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The mechanism of action of plitidepsin.
Maria J Muñoz-Alonso, Laura González-Santiago, Teresa Martínez, Alejandro Losada, Carlos M Galmarini

Curr Opin Investig Drugs· June 2009

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Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK.
Ana Cuadrado, Luis F Garcia-Fernandez, Laura Gonzalez, Yajaira Suarez, Alejandro Losada

J Biol Chem· January 2003

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Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta.
Luis F García-Fernández, Alejandro Losada, Victoria Alcaide, Alberto M Alvarez, Ana Cuadrado

Oncogene· October 2002

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