Publications by authors named "Alejandro Valbuena"

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Human Rhinovirus B14 with Non-functional Drug-binding Pockets Recovers Infectivity through Stereochemically Constrained Mutations that Restore Capsid Flexibility.
Juan Carlos Gil-Redondo, Luis Valiente, Valentín Riomoros-Barahona, Alejandro Valbuena, Mauricio G Mateu

J Mol Biol· September 2025

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Engineering mechanical strength and resistance to fatigue of a nanostructured protein material through genetic removal of electrostatic repulsions.
Judith Escrig, Juan Carlos Gil-Redondo, Alejandro Valbuena, Mauricio G Mateu

Nanoscale· September 2025

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A RNA Dodecahedral Cage Inside a Human Virus Plays a Dual Biological Role in Virion Assembly and Genome Release Control.
Luis Valiente, Valentín Riomoros-Barahona, Juan Carlos Gil-Redondo, José R Castón, Alejandro Valbuena

J Mol Biol· February 2025

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Engineering and Bio/Nanotechnological Applications of Virus Particles.
Mauricio G Mateu, Alejandro Valbuena

Subcell Biochem· December 2024

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Cryo-EM of human rhinovirus reveals capsid-RNA duplex interactions that provide insights into virus assembly and genome uncoating.
David Gil-Cantero, Carlos P Mata, Luis Valiente, Alicia Rodríguez-Huete, Alejandro Valbuena

Commun Biol· November 2024

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Structural Basis for Alternative Self-Assembly Pathways Leading to Different Human Immunodeficiency Virus Capsid-Like Nanoparticles.
Judith Escrig, Íñigo Marcos-Alcalde, Santos Domínguez-Zotes, David Abia, Paulino Gómez-Puertas, Alejandro Valbuena

ACS Nano· October 2024

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Single-Molecule Analysis of Genome Uncoating from Individual Human Rhinovirus Particles, and Modulation by Antiviral Drugs.
Alejandro Valbuena, Klara Strobl, Juan Carlos Gil-Redondo, Luis Valiente, Pedro J de Pablo

Small· February 2024

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Equilibrium Dynamics of a Biomolecular Complex Analyzed at Single-amino Acid Resolution by Cryo-electron Microscopy.
Daniel Luque, Alvaro Ortega-Esteban, Alejandro Valbuena, Jose Luis Vilas, Alicia Rodríguez-Huete

J Mol Biol· April 2023

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Electrostatic Screening, Acidic pH and Macromolecular Crowding Increase the Self-Assembly Efficiency of the Minute Virus of Mice Capsid In Vitro.
Miguel Angel Fuertes, Diego López Mateos, Luis Valiente, Alicia Rodríguez Huete, Alejandro Valbuena

Viruses· April 2023

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Metamorphism in TDP-43 prion-like domain determines chaperone recognition.
Jaime Carrasco, Rosa Antón, Alejandro Valbuena, David Pantoja-Uceda, Mayur Mukhi

Nat Commun· January 2023

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Molecular Determinants of Human Rhinovirus Infection, Assembly, and Conformational Stability at Capsid Protein Interfaces.
Luis Valiente, Silvia López-Argüello, Alicia Rodríguez-Huete, Alejandro Valbuena, Mauricio G Mateu

J Virol· December 2022

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A Genetically Engineered, Chain Mail-Like Nanostructured Protein Material with Increased Fatigue Resistance and Enhanced Self-Healing.
Santos Domínguez-Zotes, Miguel Angel Fuertes, Alicia Rodríguez-Huete, Alejandro Valbuena, Mauricio G Mateu

Small· March 2022

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Antiviral compounds modulate elasticity, strength and material fatigue of a virus capsid framework.
Santos Domínguez-Zotes, Alejandro Valbuena, Mauricio G Mateu

Biophys J· March 2022

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Visualization of Single Molecules Building a Viral Capsid Protein Lattice through Stochastic Pathways.
Alejandro Valbuena, Sourav Maity, Mauricio G Mateu, Wouter H Roos

ACS Nano· July 2020

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Nanomechanics of tip-link cadherins.
Javier Oroz, Albert Galera-Prat, Rubén Hervás, Alejandro Valbuena, Débora Fernández-Bravo

Sci Rep· September 2019

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Thermostability of the Foot-and-Mouth Disease Virus Capsid Is Modulated by Lethal and Viability-Restoring Compensatory Amino Acid Substitutions.
Silvia López-Argüello, Verónica Rincón, Alicia Rodríguez-Huete, Encarnación Martínez-Salas, Graham J Belsham, Alejandro Valbuena

J Virol· May 2019

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Structural determinants of mechanical resistance against breakage of a virus-based protein nanoparticle at a resolution of single amino acids.
María Medrano, Alejandro Valbuena, Alicia Rodríguez-Huete, Mauricio G Mateu

Nanoscale· May 2019

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Mechanical stiffening of human rhinovirus by cavity-filling antiviral drugs.
Alejandro Valbuena, Alicia Rodríguez-Huete, Mauricio G Mateu

Nanoscale· January 2018

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Corrigendum: Conformational rearrangements in the transmembrane domain of CNGA1 channels revealed by single-molecule force spectroscopy.
Sourav Maity, Monica Mazzolini, Manuel Arcangeletti, Alejandro Valbuena, Paolo Fabris

Nat Commun· September 2017

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Structural basis for biologically relevant mechanical stiffening of a virus capsid by cavity-creating or spacefilling mutations.
Pablo Guerra, Alejandro Valbuena, Jordi Querol-Audí, Cristina Silva, Milagros Castellanos

Sci Rep· June 2017

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Structural Analysis of a Temperature-Induced Transition in a Viral Capsid Probed by HDX-MS.
Michiel van de Waterbeemd, Aida Llauró, Joost Snijder, Alejandro Valbuena, Alicia Rodríguez-Huete

Biophys J· March 2017

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Amino Acid Side Chains Buried along Intersubunit Interfaces in a Viral Capsid Preserve Low Mechanical Stiffness Associated with Virus Infectivity.
Pablo José P Carrillo, María Medrano, Alejandro Valbuena, Alicia Rodríguez-Huete, Milagros Castellanos

ACS Nano· February 2017

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Kinetics of Surface-Driven Self-Assembly and Fatigue-Induced Disassembly of a Virus-Based Nanocoating.
Alejandro Valbuena, Mauricio G Mateu

Biophys J· February 2017

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Imaging and Quantitation of a Succession of Transient Intermediates Reveal the Reversible Self-Assembly Pathway of a Simple Icosahedral Virus Capsid.
María Medrano, Miguel Ángel Fuertes, Alejandro Valbuena, Pablo J P Carrillo, Alicia Rodríguez-Huete

J Am Chem Soc· November 2016

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Quantification and modification of the equilibrium dynamics and mechanics of a viral capsid lattice self-assembled as a protein nanocoating.
Alejandro Valbuena, Mauricio G Mateu

Nanoscale· September 2015

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