Publications by authors named "Ales Machara"

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Investigating NFE2L1 activators for targeted protein aggregate clearance: a follow-up study.
Zuzana Smahelova, Lucie Svobodova, Jindrich Sedlacek, Michael Adamek, Marketa Pimkova Polidarova, Ales Machara

RSC Med Chem· December 2025

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Targeting NFE2L1 signalling with small molecules to protect against Ferroptosis.
Lucie Svobodová, Jindřich Sedláček, Zuzana Šmahelová, Pavel Majer, Aleš Machara

Bioorg Med Chem Lett· October 2025

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3'-Dehydroxypurpurogallin-4-Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure-Activity Relationship Analysis, and Structural Characterization of Protein Complex.
Michal Kráľ, Tomáš Kotačka, Róbert Reiberger, Gabriela Panýrková, Kateřina Radilová, Aleš Machara

ChemMedChem· August 2025

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Identification of the trail-following pheromone receptor in termites.
Souleymane Diallo, Kateřina Kašparová, Josef Šulc, Jibin Johny, Jan Křivánek, Aleš Machara

Elife· August 2025

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Beyond natural flavonoids: exploring bioisosterism in design and synthesis of influenza endonuclease inhibitors.
Róbert Reiberger, Michal Kráľ, Kateřina Radilová, Tomáš Kotačka, Martin Dračínský, Aleš Machara

RSC Med Chem· July 2025

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Design, synthesis, and activity evaluation of C-8 arylated luteolin derivatives as influenza endonuclease inhibitors.
Artem Tsalyy, Michal Kráľ, Róbert Reiberger, Pavel Majer, Jan Konvalinka, Aleš Machara

Bioorg Med Chem Lett· June 2025

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3'-Dehydroxypurpurogallin-4-Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure-Activity Relationship Analysis, and Structural Characterization of Protein Complex.
Michal Kráľ, Tomáš Kotačka, Róbert Reiberger, Gabriela Panýrková, Kateřina Radilová, Aleš Machara

ChemMedChem· February 2025

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The evaluation of DNA-linked inhibitor antibody and AlphaScreen assays for high-throughput screening of compounds targeting the cap-binding domain in influenza a polymerase.
Kateřina Čermáková, Jiří Gregor, Michal Kráľ, Elena Karlukova, Václav Navrátil, Aleš Machara

Eur J Pharm Sci· February 2025

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Small-molecule activators of NRF1 transcriptional activity prevent protein aggregation.
Jindrich Sedlacek, Zuzana Smahelova, Michael Adamek, Dominika Subova, Lucie Svobodova, Ales Machara

Biomed Pharmacother· February 2025

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DSSBU: A novel mass spectrometry-cleavable analogue of the BS cross-linker.
Banerjee Swati, Sýs Jakub, Machara Aleš, Junková Petra, Hubálek Martin

J Proteomics· January 2025

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Evolution of Linoleic Acid Biosynthesis Paved the Way for Ecological Success of Termites.
Stanislav Macháček, Michal Tupec, Natan Horáček, Martina Halmová, Amit Roy, Aleš Machara

Mol Biol Evol· April 2023

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Characterization of Triacylglycerol Estolide Isomers Using High-Resolution Tandem Mass Spectrometry with Nanoelectrospray Ionization.
Lukáš Cudlman, Aleš Machara, Vladimír Vrkoslav, Miroslav Polášek, Zuzana Bosáková

Biomolecules· March 2023

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Thermodynamic and structural characterization of an optimized peptide-based inhibitor of the influenza polymerase PA-PB1 subunit interaction.
Kateřina Radilová, Václav Zima, Michal Kráľ, Aleš Machara, Pavel Majer

Antiviral Res· December 2022

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Diketo-Ketoenol Tautomers in Curcuminoids: Synthesis, Separation of Tautomers, and Kinetic and Structural Studies.
Zuzana Osifová, Robert Reiberger, Ivana Císařová, Aleš Machara, Martin Dračínský

J Org Chem· August 2022

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Understanding desaturation/hydroxylation activity of castor stearoyl Δ-Desaturase through rational mutagenesis.
Michal Tupec, Martin Culka, Aleš Machara, Stanislav Macháček, Daniel Bím

Comput Struct Biotechnol J· March 2022

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Binding of de novo synthesized radiolabeled juvenile hormone (JH III) by JH receptors from the Cuban subterranean termite Prorhinotermes simplex and the German cockroach Blattella germanica.
Matej Milacek, Lenka Bittova, Sarka Tumova, Ondrej Luksan, Robert Hanus, Ales Machara

Insect Biochem Mol Biol· December 2021

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Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors.
Robert Reiberger, Kateřina Radilová, Michal Kráľ, Václav Zima, Pavel Majer, Aleš Machara

Int J Mol Sci· July 2021

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structural characterization of the interaction between the C-terminal domain of the influenza polymerase PA subunit and an optimized small peptide inhibitor.
Jakub Hejdánek, Kateřina Radilová, Petr Pachl, Jan Hodek, Aleš Machara

Antiviral Res· January 2021

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Putative ligand binding sites of two functionally characterized bark beetle odorant receptors.
Jothi K Yuvaraj, Rebecca E Roberts, Yonathan Sonntag, Xiao-Qing Hou, Ewald Grosse-Wilde, Aleš Machara

BMC Biol· January 2021

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Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors.
Václav Zima, Kateřina Radilová, Milan Kožíšek, Carlos Berenguer Albiñana, Elena Karlukova, Aleš Machara

Eur J Med Chem· December 2020

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Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1.
Václav Zima, Carlos Berenguer Albiñana, Kateřina Rojíková, Jana Pokorná, Petr Pachl, Aleš Machara

Bioorg Med Chem· July 2019

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DNA-linked inhibitor antibody assay (DIANA) as a new method for screening influenza neuraminidase inhibitors.
Milan Kožíšek, Václav Navrátil, Kateřina Rojíková, Jana Pokorná, Carlos Berenguer Albiñana, Aleš Machara

Biochem J· December 2018

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Identification and Enantiodivergent Synthesis of (5 Z,9 S)-Tetradec-5-en-9-olide, a Queen-Specific Volatile of the Termite Silvestritermes minutus.
Aleš Machara, Jan Křivánek, Klára Dolejšová, Jana Havlíčková, Lucie Bednárová

J Nat Prod· October 2018

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Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus.
Jana Pokorná, Petr Pachl, Elena Karlukova, Jakub Hejdánek, Pavlína Řezáčová, Aleš Machara

Viruses· June 2018

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Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly.
Milan Kožíšek, Ondřej Štěpánek, Kamil Parkan, Carlos Berenguer Albiñana, Marcela Pávová, Aleš Machara

Bioorg Med Chem Lett· August 2016

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