Publications by authors named "Alessandro Butte"

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Self-Driving Development of Perfusion Processes for Monoclonal Antibody Production.
Chethana Janardhana Gadiyar, Claudio Müller, Thomas Vuillemin, Jean-Marc Bielser, Jonathan Souquet

Biotechnol Bioeng· December 2025

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Novel calibration design improves knowledge transfer across products for the characterization of pharmaceutical bioprocesses.
Laura M Helleckes, Claus Wirnsperger, Jakub Polak, Gonzalo Guillén-Gosálbez, Alessandro Butté

Biotechnol J· July 2024

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An innovative hybrid modeling approach for simultaneous prediction of cell culture process dynamics and product quality.
Jakub Polak, Zhuangrong Huang, Michael Sokolov, Moritz von Stosch, Alessandro Butté

Biotechnol J· March 2024

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Knowledge transfer across cell lines using hybrid Gaussian process models with entity embedding vectors.
Clemens Hutter, Moritz von Stosch, Mariano N Cruz Bournazou, Alessandro Butté

Biotechnol Bioeng· November 2021

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Design of Biopharmaceutical Formulations Accelerated by Machine Learning.
Harini Narayanan, Fabian Dingfelder, Itzel Condado Morales, Bhargav Patel, Kristine Enemærke Heding

Mol Pharm· October 2021

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Hybrid Models for the simulation and prediction of chromatographic processes for protein capture.
Harini Narayanan, Tobias Seidler, Martin Francisco Luna, Michael Sokolov, Massimo Morbidelli

J Chromatogr A· August 2021

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Machine Learning for Biologics: Opportunities for Protein Engineering, Developability, and Formulation.
Harini Narayanan, Fabian Dingfelder, Alessandro Butté, Nikolai Lorenzen, Michael Sokolov

Trends Pharmacol Sci· March 2021

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Cell culture process metabolomics together with multivariate data analysis tools opens new routes for bioprocess development and glycosylation prediction.
Philipp Zürcher, Michael Sokolov, David Brühlmann, Raphael Ducommun, Matthieu Stettler

Biotechnol Prog· September 2020

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Hybrid-EKF: Hybrid model coupled with extended Kalman filter for real-time monitoring and control of mammalian cell culture.
Harini Narayanan, Lars Behle, Martin F Luna, Michael Sokolov, Gonzalo Guillén-Gosálbez

Biotechnol Bioeng· September 2020

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Model based strategies towards protein A resin lifetime optimization and supervision.
Fabian Feidl, Martin F Luna, Matevz Podobnik, Sebastian Vogg, James Angelo

J Chromatogr A· August 2020

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Process-wide control and automation of an integrated continuous manufacturing platform for antibodies.
Fabian Feidl, Sebastian Vogg, Moritz Wolf, Matevz Podobnik, Caterina Ruggeri

Biotechnol Bioeng· May 2020

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Bioprocessing in the Digital Age: The Role of Process Models.
Harini Narayanan, Martin F Luna, Moritz von Stosch, Mariano Nicolas Cruz Bournazou, Gianmarco Polotti

Biotechnol J· January 2020

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A new generation of predictive models: The added value of hybrid models for manufacturing processes of therapeutic proteins.
Harini Narayanan, Michael Sokolov, Massimo Morbidelli, Alessandro Butté

Biotechnol Bioeng· October 2019

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A new flow cell and chemometric protocol for implementing in-line Raman spectroscopy in chromatography.
Fabian Feidl, Simone Garbellini, Sebastian Vogg, Michael Sokolov, Jonathan Souquet

Biotechnol Prog· September 2019

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Decision Tree-PLS (DT-PLS) algorithm for the development of process: Specific local prediction models.
Harini Narayanan, Michael Sokolov, Alessandro Butté, Massimo Morbidelli

Biotechnol Prog· July 2019

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Sequential Multivariate Cell Culture Modeling at Multiple Scales Supports Systematic Shaping of a Monoclonal Antibody Toward a Quality Target.
Michael Sokolov, Massimo Morbidelli, Alessandro Butté, Jonathan Souquet, Hervé Broly

Biotechnol J· April 2018

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Enhanced process understanding and multivariate prediction of the relationship between cell culture process and monoclonal antibody quality.
Michael Sokolov, Jonathan Ritscher, Nicola MacKinnon, Jonathan Souquet, Hervé Broly

Biotechnol Prog· September 2017

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Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve biosimilar product quality.
David Brühlmann, Michael Sokolov, Alessandro Butté, Markus Sauer, Jürgen Hemberger

Biotechnol Bioeng· July 2017

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Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody.
Michael Sokolov, Jonathan Ritscher, Nicola MacKinnon, Jean-Marc Bielser, David Brühlmann

Biotechnol Prog· January 2017

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Fingerprint detection and process prediction by multivariate analysis of fed-batch monoclonal antibody cell culture data.
Michael Sokolov, Miroslav Soos, Benjamin Neunstoecklin, Massimo Morbidelli, Alessandro Butté

Biotechnol Prog· October 2016

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Model-based description of peptide retention on doped reversed-phase media.
Rushd Khalaf, Nicola Forrer, Gianluca Buffolino, Alessandro Butté, Massimo Morbidelli

J Chromatogr A· August 2015

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Doping reversed-phase media for improved peptide purification.
Rushd Khalaf, Nicola Forrer, Gianluca Buffolino, David Gétaz, Susanna Bernardi

J Chromatogr A· June 2015

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New biphasic solvent system based on cyclopentyl methyl ether for the purification of a non-polar synthetic peptide by pH-zone refining centrifugal partition chromatography.
Nassima Amarouche, Leslie Boudesocque, Nicolas Borie, Matthieu Giraud, Luciano Forni, Alessandro Butte

J Sep Sci· June 2014

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Two novel solvent system compositions for protected synthetic peptide purification by centrifugal partition chromatography.
Nassima Amarouche, Matthieu Giraud, Luciano Forni, Alessandro Butte, F Edwards

J Chromatogr A· April 2014

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Purification of a modified cyclosporine A by co-current centrifugal partition chromatography: process development and intensification.
Nassima Amarouche, Leslie Boudesocque, Charlotte Sayagh, Matthieu Giraud, John McGarrity, Alessandro Butte

J Chromatogr A· October 2013

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