Publications by authors named "Alex Avdeef"

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Highly increasing solubility of clofazimine, an extremely water-insoluble basic drug, in lipid-based SEDDS using digestion products of long-chain lipids.
Hari P Kandagatla, Mufaddal H Kathawala, Amber Syed, Tatjana Ž Verbić, Alex Avdeef

J Pharm Sci· June 2025

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Aqueous Solubility of Sodium and Chloride Salts of Glycine─"Uncommon" Common-Ion Effects of Self-Titrating Solids.
Alex Avdeef, Abu T M Serajuddin, Hari P Kandagatla

Mol Pharm· February 2025

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Often neglected steps in transforming drug solubility from single measurement in pure water to physiologically-appropriate solubility-pH.
Alex Avdeef

ADMET DMPK· February 2025

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Effects of Different Weak Small Organic Acids on Clofazimine Solubility in Aqueous Media.
Igor A Topalović, Olivera S Marković, Miloš P Pešić, Mufaddal H Kathawala, Martin Kuentz, Alex Avdeef

Pharmaceutics· December 2024

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Supersolubilization and Amorphization of a Weakly Acidic Drug, Flurbiprofen, by applying Acid-Base supersolubilization (ABS) principle.
Mohammed I Syed, Hari P Kandagatla, Alex Avdeef, Abu T M Serajuddin

Int J Pharm· September 2024

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A comparison of USP 2 and µDISS Profiler™ apparatus for studying dissolution phenomena of ibuprofen and its salts.
Laurin Zöller, Alex Avdeef, Eva Karlsson, Anders Borde, Sara Carlert

Eur J Pharm Sci· February 2024

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Mechanistically transparent models for predicting aqueous solubility of rigid, slightly flexible, and very flexible drugs (MW<2000) Accuracy near that of random forest regression.
Alex Avdeef

ADMET DMPK· August 2023

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Clofazimine p Determination by Potentiometry and Spectrophotometry: Reverse Cosolvent Dependence as an Indicator of the Presence of Dimers in Aqueous Solutions.
Tatjana Ž Verbić, Kin Y Tam, Dušan Ž Veljković, Abu T M Serajuddin, Alex Avdeef

Mol Pharm· June 2023

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Anomalous salting-out, self-association and p effects in the practically-insoluble bromothymol blue.
Alex Avdeef

ADMET DMPK· May 2023

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Thickness of the aqueous boundary layer in stirred microtitre plate permeability assays (PAMPA and Caco-2), based on the Levich equation.
Alex Avdeef

ADMET DMPK· December 2022

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Understanding the pH Dependence of Supersaturation State-A Case Study of Telmisartan.
Szabina Kádár, Dóra Csicsák, Petra Tőzsér, Attila Farkas, Tamás Pálla, Alex Avdeef

Pharmaceutics· August 2022

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Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pH Domains with a Gibbs Phase Rule "Soft" Constraints.
Olivera S Marković, Nirali G Patel, Abu T M Serajuddin, Alex Avdeef, Tatjana Ž Verbić

Mol Pharm· February 2022

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Predicting Solubility of Newly-Approved Drugs (2016-2020) with a Simple ABSOLV and GSE() Consensus Model Outperforming Random Forest Regression.
Alex Avdeef, Manfred Kansy

J Solution Chem· February 2022

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Is equilibrium slurry pH a good surrogate for solid surface pH during drug dissolution?
Taiga Uekusa, Alex Avdeef, Kiyohiko Sugano

Eur J Pharm Sci· January 2022

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Salt Solubility and Disproportionation - Uses and Limitations of Equations for pH and the In-silico Prediction of pH.
Alex Avdeef, Kiyohiko Sugano

J Pharm Sci· January 2022

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Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development.
Claudia Miranda, Alejandro Ruiz-Picazo, Paula Pomares, Isabel Gonzalez-Alvarez, Marival Bermejo, Alex Avdeef

Pharmaceutics· January 2022

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Disproportionation of Pharmaceutical Salts: pH and Phase-Solubility/pH Variance.
Alex Avdeef

Mol Pharm· July 2021

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Ionizable Drug Self-Associations and the Solubility Dependence on pH: Detection of Aggregates in Saturated Solutions Using Mass Spectrometry (ESI-Q-TOF-MS/MS).
Elisabet Fuguet, Xavier Subirats, Clara Ràfols, Elisabeth Bosch, Alex Avdeef

Mol Pharm· June 2021

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The Critical Role of Passive Permeability in Designing Successful Drugs.
Li Di, Per Artursson, Alex Avdeef, Leslie Z Benet, J Brian Houston

ChemMedChem· October 2020

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"Flexible-Acceptor" General Solubility Equation for beyond Rule of 5 Drugs.
Alex Avdeef, Manfred Kansy

Mol Pharm· October 2020

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Findings of the Second Challenge to Predict Aqueous Solubility.
Antonio Llinas, Ioana Oprisiu, Alex Avdeef

J Chem Inf Model· October 2020

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Do you know your r?
Alex Avdeef

ADMET DMPK· August 2020

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Potentiometric CheqSol and standardized shake-flask solubility methods are complimentary tools in physicochemical profiling.
Diego Lucero-Borja, Xavier Subirats, Rafael Barbas, Rafel Prohens, Alex Avdeef

Eur J Pharm Sci· May 2020

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Can small drugs predict the intrinsic aqueous solubility of 'beyond Rule of 5' big drugs?
Alex Avdeef, Manfred Kansy

ADMET DMPK· April 2020

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Prediction of aqueous intrinsic solubility of druglike molecules using Random Forest regression trained with Wiki-pS0 database.
Alex Avdeef

ADMET DMPK· March 2020

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