Publications by authors named "Alex Ayoub"

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The FBXW7-KMT2 axis in cancer-associated fibroblasts controls tumor growth via an epigenetic-paracrine mechanism.
Lu Yin, Jiagui Zhang, Zhipeng Zhu, Xiaojuan Peng, Huiyin Lan, Alex Ayoub

Proc Natl Acad Sci U S A· April 2025

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The Impact of Sugar Conformation on the Single-Stranded DNA Selectivity of APOBEC3A and APOBEC3B Enzymes.
Mackenzie K Wyllie, Clare K Morris, Nicholas H Moeller, Henry A M Schares, Ramkumar Moorthy, Alex M Ayoub

ACS Chem Biol· January 2025

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Illuminating protein space with a programmable generative model.
John B Ingraham, Max Baranov, Zak Costello, Karl W Barber, Wujie Wang, Alex M Ayoub

Nature· November 2023

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Alternative Mechanisms for DNA Engagement by BET Bromodomain-Containing Proteins.
Prakriti Kalra, Huda Zahid, Alex Ayoub, Yali Dou, William C K Pomerantz

Biochemistry· July 2022

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Regulation of MLL1 Methyltransferase Activity in Two Distinct Nucleosome Binding Modes.
Alex Ayoub, Sang Ho Park, Young-Tae Lee, Uhn-Soo Cho, Yali Dou

Biochemistry· January 2022

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Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin.
Young-Tae Lee, Alex Ayoub, Sang-Ho Park, Liang Sha, Jing Xu

Nat Commun· May 2021

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New contributions to the phylogeny of the ciliate class Heterotrichea (Protista, Ciliophora): analyses at family-genus level and new evolutionary hypotheses.
Yong Chi, Xiangrui Chen, Yuqing Li, Chundi Wang, Tengteng Zhang, Alex Ayoub

Sci China Life Sci· April 2021

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Insights on the regulation of the MLL/SET1 family histone methyltransferases.
Liang Sha, Alex Ayoub, Uhn-Soo Cho, Yali Dou

Biochim Biophys Acta Gene Regul Mech· July 2020

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Publisher Correction: Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Sang Ho Park, Alex Ayoub, Young-Tae Lee, Jing Xu, Hanseong Kim

Nat Commun· February 2020

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Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Sang Ho Park, Alex Ayoub, Young-Tae Lee, Jing Xu, Hanseong Kim

Nat Commun· December 2019

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Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2'-Deoxyzebularine Analogues.
Maksim V Kvach, Fareeda M Barzak, Stefan Harjes, Henry A M Schares, Geoffrey B Jameson, Alex M Ayoub

Biochemistry· February 2019

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Design, Synthesis, and Characterization of a Fluorescence Polarization Pan-BET Bromodomain Probe.
Carolyn N Paulson, Xianghong Guan, Alex M Ayoub, Alice Chan, Rezaul M Karim

ACS Med Chem Lett· December 2018

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Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor.
Anand Divakaran, Siva K Talluri, Alex M Ayoub, Neeraj K Mishra, Huarui Cui

J Med Chem· October 2018

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Correction to BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.
Alex M Ayoub, Laura M L Hawk, Ryan J Herzig, Jiewei Jiang, Andrea J Wisniewski

J Med Chem· July 2017

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BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.
Alex M Ayoub, Laura M L Hawk, Ryan J Herzig, Jiewei Jiang, Andrea J Wisniewski

J Med Chem· June 2017

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