Publications by authors named "Alex C Koon"

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Pre- and postsynaptic upregulation of FasII synergistically underlies neuropathological and behavioral phenotypes in a Drosophila model of myotonic dystrophy.
Alex Chun Koon, Ka Yee Winnie Yeung, Yitao Wu, Lok I Leong, John Tsun Po Cheung

Nat Commun· December 2025

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Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5.
Zhefan Stephen Chen, Shaohong Isaac Peng, Lok I Leong, Terence Gall-Duncan, Nathan Siu Jun Wong, Alex Chun Koon

Nat Commun· April 2025

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Exploring the Relationship Between Trust-Building Strategies and Public Engagement on Social Media During the COVID-19 Outbreak.
Cindy Sing Bik Ngai, Rita Gill Singh, Wenze Lu, Le Yao, Alex Chun Koon

Health Commun· October 2023

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Grappling With the COVID-19 Health Crisis: Content Analysis of Communication Strategies and Their Effects on Public Engagement on Social Media.
Cindy Sing Bik Ngai, Rita Gill Singh, Wenze Lu, Alex Chun Koon

J Med Internet Res· August 2020

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FipoQ/FBXO33, a Cullin-1-based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein.
Zhefan Stephen Chen, Azaria Kam Yan Wong, Tat Cheung Cheng, Alex Chun Koon, Ho Yin Edwin Chan

J Neurochem· June 2019

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A Peptidylic Inhibitor for Neutralizing (GGGGCC)-Associated Neurodegeneration in C9ALS-FTD.
Qian Zhang, Ying An, Zhefan Stephen Chen, Alex Chun Koon, Kwok-Fai Lau

Mol Ther Nucleic Acids· June 2019

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AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models.
Huiling Hong, Alex Chun Koon, Zhefan Stephen Chen, Yuming Wei, Ying An

J Biol Chem· February 2019

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A discourse analysis of the macro-structure, metadiscoursal and microdiscoursal features in the abstracts of research articles across multiple science disciplines.
Sing Bik Cindy Ngai, Rita Gill Singh, Alex Chun Koon

PLoS One· October 2018

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Planar cell polarity gene triggers apoptosis in neurodegenerative disease models.
Zhefan Stephen Chen, Li Li, Shaohong Peng, Francis M Chen, Qian Zhang, Alex Chun Koon

EMBO Rep· September 2018

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Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress.
Alex Chun Koon, Zhefan Stephen Chen, Shaohong Peng, Joyce Man See Fung, Xiaoman Zhang

J Neurosci· September 2018

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Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.
Wen Li, Ka Ming Vincent Tam, Wai Wa Ray Chan, Alex Chun Koon, Jacky Chi Ki Ngo

J Biol Chem· May 2018

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A peptidylic inhibitor for neutralizing expanded RNA-induced nucleolar stress in polyglutamine diseases.
Qian Zhang, Zhefan Stephen Chen, Ying An, Haizhen Liu, Yonghui Hou, Alex Chun Koon

RNA· April 2018

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MicroRNAs regulate the sesquiterpenoid hormonal pathway in and other arthropods.
Zhe Qu, William G Bendena, Wenyan Nong, Kenneth W Siggens, Fernando G Noriega, Alex C Koon

Proc Biol Sci· December 2017

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GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer's disease.
Wai Yin Vivien Chiu, Alex Chun Koon, Jacky Chi Ki Ngo, Ho Yin Edwin Chan, Kwok-Fai Lau

Oncotarget· November 2017

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Expanded polyalanine tracts function as nuclear export signals and promote protein mislocalization via eEF1A1 factor.
Li Li, Nelson Ka Lam Ng, Alex Chun Koon, Ho Yin Edwin Chan

J Biol Chem· April 2017

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As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases.
Alex C Koon, Ho Yin Edwin Chan

Front Cell Neurosci· March 2017

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Inhibitory control of synaptic and behavioral plasticity by octopaminergic signaling.
Alex C Koon, Vivian Budnik

J Neurosci· May 2012

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Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling.
Alex C Koon, James Ashley, Romina Barria, Shamik DasGupta, Ruth Brain

Nat Neurosci· February 2011

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Activity-dependent regulation of inhibitory synapse development by Npas4.
Yingxi Lin, Brenda L Bloodgood, Jessica L Hauser, Ariya D Lapan, Alex C Koon

Nature· October 2008

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An RNAi-based approach identifies molecules required for glutamatergic and GABAergic synapse development.
Suzanne Paradis, Dana B Harrar, Yingxi Lin, Alex C Koon, Jessica L Hauser

Neuron· January 2007

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