Publications by authors named "Alex Cayley"

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A
Assessing the utility of common arguments used in expert review of in silico predictions as part of ICH M7 assessments.
Alex N Cayley, Robert S Foster, Alessandro Brigo, Wolfgang Muster, Alyssa Musso

Regul Toxicol Pharmacol· October 2023

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Risk assessment in the 21st century: where are we heading?
Susy Brescia, Camilla Alexander-White, Hequn Li, Alex Cayley

Toxicol Res (Camb)· February 2023

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Development of a network of carcinogenicity adverse outcome pathways and its employment as an evidence framework for safety assessment.
Alex N Cayley, Robert S Foster, Emma Hill, Steven Kane, Grace Kocks

ALTEX· January 2023

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Employing an adverse outcome pathway framework for weight-of-evidence assessment with application to the ICH S1B guidance addendum.
Susanne A Stalford, Alex N Cayley, Antonio Anax F de Oliveira

Regul Toxicol Pharmacol· December 2021

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Beyond adverse outcome pathways: making toxicity predictions from event networks, SAR models, data and knowledge.
Thomas Ball, Christopher G Barber, Alex Cayley, Martyn L Chilton, Robert Foster

Toxicol Res (Camb)· January 2021

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Management of pharmaceutical ICH M7 (Q)SAR predictions - The impact of model updates.
Catrin Hasselgren, Joel Bercu, Alex Cayley, Kevin Cross, Susanne Glowienke

Regul Toxicol Pharmacol· December 2020

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The importance of expert review to clarify ambiguous situations for (Q)SAR predictions under ICH M7.
Robert S Foster, Adrian Fowkes, Alex Cayley, Andrew Thresher, Anne-Laure D Werner

Genes Environ· September 2020

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Extrapolation of in vitro structural alerts for mutagenicity to the in vivo endpoint.
Rachael E Tennant, Sébastien J Guesné, Steven Canipa, Alex Cayley, William C Drewe

Mutagenesis· March 2019

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Important considerations for the validation of QSAR models for in vitro mutagenicity.
Alex Cayley, Adrian Fowkes, Richard V Williams

Mutagenesis· March 2019

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Improvement of quantitative structure-activity relationship (QSAR) tools for predicting Ames mutagenicity: outcomes of the Ames/QSAR International Challenge Project.
Masamitsu Honma, Airi Kitazawa, Alex Cayley, Richard V Williams, Chris Barber

Mutagenesis· March 2019

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Utility of published DNA reactivity alerts.
Alun Myden, Sebastien J Guesne, Alex Cayley, Richard V Williams

Regul Toxicol Pharmacol· August 2017

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E
Evaluation of a statistics-based Ames mutagenicity QSAR model and interpretation of the results obtained.
Chris Barber, Alex Cayley, Thierry Hanser, Alex Harding, Crina Heghes

Regul Toxicol Pharmacol· April 2016

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Using in vitro structural alerts for chromosome damage to predict in vivo activity and direct future testing.
Steven Canipa, Alex Cayley, William C Drewe, Richard V Williams, Shuichi Hamada

Mutagenesis· January 2016

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