Publications by authors named "Alex D Hoffman"

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I
In Vitro-In Vivo Extrapolation of Hepatic Biotransformation Data for Fish. III. An In-depth Case Study with Pyrene.
John W Nichols, Patrick N Fitzsimmons, Alex D Hoffman, Kameron Wong

Environ Toxicol Chem· July 2023

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Addition of Phenylmethylsulfonyl Fluoride Increases the Working Lifetime of the Trout Liver S9 Substrate Depletion Assay, Resulting in Improved Detection of Low Intrinsic Clearance Rates.
John W Nichols, Alex D Hoffman, Joe A Swintek, Steven T J Droge, Patrick N Fitzsimmons

Environ Toxicol Chem· January 2021

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Dietary Bioaccumulation and Biotransformation of Hydrophobic Organic Sunscreen Agents in Rainbow Trout.
Leslie J Saunders, Alex D Hoffman, John W Nichols, Frank A P C Gobas

Environ Toxicol Chem· March 2020

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Biotransformation of Polycyclic Aromatic Hydrocarbons by Trout Liver S9 Fractions: Evaluation of Competitive Inhibition Using a Substrate Depletion Approach.
John W Nichols, Melanie A Ladd, Alex D Hoffman, Patrick N Fitzsimmons

Environ Toxicol Chem· December 2019

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Allometric scaling of hepatic biotransformation in rainbow trout.
Patrick N Fitzsimmons, Alex D Hoffman, Kellie A Fay, John W Nichols

Comp Biochem Physiol C Toxicol Pharmacol· December 2018

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Toxicokinetics of the neonicotinoid insecticide imidacloprid in rainbow trout (Oncorhynchus mykiss).
John A Frew, Jacob T Brown, Patrick N Fitzsimmons, Alex D Hoffman, Martin Sadilek

Comp Biochem Physiol C Toxicol Pharmacol· February 2018

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Comparison of trout hepatocytes and liver S9 fractions as in vitro models for predicting hepatic clearance in fish.
Kellie A Fay, Patrick N Fitzsimmons, Alex D Hoffman, John W Nichols

Environ Toxicol Chem· February 2017

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Toxicokinetics of perfluorooctane sulfonate in rainbow trout (Oncorhynchus mykiss).
Daniel M Consoer, Alex D Hoffman, Patrick N Fitzsimmons, Patricia A Kosian, John W Nichols

Environ Toxicol Chem· March 2016

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O
Observed and modeled effects of pH on bioconcentration of diphenhydramine, a weakly basic pharmaceutical, in fathead minnows.
John W Nichols, Bowen Du, Jason P Berninger, Kristin A Connors, C Kevin Chambliss, Alex D Hoffman

Environ Toxicol Chem· June 2015

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Toxicokinetics of perfluorooctanoate (PFOA) in rainbow trout (Oncorhynchus mykiss).
Daniel M Consoer, Alex D Hoffman, Patrick N Fitzsimmons, Patricia A Kosian, John W Nichols

Aquat Toxicol· November 2014

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I
Intra- and interlaboratory reliability of a cryopreserved trout hepatocyte assay for the prediction of chemical bioaccumulation potential.
Kellie A Fay, Robert T Mingoia, Ina Goeritz, Diane L Nabb, Alex D Hoffman

Environ Sci Technol· July 2014

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Optimizing the use of rainbow trout hepatocytes for bioaccumulation assessments with fish.
Kellie A Fay, Patrick N Fitzsimmons, Alex D Hoffman, John W Nichols

Xenobiotica· April 2014

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Hepatic clearance of 6 polycyclic aromatic hydrocarbons by isolated perfused trout livers: prediction from in vitro clearance by liver S9 fractions.
John W Nichols, Alex D Hoffman, Thomas L ter Laak, Patrick N Fitzsimmons

Toxicol Sci· December 2013

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C
Comparative pharmaceutical metabolism by rainbow trout (Oncorhynchus mykiss) liver S9 fractions.
Kristin A Connors, Bowen Du, Patrick N Fitzsimmons, Alex D Hoffman, C Kevin Chambliss

Environ Toxicol Chem· August 2013

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Quantification of phenol, phenyl glucuronide, and phenyl sulfate in blood of unanesthetized rainbow trout by online microdialysis sampling.
John W Nichols, Alex D Hoffman, Patrick N Fitzsimmons, Gregory J Lien

Toxicol Mech Methods· October 2012

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O
Optimization of an isolated perfused rainbow trout liver model: Clearance studies with 7-ethoxycoumarin.
John W Nichols, Alex D Hoffman, Patrick N Fitzsimmons

Aquat Toxicol· November 2009

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Kinetics and effects of dichloroacetic acid in rainbow trout.
Patrick N Fitzsimmons, Alex D Hoffman, Gregory J Lien, Dean E Hammermeister, John W Nichols

Aquat Toxicol· September 2009

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Use of online microdialysis sampling to determine the in vivo rate of phenol glucuronidation in rainbow trout.
John W Nichols, Alex D Hoffman, Patrick N Fitzsimmons, Gregory J Lien, Correne T Jenson

Drug Metab Dispos· July 2008

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Uptake and elimination of ionizable organic chemicals at fish gills: I. Model formulation, parameterization, and behavior.
Russell J Erickson, James M McKim, Gregory J Lien, Alex D Hoffman, Sharon L Batterman

Environ Toxicol Chem· June 2006

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Uptake and elimination of ionizable organic chemicals at fish gills: II. Observed and predicted effects of ph, alkalinity, and chemical properties.
Russell J Erickson, James M McKim, Gregory J Lien, Alex D Hoffman, Sharon L Batterman

Environ Toxicol Chem· June 2006

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