Publications by authors named "Alex D White"

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Drug-induced phospholipidosis as an artifact in antiviral drug repurposing.
Isabella S Glenn, Lu Paris, Alex D White, Virginia G Garda, Mauricio Montano

bioRxiv· November 2025

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Membrane Perturbations and Assay Interferences by Ivermectin Explain Its In Vitro SARS-CoV-2 Antiviral Activities and Lack of Translatability.
Richard T Eastman, Radda Rusinova, Karl F Herold, Xi-Ping Huang, Ty Voss, Alex D White

J Med Chem· October 2025

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Differential Role of Phosphorylation in Glucagon Family Receptor Signaling Revealed by Mass Spectrometry.
Ian M Lamb, Alex D White, Francis S Willard, Michael J Chalmers, Junpeng Xiao

J Proteome Res· July 2025

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Hypophagia and body weight loss by tirzepatide are accompanied by fewer GI adverse events compared to semaglutide in preclinical models.
Tito Borner, Allison M Pataro, Sarah A Doebley, Charles D Furst, Alex D White

Sci Adv· June 2025

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Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH).
Sesh A Sundararaman, Justin J Miller, Ellora C Daley, Kelsey A O'Brien, Paulina Kasak, Alex D White

Proc Natl Acad Sci U S A· March 2025

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Deciphering the role of glycosaminoglycans in GPCR signaling.
Sofya Savransky, Alex D White, Jean-Pierre Vilardaga

Cell Signal· June 2024

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Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 activity.
Richard T Eastman, Radda Rusinova, Karl F Herold, Xi-Ping Huang, Patricia Dranchak, Alex D White

bioRxiv· October 2023

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Molecular Mechanisms of PTH/PTHrP Class B GPCR Signaling and Pharmacological Implications.
Jean-Pierre Vilardaga, Lisa J Clark, Alex D White, Ieva Sutkeviciute, Ji Young Lee

Endocr Rev· May 2023

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Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its N-terminal fragment 1 to 36.
Karina A Peña, Alex D White, Sofya Savransky, Ignacio Portales Castillo, Frédéric G Jean-Alphonse

J Biol Chem· September 2022

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Precise druggability of the PTH type 1 receptor.
Ieva Sutkeviciute, Ji Young Lee, Alex D White, Christian Santa Maria, Karina A Peña

Nat Chem Biol· March 2022

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Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation.
Alex D White, Karina A Peña, Lisa J Clark, Christian Santa Maria, Shi Liu

Sci Signal· October 2021

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Allosteric interactions in the parathyroid hormone GPCR-arrestin complex formation.
Lisa J Clark, James Krieger, Alex D White, Vasyl Bondarenko, Saifei Lei

Nat Chem Biol· October 2020

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G-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR.
Alex D White, Frederic G Jean-Alphonse, Fei Fang, Karina A Peña, Shi Liu

Proc Natl Acad Sci U S A· March 2020

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PTH hypersecretion triggered by a GABA and Ca-sensing receptor heterocomplex in hyperparathyroidism.
Wenhan Chang, Chia-Ling Tu, Frederic G Jean-Alphonse, Amanda Herberger, Zhiqiang Cheng, Alex D White

Nat Metab· March 2020

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PTH/PTHrP Receptor Signaling, Allostery, and Structures.
Ieva Sutkeviciute, Lisa J Clark, Alex D White, Thomas J Gardella, Jean-Pierre Vilardaga

Trends Endocrinol Metab· November 2019

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Use of Backbone Modification To Enlarge the Spatiotemporal Diversity of Parathyroid Hormone Receptor-1 Signaling via Biased Agonism.
Shi Liu, Frederic G Jean-Alphonse, Alex D White, Denise Wootten, Patrick M Sexton

J Am Chem Soc· September 2019

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Structure and dynamics of the active human parathyroid hormone receptor-1.
Li-Hua Zhao, Shanshan Ma, Ieva Sutkeviciute, Dan-Dan Shen, X Edward Zhou, Alex D White

Science· April 2019

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Ca allostery in PTH-receptor signaling.
Alex D White, Fei Fang, Frédéric G Jean-Alphonse, Lisa J Clark, Hyun-Jung An

Proc Natl Acad Sci U S A· February 2019

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Luminescence-activated nucleotide cyclase regulates spatial and temporal cAMP synthesis.
Nyla Naim, Alex D White, Jeff M Reece, Mamta Wankhede, Xuefeng Zhang

J Biol Chem· January 2019

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