Publications by authors named "Alex DePaoli"

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Circulating Citrate Is Associated with Liver Fibrosis in Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis.
Waseem Amjad, Irina Shalaurova, Erwin Garcia, Eke G Gruppen, Robin P F Dullaart, Alex M DePaoli

Int J Mol Sci· August 2023

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Aldafermin in patients with non-alcoholic steatohepatitis (ALPINE 2/3): a randomised, double-blind, placebo-controlled, phase 2b trial.
Stephen A Harrison, Manal F Abdelmalek, Guy Neff, Nadege Gunn, Cynthia D Guy, Alex M DePaoli

Lancet Gastroenterol Hepatol· July 2022

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Glucagon-receptor-antagonism-mediated β-cell regeneration as an effective anti-diabetic therapy.
Yannan Xi, Benbo Song, Iris Ngan, Mark J Solloway, Mark Humphrey, Alex DePaoli

Cell Rep· May 2022

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Inhibition of Complement Factor 3 in Geographic Atrophy with NGM621: Phase 1 Dose-Escalation Study Results.
Charles C Wykoff, Vrinda Hershberger, David Eichenbaum, Erin Henry, Husam S Younis, Alex DePaoli

Am J Ophthalmol· March 2022

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Potent suppression of hydrophobic bile acids by aldafermin, an FGF19 analogue, across metabolic and cholestatic liver diseases.
Arun J Sanyal, Lei Ling, Ulrich Beuers, Alex M DePaoli, Hsiao D Lieu

JHEP Rep· June 2021

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Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis.
Stephen A Harrison, Guy Neff, Cynthia D Guy, Mustafa R Bashir, Angelo H Paredes, Alex M DePaoli

Gastroenterology· January 2021

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The Commensal Microbe Veillonella as a Marker for Response to an FGF19 Analog in NASH.
Rohit Loomba, Lei Ling, Duy M Dinh, Alex M DePaoli, Hsiao D Lieu

Hepatology· January 2021

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NGM282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients With Nonalcoholic Steatohepatitis.
Stephen A Harrison, Stephen J Rossi, Angelo H Paredes, James F Trotter, Mustafa R Bashir, Alex M DePaoli

Hepatology· April 2020

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FGF19 Analog as a Surgical Factor Mimetic That Contributes to Metabolic Effects Beyond Glucose Homeostasis.
Alex M DePaoli, Mei Zhou, Daniel D Kaplan, Steven C Hunt, Ted D Adams

Diabetes· June 2019

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Rosuvastatin improves the FGF19 analogue NGM282-associated lipid changes in patients with non-alcoholic steatohepatitis.
Mary E Rinella, James F Trotter, Manal F Abdelmalek, Angelo H Paredes, Margery A Connelly, Alex M DePaoli

J Hepatol· April 2019

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Effect of NGM282, an FGF19 analogue, in primary sclerosing cholangitis: A multicenter, randomized, double-blind, placebo-controlled phase II trial.
Gideon M Hirschfield, Olivier Chazouillères, Joost P Drenth, Douglas Thorburn, Stephen A Harrison, Alex M DePaoli

J Hepatol· March 2019

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Therapeutic FGF19 promotes HDL biogenesis and transhepatic cholesterol efflux to prevent atherosclerosis.
Mei Zhou, R Marc Learned, Stephen J Rossi, Hui Tian, Alex M DePaoli

J Lipid Res· March 2019

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NGM282 for Treatment of Patients With Primary Biliary Cholangitis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial.
Marlyn J Mayo, Alan J Wigg, Barbara A Leggett, Hays Arnold, Alexander J Thompson, Alex M DePaoli

Hepatol Commun· September 2018

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Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis.
Katharina Brandl, Phillipp Hartmann, Lily J Jih, Donald P Pizzo, Josepmaria Argemi, Alex M DePaoli

J Hepatol· August 2018

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Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice.
Phillipp Hartmann, Katrin Hochrath, Angela Horvath, Peng Chen, Caroline T Seebauer, Alex M DePaoli

Hepatology· June 2018

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NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.
Stephen A Harrison, Mary E Rinella, Manal F Abdelmalek, James F Trotter, Angelo H Paredes, Alex M DePaoli

Lancet· March 2018

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Engineered FGF19 eliminates bile acid toxicity and lipotoxicity leading to resolution of steatohepatitis and fibrosis in mice.
Mei Zhou, R Marc Learned, Stephen J Rossi, Alex M DePaoli, Hui Tian

Hepatol Commun· December 2017

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Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15.
Mei Zhou, Jian Luo, Michael Chen, Hong Yang, R Marc Learned, Alex M DePaoli

J Hepatol· June 2017

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Lymphoma in acquired generalized lipodystrophy.
Rebecca J Brown, Jean L Chan, Elaine S Jaffe, Elaine Cochran, Alex M DePaoli

Leuk Lymphoma· October 2016

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Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2-deficient mice.
Mei Zhou, R Marc Learned, Stephen J Rossi, Alex M DePaoli, Hui Tian

Hepatology· March 2016

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20 years of leptin: leptin in common obesity and associated disorders of metabolism.
Alex M DePaoli

J Endocrinol· October 2014

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Can a selective PPARγ modulator improve glycemic control in patients with type 2 diabetes with fewer side effects compared with pioglitazone?
Alex M DePaoli, Linda S Higgins, Robert R Henry, Christos Mantzoros, Fredrick L Dunn

Diabetes Care· July 2014

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A nontumorigenic variant of FGF19 treats cholestatic liver diseases.
Jian Luo, Brian Ko, Michael Elliott, Mei Zhou, Darrin A Lindhout, Alex M DePaoli

Sci Transl Med· July 2014

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Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19.
Mei Zhou, Xueyan Wang, Van Phung, Darrin A Lindhout, Kalyani Mondal, Alex M DePaoli

Cancer Res· June 2014

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Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet.
Greeshma K Shetty, Giuseppe Matarese, Faidon Magkos, Hyun-Seuk Moon, Xiaowen Liu, Alex M Depaoli

Eur J Endocrinol· August 2011

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