Publications by authors named "Alex E. Clark"

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Interferon-inducible guanylate-binding protein 5 inhibits replication of multiple viruses by binding to the oligosaccharyltransferase complex and inhibiting glycoprotein maturation.
Shaobo Wang, Wanyu Li, Jing Wen, Lingling Wang, Shashi Kant Tiwari, Alex E Clark

mBio· December 2025

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Correction: Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern.
Gonzalo Almanza, Alex E Clark, Valentina Kouznetsova, Eduardo Olmedillas, Andrea Castro

PLoS Pathog· November 2025

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Genome-Wide Interrogation of SARS-CoV-2 RNA-Protein Interactions Uncovers Hidden Regulatory Sites.
Joy S Xiang, Karen X Zhao, Laliv Tadri, Kurt Tamaru, Brian A Yee, Alex E Clark

bioRxiv· May 2025

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Antibody Levels From High-Throughput Variant-Specific SARS-CoV-2 Anti-Spike Immunoglobulin G and Angiotensin-Converting Enzyme 2 Neutralization Assays Correlate With COVID-19 Infection Risk in a Large Population.
Marni B Jacobs, Alex E Clark, Nicole H Goldhaber, Holly D Valentine, Andrea Rivera

J Infect Dis· April 2025

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SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx.
Cameron Martino, Benjamin P Kellman, Daniel R Sandoval, Thomas Mandel Clausen, Robert Cooper, Alex E Clark

mBio· April 2025

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Zika but not Dengue virus infection limits NF-κB activity in human monocyte-derived dendritic cells and suppresses their ability to activate T cells.
Ying-Ting Wang, Emilie Branche, Jialei Xie, Rachel E McMillan, Fernanda Ana-Sosa-Batiz, Alex E Clark

Nat Commun· March 2025

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A label-free optical biosensor-based point-of-care test for the rapid detection of Monkeypox virus.
Mete Aslan, Elif Seymour, Howard Brickner, Alex E Clark, Iris Celebi

Biosens Bioelectron· February 2025

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Ultrasensitive detection of intact SARS-CoV-2 particles in complex biofluids using microfluidic affinity capture.
Daniel C Rabe, Adarsh Choudhury, Dasol Lee, Evelyn G Luciani, Uyen K Ho, Alex E Clark

Sci Adv· January 2025

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Matrix-Insensitive Sensor Arrays via Peptide-Coated Nanoparticles: Rapid Saliva Screening for Pathogens in Oral and Respiratory Diseases.
Benjamin Lam, Lubna Amer, Elizabeth Thompson, Alex E Clark, Aaron F Garretson

ACS Appl Mater Interfaces· December 2024

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Oral pharmacokinetics and efficacy of oral phospholipid remdesivir nucleoside prodrugs against SARS-CoV-2 in mice.
Aaron F Carlin, James R Beadle, Jeremy Ardanuy, Alex E Clark, Victoria Rhodes

Antimicrob Agents Chemother· October 2024

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A Label-free Optical Biosensor-Based Point-of-Care Test for the Rapid Detection of Monkeypox Virus.
Mete Aslan, Elif Seymour, Howard Brickner, Alex E Clark, Iris Celebi

medRxiv· July 2024

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A therapy for suppressing canonical and noncanonical SARS-CoV-2 viral entry and an intrinsic intrapulmonary inflammatory response.
Sandra L Leibel, Rachael N McVicar, Rabi Murad, Elizabeth M Kwong, Alex E Clark

Proc Natl Acad Sci U S A· July 2024

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Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation.
Shaobo Wang, Wanyu Li, Lingling Wang, Shashi Kant Tiwari, William Bray, Alex E Clark

bioRxiv· May 2024

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Design and Development of an Antigen Test for SARS-CoV-2 Nucleocapsid Protein to Validate the Viral Quality Assurance Panels.
Partha Ray, Melissa Ledgerwood-Lee, Howard Brickner, Alex E Clark, Aaron Garretson

Viruses· April 2024

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Enhanced broad spectrum in vitro antiviral efficacy of 3-F-4-MeO-Bn, 3-CN, and 4-CN derivatives of lipid remdesivir nucleoside monophosphate prodrugs.
Rachel E McMillan, Michael K Lo, Xing-Quan Zhang, James R Beadle, Nadejda Valiaeva, Alex E Clark

Antiviral Res· November 2023

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Validating Tools to Detect and Inactivate Monkeypox Virus in Human Milk.
Alex E Clark, Annalee Furst, Kristija Sejane, Lisa Stellwagen, Marissa Proost

Breastfeed Med· October 2023

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1--Octadecyl-2--benzyl--glyceryl-3--GS-441524 (V2043). Evaluation of Oral V2043 in a Mouse Model of SARS-CoV-2 Infection and Synthesis and Antiviral Evaluation of Additional Phospholipid Esters with Enhanced Anti-SARS-CoV-2 Activity.
Aaron F Carlin, James R Beadle, Alex E Clark, Kendra L Gully, Fernando R Moreira

J Med Chem· April 2023

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Neutralizing Antibody Responses After Severe Acute Respiratory Syndrome Coronavirus 2 BA.2 and BA.2.12.1 Infection Do Not Neutralize BA.4 and BA.5 and Can Be Blunted by Nirmatrelvir/Ritonavir Treatment.
Aaron F Carlin, Alex E Clark, Aaron F Garretson, William Bray, Magali Porrachia

Open Forum Infect Dis· April 2023

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Protease-Responsive Potential-Tunable AIEgens for Cell Selective Imaging of TMPRSS2 and Accurate Inhibitor Screening.
Yong Cheng, Alex E Clark, Wonjun Yim, Raina M Borum, Yu-Ci Chang

Anal Chem· February 2023

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Identification of global inhibitors of cellular glycosylation.
Daniel Madriz Sørensen, Christian Büll, Thomas D Madsen, Erandi Lira-Navarrete, Thomas Mandel Clausen, Alex E Clark

Nat Commun· February 2023

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PCIF1-mediated deposition of 5'-cap ,2'--dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection.
Lingling Wang, Shaobo Wang, Lujing Wu, Wanyu Li, William Bray, Alex E Clark

Proc Natl Acad Sci U S A· January 2023

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The lung employs an intrinsic surfactant-mediated inflammatory response for viral defense.
Sandra L Leibel, Rachael N McVicar, Rabi Murad, Elizabeth M Kwong, Alex E Clark

bioRxiv· January 2023

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Discovery of New Zika Protease and Polymerase Inhibitors through the Open Science Collaboration Project OpenZika.
Melina Mottin, Bruna Katiele de Paula Sousa, Nathalya Cristina de Moraes Roso Mesquita, Ketllyn Irene Zagato de Oliveira, Gabriela Dias Noske, Alex E Clark

J Chem Inf Model· December 2022

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In Vitro Diagnostic Assay to Detect SARS-CoV-2-Neutralizing Antibody in Patient Sera Using Engineered ACE-2 Mini-Protein.
Bruna Andersen Pereira de Jesus, Anderson Albino Gomes, Alex E Clark, Tayse Andrade Rodrigues, Melissa Ledgerwood-Lee

Viruses· December 2022

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SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus.
Emilie Branche, Ying-Ting Wang, Karla M Viramontes, Joan M Valls Cuevas, Jialei Xie, Alex E Clark

Nat Commun· September 2022

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