Publications by authors named "Alex Gauthier"

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Cultivated autologous limbal epithelial cell (CALEC) transplantation for limbal tem cell deficiency: a phase I/II clinical trial of the first xenobiotic-free, serum-free, antibiotic-free manufacturing protocol developed in the US.
Ula V Jurkunas, Aaron R Kaufman, Jia Yin, Allison Ayala, Maureen Maguire, Alex Gauthier

Nat Commun· March 2025

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Modulation of ATM enhances DNA repair in G2/M phase of cell cycle and averts senescence in Fuchs endothelial corneal dystrophy.
Shazia Ashraf, Neha Deshpande, Queenie Cheung, Jeffrey Boakye Asabere, Raymond Jeff Wong, Alex G Gauthier

Commun Biol· November 2024

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A Standardized Botanical Composition Mitigated Acute Inflammatory Lung Injury and Reduced Mortality through Extracellular HMGB1 Reduction.
Mesfin Yimam, Teresa Horm, Alexandria O'Neal, Ping Jiao, Mei Hong, Alex Gauthier

Molecules· September 2023

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Cultivated autologous limbal epithelial cell (CALEC) transplantation: Development of manufacturing process and clinical evaluation of feasibility and safety.
Ula V Jurkunas, Jia Yin, Lynette K Johns, Sanming Li, Helene Negre, Alex Gauthier

Sci Adv· August 2023

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GAT107-mediated α7 nicotinic acetylcholine receptor signaling attenuates inflammatory lung injury and mortality in a mouse model of ventilator-associated pneumonia by alleviating macrophage mitochondrial oxidative stress via reducing MnSOD-S-glutathionylation.
Alex G Gauthier, Mosi Lin, Sidorela Zefi, Abhijit Kulkarni, Ganesh A Thakur

Redox Biol· April 2023

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Dual effects of supplemental oxygen on pulmonary infection, inflammatory lung injury, and neuromodulation in aging and COVID-19.
Mosi Lin, Maleka T Stewart, Sidorela Zefi, Kranthi Venkat Mateti, Alex Gauthier

Free Radic Biol Med· September 2022

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From nicotine to the cholinergic anti-inflammatory reflex - Can nicotine alleviate the dysregulated inflammation in COVID-19?
Alex G Gauthier, Mosi Lin, Jiaqi Wu, Thomas P Kennedy, Lee-Anne Daley

J Immunotoxicol· December 2021

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Correction to: 2‑O, 3‑O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1‑compromised macrophage function.
Mao Wang, Alex G Gauthier, Thomas P Kennedy, Haichao Wang, Uday Kiran Velagapudi

Mol Med· September 2021

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Correction to: GTS-21, an α7nAChR agonist, increases pulmonary bacterial clearance in mice by restoring hyperoxia-compromised macrophage function.
Ravikumar A Sitapara, Alex G Gauthier, Vivek S Patel, Mosi Lin, Michelle Zur

Mol Med· August 2021

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2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function.
Mao Wang, Alex G Gauthier, Thomas P Kennedy, Haichao Wang, Uday Kiran Velagapudi

Mol Med· July 2021

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Cell cycle re-entry and arrest in G2/M phase induces senescence and fibrosis in Fuchs Endothelial Corneal Dystrophy.
Tomas L White, Neha Deshpande, Varun Kumar, Alex G Gauthier, Ula V Jurkunas

Free Radic Biol Med· February 2021

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The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages.
Alex G Gauthier, Jiaqi Wu, Mosi Lin, Ravikumar Sitapara, Abhijit Kulkarni

Antioxidants (Basel)· January 2021

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The α7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function.
Ravikumar A Sitapara, Alex G Gauthier, Vivek S Patel, Mosi Lin, Michelle Zur

Mol Med· October 2020

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The nitric oxide donor, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate (DETA-NONOate/D-NO), increases survival by attenuating hyperoxia-compromised innate immunity in bacterial clearance in a mouse model of ventilator-associated pneumonia.
Ashwini Gore, Alex G Gauthier, Mosi Lin, Vivek Patel, Douglas D Thomas

Biochem Pharmacol· June 2020

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The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation.
Ravikumar A Sitapara, Alex G Gauthier, Sergio I Valdés-Ferrer, Mosi Lin, Vivek Patel

Mol Med· June 2020

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Unsuspecting Dietary Factors in Hyperkalemia: A Case Report on Why History Matters.
Kevin McLendon, Matthew Wiggins, Derek Hunt, Alex Gauthier, Deepu Thoppil

Clin Pract Cases Emerg Med· May 2020

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Dietary Antioxidants Significantly Attenuate Hyperoxia-Induced Acute Inflammatory Lung Injury by Enhancing Macrophage Function via Reducing the Accumulation of Airway HMGB1.
Vivek Patel, Katelyn Dial, Jiaqi Wu, Alex G Gauthier, Wenjun Wu

Int J Mol Sci· February 2020

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The Role of HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases.
Mao Wang, Alex Gauthier, LeeAnne Daley, Katelyn Dial, Jiaqi Wu

Antioxid Redox Signal· November 2019

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