Publications by authors named "Alex Gutteridge"

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Causal inference can lead us to modifiable mechanisms and informative archetypes in sepsis.
J Kenneth Baillie, Derek Angus, Katie Burnham, Thierry Calandra, Carolyn Calfee, Alex Gutteridge

Intensive Care Med· December 2024

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Network and pathway expansion of genetic disease associations identifies successful drug targets.
Aidan MacNamara, Nikolina Nakic, Ali Amin Al Olama, Cong Guo, Karsten B Sieber, Alex Gutteridge

Sci Rep· December 2020

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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.
Jie Zheng, Valeriia Haberland, Denis Baird, Venexia Walker, Philip C Haycock, Alex Gutteridge

Nat Genet· October 2020

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Redesigning Metal Interference Screws Can Improve Ease of Insertion While Maintaining Fixation of Soft-Tissue Anterior Cruciate Ligament Reconstruction Grafts.
Kiron K Athwal, Breck R Lord, Piers E Milner, Alex Gutteridge, Andy Williams

Arthrosc Sports Med Rehabil· April 2020

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Using transfer learning from prior reference knowledge to improve the clustering of single-cell RNA-Seq data.
Bettina Mieth, James R F Hockley, Nico Görnitz, Marina M-C Vidovic, Klaus-Robert Müller, Alex Gutteridge

Sci Rep· December 2019

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Benchmarking network propagation methods for disease gene identification.
Sergio Picart-Armada, Steven J Barrett, David R Willé, Alexandre Perera-Lluna, Alex Gutteridge

PLoS Comput Biol· September 2019

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Publisher Correction: Molecular and functional variation in iPSC-derived sensory neurons.
Jeremy Schwartzentruber, Stefanie Foskolou, Helena Kilpinen, Julia Rodrigues, Kaur Alasoo, Alex Gutteridge

Nat Genet· July 2019

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Single-cell RNAseq reveals seven classes of colonic sensory neuron.
James R F Hockley, Toni S Taylor, Gerard Callejo, Anna L Wilbrey, Alex Gutteridge

Gut· April 2019

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GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K ) channel opener, reduces rat dorsal root ganglion neuron excitability.
Alexandre J C Loucif, Pierre-Philippe Saintot, Jia Liu, Brett M Antonio, Shannon G Zellmer, Alex Gutteridge

Br J Pharmacol· June 2018

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Molecular and functional variation in iPSC-derived sensory neurons.
Jeremy Schwartzentruber, Stefanie Foskolou, Helena Kilpinen, Julia Rodrigues, Kaur Alasoo, Alex Gutteridge

Nat Genet· January 2018

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Transcriptomic and epigenetic regulation of disuse atrophy and the return to activity in skeletal muscle.
Andrew G Fisher, Robert A Seaborne, Thomas M Hughes, Alex Gutteridge, Claire Stewart

FASEB J· December 2017

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GWAS of self-reported mosquito bite size, itch intensity and attractiveness to mosquitoes implicates immune-related predisposition loci.
Amy V Jones, Mera Tilley, Alex Gutteridge, Craig Hyde, Michael Nagle

Hum Mol Genet· April 2017

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Directing Differentiation of Pluripotent Stem Cells Toward Retinal Pigment Epithelium Lineage.
Parul Choudhary, Heather Booth, Alex Gutteridge, Beata Surmacz, Irene Louca

Stem Cells Transl Med· February 2017

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Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.
Aristos J Alexandrou, Adam R Brown, Mark L Chapman, Mark Estacion, Jamie Turner, Alex Gutteridge

PLoS One· August 2016

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Interpreting transcriptional changes using causal graphs: new methods and their practical utility on public networks.
Carl Tony Fakhry, Parul Choudhary, Alex Gutteridge, Ben Sidders, Ping Chen

BMC Bioinformatics· August 2016

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Targeting the cAMP and Transforming Growth Factor-β Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium.
Parul Choudhary, Alex Gutteridge, Emma Impey, R Ian Storer, Robert M Owen

Stem Cells Transl Med· July 2016

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Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia.
Lishuang Cao, Aoibhinn McDonnell, Anja Nitzsche, Aristos Alexandrou, Pierre-Philippe Saintot, Alex Gutteridge

Sci Transl Med· April 2016

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A FOXM1 Dependent Mesenchymal-Epithelial Transition in Retinal Pigment Epithelium Cells.
Parul Choudhary, Benjamin Thomas Dodsworth, Ben Sidders, Alex Gutteridge, Christos Michaelides

PLoS One· March 2016

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Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation.
Alessia Tassoni, Alex Gutteridge, Amanda C Barber, Andrew Osborne, Keith R Martin

Stem Cells· October 2015

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Optimizing the leveraging of real-world data to improve the development and use of medicines.
Marc L Berger, Craig Lipset, Alex Gutteridge, Kirsten Axelsen, Prasun Subedi

Value Health· January 2015

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Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.
Gareth T Young, Alex Gutteridge, Heather DE Fox, Anna L Wilbrey, Lishuang Cao

Mol Ther· August 2014

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Precompetitive activity to address the biological data needs of drug discovery.
Ben Sidders, Christoph Brockel, Alex Gutteridge, Lee Harland, Peter Gildsig Jansen

Nat Rev Drug Discov· February 2014

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Molecular causes of transcriptional response: a Bayesian prior knowledge approach.
Kourosh Zarringhalam, Ahmed Enayetallah, Alex Gutteridge, Ben Sidders, Daniel Ziemek

Bioinformatics· December 2013

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Novel pancreatic endocrine maturation pathways identified by genomic profiling and causal reasoning.
Alex Gutteridge, J Michael Rukstalis, Daniel Ziemek, Mark Tié, Lin Ji

PLoS One· August 2013

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Directing differentiation of human embryonic stem cells toward anterior neural ectoderm using small molecules.
Beata Surmacz, Heather Fox, Alex Gutteridge, Paul Fish, Sandra Lubitz

Stem Cells· September 2012

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