Publications by authors named "Alex J Clark"

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Antisense oligonucleotides reverse SPTLC1-related hereditary sensory neuropathy in a mouse model.
Jinhong Meng, Shunyi Ma, Museer A Lone, Hou Wang Lam, Qiang Zhang, Alex J Clark

Brain· October 2025

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Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons.
Jakub Scaber, Iona Thomas-Wright, Alex J Clark, Yinyan Xu, Björn F Vahsen

Stem Cell Reports· July 2024

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Advances and challenges in modeling inherited peripheral neuropathies using iPSCs.
Jonas Van Lent, Robert Prior, Gonzalo Pérez Siles, Anthony N Cutrupi, Marina L Kennerson, Alex J Clark

Exp Mol Med· June 2024

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A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons.
Jimena Perez-Sanchez, Steven J Middleton, Luke A Pattison, Helen Hilton, Mosab Ali Awadelkareem, Alex J Clark

Sci Transl Med· October 2023

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An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions.
Alex J Clark, Umaiyal Kugathasan, Georgios Baskozos, David A Priestman, Nadine Fugger

Cell Rep Med· July 2021

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Establishing Myelinating Cocultures Using Human iPSC-Derived Sensory Neurons to Investigate Axonal Degeneration and Demyelination.
Alex J Clark

Methods Mol Biol· March 2021

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Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth.
Georgios Baskozos, Oliver Sandy-Hindmarch, Alex J Clark, Katherine Windsor, Pall Karlsson

Brain· July 2020

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The Role of Voltage-Gated Sodium Channels in Pain Signaling.
David L Bennett, Alex J Clark, Jianying Huang, Stephen G Waxman, Sulayman D Dib-Hajj

Physiol Rev· April 2019

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Defining the Functional Role of Na1.7 in Human Nociception.
Lucy A McDermott, Greg A Weir, Andreas C Themistocleous, Andrew R Segerdahl, Iulia Blesneac, Alex J Clark

Neuron· March 2019

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Comprehensive analysis of long noncoding RNA expression in dorsal root ganglion reveals cell-type specificity and dysregulation after nerve injury.
Georgios Baskozos, John M Dawes, Jean S Austin, Ana Antunes-Martins, Lucy McDermott, Alex J Clark

Pain· February 2019

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Hereditary sensory neuropathy type 1-associated deoxysphingolipids cause neurotoxicity, acute calcium handling abnormalities and mitochondrial dysfunction in vitro.
Emma R Wilson, Umaiyal Kugathasan, Andrey Y Abramov, Alex J Clark, David L H Bennett

Neurobiol Dis· September 2018

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Functional imaging in microfluidic chambers reveals sensory neuron sensitivity is differentially regulated between neuronal regions.
Alex J Clark, Guillermo Menendez, Mona AlQatari, Niral Patel, Erik Arstad

Pain· July 2018

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Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability.
John M Dawes, Greg A Weir, Steven J Middleton, Ryan Patel, Kim I Chisholm, Alex J Clark

Neuron· February 2018

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Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source.
Greg A Weir, Steven J Middleton, Alex J Clark, Tarun Daniel, Nikita Khovanov

Brain· October 2017

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Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination.
Alex J Clark, Malte S Kaller, Jorge Galino, Hugh J Willison, Simon Rinaldi

Brain· April 2017

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