Publications by authors named "Alex Jaeger"

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CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma.
Manon Chadourne, Crystal Griffith, Neel Jasani, Xiaonan Xu, Emily Brennan, Alex M Jaeger

Cell Rep· October 2025

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Pancreatic cancer-restricted cryptic antigens are targets for T cell recognition.
Zackery A Ely, Zachary J Kulstad, Gurcan Gunaydin, Sudarsana Addepalli, Eva K Verzani, Alex M Jaeger

Science· May 2025

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Aging directs the differential evolution of KRAS-driven lung adenocarcinoma.
Felicia Lazure, Stanislav Drapela, Xiaoxian Liu, John H Lockhart, Hossein Kashfi, Alex Jaeger

bioRxiv· January 2025

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CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma.
Manon Chadourne, Crystal Griffith, Xiaonan Xu, Emily Brennan, Olga Vera, Alex M Jaeger

bioRxiv· December 2024

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Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity.
Peter M K Westcott, Francesc Muyas, Haley Hauck, Olivia C Smith, Nathan J Sacks, Alex M Jaeger

Nat Genet· October 2023

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Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma.
Giorgio Gaglia, Megan L Burger, Cecily C Ritch, Danae Rammos, Yang Dai, Alex M Jaeger

Cancer Cell· May 2023

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Taking the temperature of lung cancer antigens.
Paul A Stewart, Alex M Jaeger

Nat Cancer· May 2023

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Multiscale profiling of protease activity in cancer.
Ava P Amini, Jesse D Kirkpatrick, Cathy S Wang, Alex M Jaeger, Susan Su

Nat Commun· October 2022

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Deciphering the immunopeptidome in vivo reveals new tumour antigens.
Alex M Jaeger, Lauren E Stopfer, Ryuhjin Ahn, Emma A Sanders, Demi A Sandel

Nature· July 2022

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Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer.
Srivatsan Raghavan, Peter S Winter, Andrew W Navia, Hannah L Williams, Alan DenAdel, Alex M Jaeger

Cell· December 2021

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The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer.
William A Freed-Pastor, Laurens J Lambert, Zackery A Ely, Nimisha B Pattada, Arjun Bhutkar, Alex M Jaeger

Cancer Cell· October 2021

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Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer.
Peter M K Westcott, Nathan J Sacks, Jason M Schenkel, Zackery A Ely, Olivia Smith, Alex M Jaeger

Nat Cancer· October 2021

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Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.
Yuki Nishida, Ran Zhao, Lauren E Heese, Hiroki Akiyama, Shreya Patel, Alex M Jaeger

Leukemia· September 2021

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Publisher Correction: Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes.
Alex S Genshaft, Carly G K Ziegler, Constantine N Tzouanas, Benjamin E Mead, Alex M Jaeger

Nat Commun· September 2021

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Antigen dominance hierarchies shape TCF1 progenitor CD8 T cell phenotypes in tumors.
Megan L Burger, Amanda M Cruz, Grace E Crossland, Giorgio Gaglia, Cecily C Ritch, Alex M Jaeger

Cell· September 2021

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Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes.
Alex S Genshaft, Carly G K Ziegler, Constantine N Tzouanas, Benjamin E Mead, Alex M Jaeger

Nat Commun· August 2021

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Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1.
Bushu Dong, Alex M Jaeger, Philip F Hughes, David R Loiselle, J Spencer Hauck

Sci Transl Med· December 2020

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Inhibiting Heat Shock Factor 1 in Cancer: A Unique Therapeutic Opportunity.
Bushu Dong, Alex M Jaeger, Dennis J Thiele

Trends Pharmacol Sci· December 2019

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Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation.
Alex M Jaeger, Lauren Stopfer, Sunmin Lee, Giorgio Gaglia, Demi Sandel

Clin Cancer Res· November 2019

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Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.
Rocio Gomez-Pastor, Eileen T Burchfiel, Daniel W Neef, Alex M Jaeger, Elisa Cabiscol

Nat Commun· February 2017

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Navigational Bronchoscopy for Early Lung Cancer: A Road to Therapy.
Kashif Ali Khan, Pietro Nardelli, Alex Jaeger, Conor O'Shea, Padraig Cantillon-Murphy

Adv Ther· April 2016

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Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors.
Alex M Jaeger, Charles W Pemble, Lea Sistonen, Dennis J Thiele

Nat Struct Mol Biol· February 2016

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Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.
Matthew K Howe, Khaldon Bodoor, David A Carlson, Philip F Hughes, Yazan Alwarawrah, Alex M Jaeger

Chem Biol· December 2014

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A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1.
Daniel W Neef, Alex M Jaeger, Rocio Gomez-Pastor, Felix Willmund, Judith Frydman

Cell Rep· November 2014

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Genomic heat shock element sequences drive cooperative human heat shock factor 1 DNA binding and selectivity.
Alex M Jaeger, Leah N Makley, Jason E Gestwicki, Dennis J Thiele

J Biol Chem· October 2014

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