Publications by authors named "Alex Kleinjan"

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Indocyanine-enhanced mouse model of bleomycin-induced lung fibrosis with hallmarks of progressive emphysema.
Andrea Grandi, Erica Ferrini, Laura Mecozzi, Roberta Ciccimarra, Matteo Zoboli, Alex Kleinjan

Am J Physiol Lung Cell Mol Physiol· February 2023

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Oral enoximone allows the reduction and discontinuation of inhaled steroids and beta2 agonists in asthmatic children.
Jan Beute, Alex KleinJan

Int J Pediatr Adolesc Med· June 2022

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Involvement of Dendritic Cells and Th17 Cells in Induced Tertiary Lymphoid Structures in a Chronic Beryllium Disease Mouse Model.
Alex KleinJan, Menno van Nimwegen, Karolina Leman, Ke-Xin Wen, Louis Boon

Mediators Inflamm· March 2022

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Immune checkpoint skewing might be the cause of continuous immune activation in nasal polyps: New opportunities for therapies.
Alex KleinJan

J Allergy Clin Immunol· February 2022

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Evaluation of Real-Life Investigational Use of Enoximone in Asthma, the Third Step in Drug Repurposing: A Preliminary Report.
Jan Beute, Pieter Boermans, Alex KleinJan

Can Respir J· January 2022

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Phosphodiesterase-3 Inhibitor Enoximone in SARS-CoV-2 Infection.
Jan Beute, Alex KleinJan

J Aerosol Med Pulm Drug Deliv· September 2021

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Impaired pulmonary vasomotor control in exercising swine with multiple comorbidities.
Jens van de Wouw, Jarno J Steenhorst, Oana Sorop, Ruben W A van Drie, Piotr A Wielopolski, Alex Kleinjan

Basic Res Cardiol· September 2021

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SSC-ILD mouse model induced by osmotic minipump delivered bleomycin: effect of Nintedanib.
Francesca Ravanetti, Erica Ferrini, Luisa Ragionieri, Zahra Khalajzeyqami, Maria Nicastro, Alex Kleinjan

Sci Rep· September 2021

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PDE3-inhibitor enoximone prevented mechanical ventilation in patients with SARS-CoV-2 pneumonia.
Jan Beute, Pieter Boermans, Bart Benraad, Jan Telman, Zuzana Diamant, Alex KleinJan

Exp Lung Res· April 2021

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Notch signaling licenses allergic airway inflammation by promoting Th2 cell lymph node egress.
Irma Tindemans, Anne van Schoonhoven, Alex KleinJan, Marjolein Jw de Bruijn, Melanie Lukkes

J Clin Invest· July 2020

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PDE3 Inhibition Reduces Epithelial Mast Cell Numbers in Allergic Airway Inflammation and Attenuates Degranulation of Basophils and Mast Cells.
Jan Beute, Keerthana Ganesh, Hedwika Nastiti, Robin Hoogenboom, Vivica Bos, Alex KleinJan

Front Pharmacol· May 2020

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Stuck in the MUC: Infinity loop of fucosylation in allergic airway inflammation.
Alex KleinJan

J Allergy Clin Immunol· September 2019

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Increased surface expression of NOTCH on memory T cells in peripheral blood from patients with asthma.
Irma Tindemans, Heleen Vroman, Melanie Lukkes, Menno van Nimwegen, Marjolein J W de Bruijn, Alex Kleinjan

J Allergy Clin Immunol· February 2019

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T cells and ILC2s are major effector cells in influenza-induced exacerbation of allergic airway inflammation in mice.
Bobby W S Li, Marjolein J W de Bruijn, Melanie Lukkes, Menno van Nimwegen, Ingrid M Bergen, Alex KleinJan

Eur J Immunol· January 2019

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The Notch pathway inhibitor stapled α-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma.
Alex KleinJan, Irma Tindemans, Jeffrey E Montgomery, Melanie Lukkes, Marjolein J W de Bruijn

J Allergy Clin Immunol· July 2018

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Increased T-helper 17.1 cells in sarcoidosis mediastinal lymph nodes.
Caroline E Broos, Laura L Koth, Menno van Nimwegen, Johannes C C M In 't Veen, Sandra M J Paulissen, Alex Kleinjan

Eur Respir J· March 2018

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DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients.
Leen J M Seys, W Widagdo, Fien M Verhamme, Alex Kleinjan, Wim Janssens

Clin Infect Dis· January 2018

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A pathophysiological role of PDE3 in allergic airway inflammation.
Jan Beute, Melanie Lukkes, Ewout P Koekoek, Hedwika Nastiti, Keerthana Ganesh, Alex KleinJan

JCI Insight· January 2018

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Group 2 Innate Lymphoid Cells Exhibit a Dynamic Phenotype in Allergic Airway Inflammation.
Bobby W S Li, Ralph Stadhouders, Marjolein J W de Bruijn, Melanie Lukkes, Dior M J M Beerens, Alex KleinJan

Front Immunol· December 2017

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Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable.
Irma Tindemans, Melanie Lukkes, Marjolein J W de Bruijn, Bobby W S Li, Menno van Nimwegen, Alex KleinJan

J Allergy Clin Immunol· October 2017

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Longitudinal assessment of bleomycin-induced lung fibrosis by Micro-CT correlates with histological evaluation in mice.
Francesca Ruscitti, Francesca Ravanetti, Jeroen Essers, Yanto Ridwan, Sasha Belenkov, Alex KleinJan

Multidiscip Respir Med· April 2017

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T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice.
Bobby W S Li, Marjolein J W de Bruijn, Irma Tindemans, Melanie Lukkes, Alex KleinJan

Eur J Immunol· June 2016

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Airway inflammation in asthma: key players beyond the Th2 pathway.
Alex KleinJan

Curr Opin Pulm Med· January 2016

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Impaired survival of regulatory T cells in pulmonary sarcoidosis.
Caroline E Broos, Menno van Nimwegen, Alex Kleinjan, Bregje ten Berge, Femke Muskens

Respir Res· September 2015

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Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema.
Natasja W M Ramnath, Koen M van de Luijtgaarden, Ingrid van der Pluijm, Menno van Nimwegen, Paula M van Heijningen, Alex Kleinjan

PLoS One· June 2015

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