Publications by authors named "Alex Rafacho"

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Commercial glyphosate formulations exceed active ingredient toxicity via mitochondrial ROS and transcriptomic disruption.
Jakeline Liara Teleken, Leticia Prates Roma, Rosane Aparecida Ribeiro, Alex Rafacho, Maria Lúcia Bonfleur

Toxicol In Vitro· March 2026

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Sex-Specific Differences in the Revascularization of Grafted Pancreatic Islets.
Selina Wrublewsky, Annika Valerie Widmann, Caroline Bickelmann, Alex Rafacho, Leticia Prates Roma

Cells· August 2025

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Intranasal pramlintide matches intraperitoneal effects on food intake and gastric emptying in mice.
Milena S Almeida, Mariele P Sanches, Natália S Tonet, Carine Zuglianello, Joseane Morari, Alex Rafacho

Endocrine· July 2025

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Structural Concepts, Definition, Classification, and Macronutrient and Food Composition of Carbohydrate-Restricted Diets for Individuals with Type 2 Diabetes Mellitus: A Scoping Review.
Fharlley Lohann Medeiros, Ana Carolina Fernandes, Mariana V S Kraemer, Marina Padovan, Greyce Luci Bernardo, Alex Rafacho

Nutrients· March 2025

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Hyperglucagonemia and glucagon hypersecretion in early type 2 diabetes result from multifaceted dysregulation of pancreatic mouse α-cells.
Antonia Ruiz-Pino, Arianna Goncalves-Ramírez, Margarita Jiménez-Palomares, Beatriz Merino, Manuel Castellano-Muñoz, Alex Rafacho

Pflugers Arch· February 2025

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Hepatocyte nuclear factor 4-α is necessary for high fat diet-induced pancreatic β-cell mass expansion and metabolic compensations.
Francieli Caroline de Ramos, Robson Barth, Marcos Rizzon Santos, Milena Dos Santos Almeida, Sandra Mara Ferreira, Alex Rafacho

Front Endocrinol (Lausanne)· January 2025

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Twenty-four weeks of combined training in different environments, aquatic and land, in the type 2 diabetes management (Aquatic and Land Exercise for Diabetes -ALED): protocol of a randomized clinical trial.
Larissa Dos Santos Leonel, Ingrid Alessandra Victoria Wolin, Angélica Danielevicz, Mabel Diesel, Marina Isolde Constantini, Alex Rafacho

Trials· January 2025

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Moderate chronic sleep perturbation impairs glucose and lipid homeostasis in rats.
Natália Stinghen Tonet, Danilo Francisco da Silva Marçal, Flavia Natividade da Silva, Henver Simionato Brunetta, Marcelo Alves da Silva Mori, Alex Rafacho

Sleep· July 2024

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Zein nanoparticles as oral carrier for mometasone furoate delivery.
Priscila Zimath, Soraia Pinto, Sofia Dias, Alex Rafacho, Bruno Sarmento

Drug Deliv Transl Res· November 2023

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Coadministration of olanzapine causes minor impacts on the diabetogenic outcomes induced by dexamethasone treatment in rats.
Flávia Natividade da Silva, Priscila Laiz Zimath, Thais Alves do Amaral, José Rodrigo Nascimento Martins, Alex Rafacho

Life Sci· June 2023

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Oral mometasone furoate administration preserves anti-inflammatory action with fewer metabolic adverse effects in rats.
Priscila L Zimath, Milena S Almeida, Maciel A Bruxel, Alex Rafacho

Biochem Pharmacol· April 2023

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Preconception exposure to malathion and glucose homeostasis in rats: Effects on dams during pregnancy and post-term periods, and on their progeny.
Maciel Alencar Bruxel, Flávia Natividade da Silva, Rodrigo Augusto da Silva, Priscila Laiz Zimath, Anabel Rojas, Alex Rafacho

Environ Pollut· January 2023

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Glucocorticoids and glucolipotoxicity alter the DNA methylome and function of human EndoC-βH1 cells.
Cristiane Dos Santos, Alexandros Karagiannopoulos, Alex Rafacho, Alexander Perfilyev, Lena Eliasson

Life Sci· October 2022

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Antidepressant-like activity of gestational administration of vitamin D is suppressed by prenatal overexposure to dexamethasone in female Wistar rats.
Tamires Gregorio, Flaviano Lorenzon, Fernanda Niebisch, Rafaela Carla Kachel Stolte, Alex Rafacho

Physiol Behav· May 2022

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The effects of macronutrients composition on hormones and substrates during a meal tolerance test in drugnaive and sitagliptin-treated individuals with type 2 diabetes: a randomized crossover study.
Cristina da Silva Schreiber, Alex Rafacho, Renata Silverio, Roberto Betti, Antonio Carlos Lerário

Arch Endocrinol Metab· May 2022

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Pep19 Has a Positive Effect on Insulin Sensitivity and Ameliorates Both Hepatic and Adipose Tissue Phenotype of Diet-Induced Obese Mice.
Renata Silvério, Robson Barth, Andrea S Heimann, Patrícia Reckziegel, Gustavo J Dos Santos, Alex Rafacho

Int J Mol Sci· April 2022

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The Effects of Aging on Male Mouse Pancreatic β-Cell Function Involve Multiple Events in the Regulation of Secretion: Influence of Insulin Sensitivity.
Eva Tudurí, Sergi Soriano, Lucía Almagro, Anabel García-Heredia, Alex Rafacho

J Gerontol A Biol Sci Med Sci· March 2022

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Coadministration of sitagliptin or metformin has no major impact on the adverse metabolic outcomes induced by dexamethasone treatment in rats.
Bryanne Silva Figueiredo, Francielle Batista D Ferreira, Amanda Marreiro Barbosa, Cristiane Dos Santos, Henrik Ortsäter, Alex Rafacho

Life Sci· December 2021

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Maternal vitamin D administration attenuates metabolic disturbances induced by prenatal exposure to dexamethasone in a sex-dependent manner.
Flaviano Lorenzon, Tamires Gregorio, Fernanda Niebisch, Rafaela C K Stolte, Gustavo J Dos Santos, Alex Rafacho

J Steroid Biochem Mol Biol· September 2021

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Excess of glucocorticoids during late gestation impairs the recovery of offspring's β-cell function after a postnatal injury.
Cristiane Dos Santos, Alex Rafacho, Sandra Mara Ferreira, Jean Franciesco Vettorazzi, Thiago Dos Reis Araújo

FASEB J· August 2021

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Reduced insulin sensitivity and increased β/α cell mass is associated with reduced hepatic insulin-degrading enzyme activity in pregnant rats.
Ana P D Taschetto, Priscila L Zimath, Renata Silvério, Cristiane Dos Santos, Antonio C Boschero, Alex Rafacho

Life Sci· July 2021

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Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration.
Cristiane Dos Santos, Julia Spanhol da Silva, Henver Simionato Brunetta, Thays Rodrigues Chagas, Daniel Breseghello Zoccal, Alex Rafacho

J Nutr Biochem· April 2021

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COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice.
Rosângela Mayer Gonçalves, Marina Delgobo, Jonathan Paulo Agnes, Raquel Nascimento das Neves, Marcelo Falchetti, Alex Rafacho

Cancer Lett· April 2021

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Impact of different fructose concentrations on metabolic and behavioral parameters of male and female mice.
Letícia De Souza, Wellinghton de Medeiros Barros, Raul Marin De Souza, Eslen Delanogare, Adriano Emanuel Machado, Alex Rafacho

Physiol Behav· January 2021

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Gestational exposure to excessive levels of dexamethasone impairs maternal care and impacts on the offspring's survival in rats.
Elisa C Cella, Júlia Conte, Rafaela C K Stolte, Flaviano Lorenzon, Tamires Gregorio, Alex Rafacho

Life Sci· January 2021

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