Publications by authors named "Alex Scopton"

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A stress-responsive p38 signaling axis in choanoflagellates.
Florentine U Rutaganira, Maxwell C Coyle, Maria H T Nguyen, Iliana Hernandez, Alex P Scopton

RSC Chem Biol· June 2025

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WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma.
Alex Rialdi, Mary Duffy, Alex P Scopton, Frank Fonseca, Julia Nanyi Zhao

Nat Cancer· August 2023

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Type II Binders Targeting the "GLR-Out" Conformation of the Pseudokinase STRADα.
Ryan H B Smith, Zaigham M Khan, Peter Man-Un Ung, Alex P Scopton, Lisa Silber

Biochemistry· February 2021

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Structural basis for the action of the drug trametinib at KSR-bound MEK.
Zaigham M Khan, Alexander M Real, William M Marsiglia, Arthur Chow, Mary E Duffy, Alex P Scopton

Nature· December 2020

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Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network.
Peter M U Ung, Masahiro Sonoshita, Alex P Scopton, Arvin C Dar, Ross L Cagan

PLoS Comput Biol· April 2019

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A whole-animal platform to advance a clinical kinase inhibitor into new disease space.
Masahiro Sonoshita, Alex P Scopton, Peter M U Ung, Matthew A Murray, Lisa Silber

Nat Chem Biol· March 2018

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Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling.
Neil S Dhawan, Alex P Scopton, Arvin C Dar

Nature· September 2016

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Identification of novel functionally selective κ-opioid receptor scaffolds.
Kate L White, Alex P Scopton, Marie-Laure Rives, Ruslan V Bikbulatov, Prabhakar R Polepally

Mol Pharmacol· January 2014

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Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Wenyu Yu, Emma J Chory, Amy K Wernimont, Wolfram Tempel, Alex Scopton

Nat Commun· June 2013

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Enantioselective pathway for the synthesis of laurenditerpenol.
Santanu Mukherjee, Alex P Scopton, E J Corey

Org Lett· April 2010

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Synthesis of HKI 0231B.
Alex Scopton, T Ross Kelly

J Org Chem· November 2005

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Synthesis of azacridone A.
Alex Scopton, T Ross Kelly

Org Lett· October 2004

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