Publications by authors named "Alex Toftgaard Nielsen"

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Analysis of Proteome Dynamics in Early-Stage Sporulation-Inhibited Variants of .
Marie Millgaard, Oihane Irazoki, Viviënne Mol, Ivan Pogrebnyakov, Alex Toftgaard Nielsen

Int J Mol Sci· December 2025

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The engineering toolbox of Parageobacillus thermoglucosidasius.
Marie Millgaard, Belinda Escher, Ivan Pogrebnyakov, Alex Toftgaard Nielsen

Appl Microbiol Biotechnol· July 2025

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Metabolic engineering of Parageobacillus thermoglucosidasius for thermophilic production of 1-butanol.
Pablo Doménech, Ivan Pogrebnyakov, Sheila Ingemann Jensen, Jasper L S P Driessen, Anders Riisager, Alex Toftgaard Nielsen

AMB Express· May 2025

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Biocatalysis with In-Situ Product Removal Improves p-Coumaric Acid Production.
Alexander Virklund, Alex Toftgaard Nielsen, John M Woodley

Chembiochem· October 2024

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Modulating metabolism through synthetic biology: Opportunities for two-stage fermentation.
Yixin Rong, Sheila Ingemann Jensen, John M Woodley, Alex Toftgaard Nielsen

Biotechnol Bioeng· October 2024

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CRISPRi-mediated metabolic switch enables concurrent aerobic and synthetic anaerobic fermentations in engineered consortium.
Yixin Rong, Adrian Frey, Emre Özdemir, Arrate Sainz de la Maza Larrea, Songyuan Li, Alex Toftgaard Nielsen

Nat Commun· October 2024

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Probing efficient microbial CO utilisation through metabolic and process modelling.
Philip J Gorter de Vries, Viviënne Mol, Nikolaus Sonnenschein, Torbjørn Ølshøj Jensen, Alex Toftgaard Nielsen

Microb Biotechnol· February 2024

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Characterization of tyrosine ammonia lyases from Flavobacterium johnsonian and Herpetosiphon aurantiacus.
Alexander Virklund, Christian Bille Jendresen, Alex Toftgaard Nielsen, John M Woodley

Biotechnol J· November 2023

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An improved integrative GFP-based vector for genetic engineering of Parageobacillus thermoglucosidasius facilitates the identification of a key sporulation regulator.
Marie Millgaard, Gonzalo Nahuel Bidart, Ivan Pogrebnyakov, Alex Toftgaard Nielsen, Ditte Hededam Welner

AMB Express· May 2023

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Folding of heterologous proteins in bacterial cell factories: Cellular mechanisms and engineering strategies.
Yixin Rong, Sheila Ingemann Jensen, Kresten Lindorff-Larsen, Alex Toftgaard Nielsen

Biotechnol Adv· February 2023

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High-throughput colorimetric assays optimized for detection of ketones and aldehydes produced by microbial cell factories.
Ekaterina Kozaeva, Viviënne Mol, Pablo I Nikel, Alex Toftgaard Nielsen

Microb Biotechnol· September 2022

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The ProUSER2.0 Toolbox: Genetic Parts and Highly Customizable Plasmids for Synthetic Biology in .
Kristoffer Bach Falkenberg, Viviënne Mol, Arrate Sainz de la Maza Larrea, Ivan Pogrebnyakov, Morten H H Nørholm, Alex Toftgaard Nielsen

ACS Synth Biol· December 2021

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A dual-reporter system for investigating and optimizing protein translation and folding in E. coli.
Ariane Zutz, Louise Hamborg, Lasse Ebdrup Pedersen, Maher M Kassem, Elena Papaleo, Alex Toftgaard Nielsen

Nat Commun· October 2021

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Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli.
Louise Hamborg, Daniele Granata, Johan G Olsen, Jennifer Virginia Roche, Lasse Ebdrup Pedersen, Alex Toftgaard Nielsen

Commun Biol· August 2021

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Genome-scale metabolic modeling of P. thermoglucosidasius NCIMB 11955 reveals metabolic bottlenecks in anaerobic metabolism.
Viviënne Mol, Martyn Bennett, Benjamín J Sánchez, Beata K Lisowska, Markus J Herrgård, Alex Toftgaard Nielsen

Metab Eng· May 2021

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CRISPR interference of nucleotide biosynthesis improves production of a single-domain antibody in Escherichia coli.
Jenny Landberg, Naia Risager Wright, Tune Wulff, Markus J Herrgård, Alex Toftgaard Nielsen

Biotechnol Bioeng· December 2020

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An autoinducible trp-T7 expression system for production of proteins and biochemicals in Escherichia coli.
Jenny Landberg, Hemanshu Mundhada, Alex Toftgaard Nielsen

Biotechnol Bioeng· May 2020

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Genome-Wide CRISPRi-Based Identification of Targets for Decoupling Growth from Production.
Songyuan Li, Christian Bille Jendresen, Jenny Landberg, Lasse Ebdrup Pedersen, Nikolaus Sonnenschein, Alex Toftgaard Nielsen

ACS Synth Biol· May 2020

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Production of zosteric acid and other sulfated phenolic biochemicals in microbial cell factories.
Christian Bille Jendresen, Alex Toftgaard Nielsen

Nat Commun· September 2019

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Genome-wide systematic identification of methyltransferase recognition and modification patterns.
Torbjørn Ølshøj Jensen, Christian Tellgren-Roth, Stephanie Redl, Jérôme Maury, Simo Abdessamad Baallal Jacobsen, Alex Toftgaard Nielsen

Nat Commun· August 2019

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Generation of an E. coli platform strain for improved sucrose utilization using adaptive laboratory evolution.
Elsayed T Mohamed, Hemanshu Mundhada, Jenny Landberg, Isaac Cann, Roderick I Mackie, Alex Toftgaard Nielsen

Microb Cell Fact· June 2019

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Extraction, Enrichment, and in situ Electrochemical Detection on Lab-on-a-Disc: Monitoring the Production of a Bacterial Secondary Metabolite.
Sune Zoëga Andreasen, Kuldeep Sanger, Christian Bille Jendresen, Alex Toftgaard Nielsen, Jenny Emnéus

ACS Sens· February 2019

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Simultaneous quantification of multiple bacterial metabolites using surface-enhanced Raman scattering.
Lidia Morelli, Francesca Alessandra Centorbi, Oleksii Ilchenko, Christian Bille Jendresen, Danilo Demarchi, Alex Toftgaard Nielsen

Analyst· February 2019

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Multiplex Genome Editing in Escherichia coli.
Sheila Ingemann Jensen, Alex Toftgaard Nielsen

Methods Mol Biol· July 2018

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Injection molded lab-on-a-disc platform for screening of genetically modified E. coli using liquid-liquid extraction and surface enhanced Raman scattering.
Lidia Morelli, Laura Serioli, Francesca Alessandra Centorbi, Christian Bille Jendresen, Marco Matteucci, Alex Toftgaard Nielsen

Lab Chip· March 2018

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