Publications by authors named "Alex Toker"

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Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion.
Fen Ma, Sen Chen, Luigi Cecchi, Betul Ersoy-Fazlioglu, Joshua W Russo, Alex Toker

J Clin Invest· December 2025

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The glycosyltransferase ALG3 is an AKT substrate that regulates protein N-glycosylation.
Adrija J Navarro-Traxler, Laura Ghisolfi, Evan C Lien, Alex Toker

J Biol Chem· September 2025

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Lessons from the Oncology Clinic: Repurposing PI3K Pathway Inhibitors for the Treatment of PTEN Hamartoma Tumor Syndrome.
Isabella Del Priore, Alex Toker

Cancer Discov· July 2025

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Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion.
Fen Ma, Sen Chen, Luigi Cecchi, Betul Ersoy-Fazlioglu, Joshua Russo, Alex Toker

bioRxiv· July 2025

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Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity.
Tigist Y Tamir, Shreya Chaudhary, Annie X Li, Sonia E Trojan, Cameron T Flower, Alex Toker

Mol Cell· June 2025

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The glycosyltransferase ALG3 is an AKT substrate that regulates protein N-glycosylation.
Adrija J Navarro-Traxler, Laura Ghisolfi, Evan C Lien, Alex Toker

bioRxiv· April 2025

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Parallel phosphoproteomics and metabolomics map the global metabolic tyrosine phosphoproteome.
Alissandra L Hillis, Tigist Tamir, Grace E Perry, John M Asara, Jared L Johnson, Alex Toker

Proc Natl Acad Sci U S A· November 2024

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Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer.
Alissandra L Hillis, Timothy D Martin, Haley E Manchester, Jenny Högström, Na Zhang, Alex Toker

Cancer Res· October 2024

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Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity.
Tigist Y Tamir, Shreya Chaudhary, Annie X Li, Sonia E Trojan, Cameron T Flower, Alex Toker

bioRxiv· August 2024

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Minimizing Shear Stress in Cell Signaling Studies.
Josefina Mendez, Alex Toker

Curr Protoc· March 2024

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Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation.
Emily C Erickson, Inchul You, Grace Perry, Aurelien Dugourd, Katherine A Donovan, Alex Toker

Sci Signal· February 2024

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PI3K signaling through a biochemical systems lens.
Ralitsa R Madsen, Alex Toker

J Biol Chem· October 2023

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Generative artificial intelligence in Journal of Biological Chemistry.
Roger J Colbran, Alex Toker

J Biol Chem· August 2023

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JAK-STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States.
Laura E Stevens, Guillermo Peluffo, Xintao Qiu, Daniel Temko, Anne Fassl, Alex Toker

Cancer Res· January 2023

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PI3K drives the de novo synthesis of coenzyme A from vitamin B5.
Christian C Dibble, Samuel A Barritt, Grace E Perry, Evan C Lien, Renee C Geck, Alex Toker

Nature· August 2022

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The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia.
Yan Xu, Houshun Fang, Yao Chen, Yabin Tang, Huiying Sun, Alex Toker

iScience· March 2022

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Can open science follow open access?
Alex Toker

J Biol Chem· January 2022

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WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models.
Takahiro Kishikawa, Hiroshi Higuchi, Limei Wang, Nivedita Panch, Valerie Maymi, Alex Toker

J Clin Invest· December 2021

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Can Improved Use of Biomarkers Alter the Fate of PI3K Pathway Inhibitors in the Clinic?
Emily C Erickson, Alex Toker

Cancer Res· December 2021

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FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance.
Yihao Li, Xintao Qiu, Xiaoqing Wang, Hui Liu, Renee C Geck, Alex Toker

Nat Cell Biol· November 2021

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Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype.
Ralitsa R Madsen, Emily C Erickson, Oscar M Rueda, Xavier Robin, Carlos Caldas, Alex Toker

PLoS Genet· November 2021

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Lactate Lights up PI3K Inhibitor Resistance in Breast Cancer.
Alissandra L Hillis, Alex Toker

Cancer Cell· October 2020

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Metabolic pathway alterations in microvascular endothelial cells in response to hypoxia.
Emily B Cohen, Renee C Geck, Alex Toker

PLoS One· September 2020

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The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
Hui Liu, Marcia N Paddock, Haibin Wang, Charles J Murphy, Renee C Geck, Alex Toker

Cancer Discov· August 2020

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Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy.
Renee C Geck, Jackson R Foley, Tracy Murray Stewart, John M Asara, Robert A Casero, Alex Toker

J Biol Chem· May 2020

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