Publications by authors named "Alexander A Sousa"

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Search-and-replace genome editing without double-strand breaks or donor DNA.
Andrew V Anzalone, Peyton B Randolph, Jessie R Davis, Alexander A Sousa, Luke W Koblan, Jonathan M Levy, Peter J Chen, Christopher Wilson, Gregory A Newby, Aditya Raguram

Nature· December 2019

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In vivo prime editing rescues alternating hemiplegia of childhood in mice.
Alexander A Sousa, Markus Terrey, Holt A Sakai, Christine Q Simmons, Elena Arystarkhova

Cell· August 2025

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Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells.
Alexander A Sousa, Colin Hemez, Lei Lei, Soumba Traore, Katarina Kulhankova

Nat Biomed Eng· January 2025

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Author Correction: Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos.
Liang Chen, Mengjia Hong, Changming Luan, Hongyi Gao, Gaomeng Ru, Alexander A Sousa

Nat Biotechnol· June 2024

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Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos.
Liang Chen, Mengjia Hong, Changming Luan, Hongyi Gao, Gaomeng Ru, Alexander A Sousa

Nat Biotechnol· April 2024

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Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice.
Kelcee A Everette, Gregory A Newby, Rachel M Levine, Kalin Mayberry, Yoonjeong Jang, Alexander A Sousa

Nat Biomed Eng· May 2023

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Designing and executing prime editing experiments in mammalian cells.
Jordan L Doman, Alexander A Sousa, Peyton B Randolph, Peter J Chen, David R Liu

Nat Protoc· November 2022

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Publisher Correction: Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing.
Benjamin P Kleinstiver, Alexander A Sousa, Russell T Walton, Y Esther Tak, Jonathan Y Hsu

Nat Biotechnol· July 2020

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High levels of AAV vector integration into CRISPR-induced DNA breaks.
Killian S Hanlon, Benjamin P Kleinstiver, Sara P Garcia, Mikołaj P Zaborowski, Adrienn Volak, Alexander A Sousa

Nat Commun· September 2019

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Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing.
Benjamin P Kleinstiver, Alexander A Sousa, Russell T Walton, Y Esther Tak, Jonathan Y Hsu

Nat Biotechnol· March 2019

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Discovery of widespread type I and type V CRISPR-Cas inhibitors.
Nicole D Marino, Jenny Y Zhang, Adair L Borges, Alexander A Sousa, Lina M Leon

Science· October 2018

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Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs.
Jennifer Listgarten, Michael Weinstein, Benjamin P Kleinstiver, Alexander A Sousa, J Keith Joung

Nat Biomed Eng· January 2018

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Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
Janice S Chen, Yavuz S Dagdas, Benjamin P Kleinstiver, Moira M Welch, Alexander A Sousa

Nature· October 2017

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