Nature December 2019 PMID 31634902

Search-and-replace genome editing without double-strand breaks or donor DNA.

Andrew V Anzalone, Peyton B Randolph, Jessie R Davis, Alexander A Sousa, Luke W Koblan, Jonathan M Levy, Peter J Chen, Christopher Wilson, Gregory A Newby, Aditya Raguram, David R Liu

Mentions

477
Peak: 78 in Oct 2019
across 6 sources since Oct 2019

Extended reach

341,636
potential audience

Total likes

399

Video views

20,883

Mentions per month

Oct 2019 – May 2025

Where it's discussed

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AI synopsis

What people are saying

Many discussions highlight the innovative aspects of prime editing, such as the ability to make single-strand cuts while reducing unintended errors. Phrases like 'game changer' and 'genetic engineering revolution' are used to convey excitement and the potential for significant advancements in treating genetic diseases. The tone is predominantly optimistic, illustrating both a fascination with the technology and an acknowledgment of the responsibilities it entails.

AgreementStrong agreement

A majority of discussions express strong support for the methodologies presented in the publication, highlighting its advantages over previous gene editing techniques.

InterestHigh interest

Posts reflect high levels of curiosity, indicating a strong desire to learn about and explore prime editing.

EngagementHigh engagement

Many contributors discuss the specifics of prime editing and its applications in detail, suggesting a deeper understanding and contemplation of the material.

ImpactHigh impact

The community perceives this advancement as having a significant impact on the field of genetic engineering and healthcare.

Abstract in brief

  • Prime editing is a precise genome editing technique that allows for the direct insertion of new genetic information at specific DNA sites without causing double-strand breaks or using donor DNA templates.
  • The method has successfully conducted over 175 edits in human cells, including various mutations and corrections for diseases like sickle cell and Tay-Sachs, while maintaining a low level of byproducts.
  • Compared to traditional methods like homology-directed repair and base editing, prime editing offers higher efficiency, fewer unintended changes, and has the potential to address a significant number of genetic variants linked to human diseases.

Top posts

Most liked on X and Bluesky
DNA&RNA Universe
@DNA_RNA_Uni · X

Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing" annotated to be more precise and more efficient than CRISPR

Dec 30, 2019 · 29 likes · 13 shares · 39,374 followers View post →
Wei Zhao
@zhaoweiasu · X

Exactly 3 years ago, the seminal Prime Editing paper was published in Nature. Yesterday, Prime Medicine successfully completed its IPO.

Oct 21, 2022 · 20 likes · 3 shares · 6,474 followers View post →
TRGENMER
@trgenmer · X

#SMA Ekibimizden @cemrecaninci @ozumkilic @haleahsenbabar "Search-and-Replace Genome Editing Without Double-Strand Breaks or Donor DNA" isimli sunumlarını gerçekleştirdi. Araştırmacılarımıza deneylerinde başarılar dileriz. #TRGENMER @uskudaruni @CihanTastan_PhD https://t.co/gBt61st5rq

Mar 1, 2023 · 14 likes · 4 shares · 544 followers View post →
Lev Kats
@LevKats · X

Really incredible stuff, going to make a lot of things possible! Can’t wait to start playing with this. Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/fjAAWrtedC

Oct 23, 2019 · 6 likes · 2 shares · 407 followers View post →
N
@nosignul · X

@Biotech2k1 @toby_crooks @kernytsky Anzalone et al https://t.co/CjDJHWxYnI

Jul 13, 2021 · 2 likes · 11,919 followers View post →
GEFSES_CREATE
@gefses_create · X

"Search-and-replace genome editing without double-strand breaks or donor DNA" @nresearchnews https://t.co/jTxGEqLAoE

Oct 23, 2019 · 2 likes · 1 share · 180 followers View post →

All mentions

Thamarasee Jeewandara
@Jeew333T · X

Key paper: Prime editing - search and replace genome editing without double-strand breaks or donor DNA. https://t.co/4UMvYVfGHo Prime editing expands the scope of genome editing, and in principle can correct up to 89% of known genetic variants associated with human diseases.

Jun 8, 2024 · 1,289 followers View post →
22Q11 Ireland
@22Q11_Ireland · X

Search-and-replace genome editing without double-strand breaks or donor DNA #PrimeEditing https://t.co/e5YRAlOXR1

May 7, 2024 · 4,765 followers View post →
Alexander Jacobson
@ajtweet · X

Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/q4zvjPhMv4

Apr 15, 2023 · 1,262 followers View post →
Cihan Taştan, PhD
@CihanTastan_PhD · X

RT @trgenmer: #SMA Ekibimizden @cemrecaninci @ozumkilic @haleahsenbabar "Search-and-Replace Genome Editing Without Double-Strand Breaks or…

Mar 1, 2023 · 4 shares · 27,004 followers View post →
Özüm Kılıç
@ozumkilic · X

RT @trgenmer: #SMA Ekibimizden @cemrecaninci @ozumkilic @haleahsenbabar "Search-and-Replace Genome Editing Without Double-Strand Breaks or…

Mar 1, 2023 · 4 shares · 357 followers View post →
HALE AHSEN BABAR
@haleahsenbabar · X

RT @trgenmer: #SMA Ekibimizden @cemrecaninci @ozumkilic @haleahsenbabar "Search-and-Replace Genome Editing Without Double-Strand Breaks or…

Mar 1, 2023 · 4 shares · 248 followers View post →
JFR
@JFR0007 · X

RT @trgenmer: #SMA Ekibimizden @cemrecaninci @ozumkilic @haleahsenbabar "Search-and-Replace Genome Editing Without Double-Strand Breaks or…

Mar 1, 2023 · 4 shares · 195 followers View post →
TRGENMER
@trgenmer · X

#SMA Ekibimizden @cemrecaninci @ozumkilic @haleahsenbabar "Search-and-Replace Genome Editing Without Double-Strand Breaks or Donor DNA" isimli sunumlarını gerçekleştirdi. Araştırmacılarımıza deneylerinde başarılar dileriz. #TRGENMER @uskudaruni @CihanTastan_PhD https://t.co/gBt61st5rq

Mar 1, 2023 · 14 likes · 4 shares · 544 followers View post →
Andre-ACGT
@Andre_AGTC · X

RT @zhaoweiasu: Exactly 3 years ago, the seminal Prime Editing paper was published in Nature. Yesterday, Prime Medicine successfully comp…

Oct 21, 2022 · 3 shares · 6,043 followers View post →
Rolando A Moreno
@RolandoAMoreno · X

RT @zhaoweiasu: Exactly 3 years ago, the seminal Prime Editing paper was published in Nature. Yesterday, Prime Medicine successfully comp…

Oct 21, 2022 · 3 shares · 320 followers View post →
SAMi
@msamiozaydin · X

RT @zhaoweiasu: Exactly 3 years ago, the seminal Prime Editing paper was published in Nature. Yesterday, Prime Medicine successfully comp…

Oct 21, 2022 · 3 shares · 241 followers View post →
Wei Zhao
@zhaoweiasu · X

Exactly 3 years ago, the seminal Prime Editing paper was published in Nature. Yesterday, Prime Medicine successfully completed its IPO.

Oct 21, 2022 · 20 likes · 3 shares · 6,474 followers View post →
SLS
@Rombicub · X

Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/h3zsKKy9YR

Oct 24, 2021 · 933 followers View post →
N
@nosignul · X

@Biotech2k1 @toby_crooks @kernytsky Anzalone et al https://t.co/CjDJHWxYnI

Jul 13, 2021 · 2 likes · 11,919 followers View post →
Dariel Ashton-Beaucage, PhD
@darielab · X

RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/EFO5ONmEnR https:/…

Jan 26, 2020 · 31 shares · 141 followers View post →
luis hernan graffe
@hernangraffe · X

RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…

Jan 17, 2020 · 13 shares · 3,124 followers View post →
Dave Grawoig, Ph.D.
@grawoig · X

RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…

Jan 16, 2020 · 13 shares · 6,554 followers View post →
Dave Grawoig, Ph.D.
@grawoig · X

RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…

Jan 7, 2020 · 13 shares · 6,554 followers View post →
Ignacio Ramos Díaz
@iramosdiaz · X

RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…

Dec 31, 2019 · 13 shares · 377 followers View post →
Prof Zoë Waller
@DrZoeWaller · X

RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…

Dec 31, 2019 · 13 shares · 2,345 followers View post →
Michelle
@Michellisu_2018 · X

RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…

Dec 30, 2019 · 13 shares · 124 followers View post →
Juliana Rolon
@JulianaRolon · X

RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…

Dec 30, 2019 · 13 shares · 942 followers View post →
م. محمد العقيلي
@MohdAlaqeili · X

RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…

Dec 30, 2019 · 13 shares · 3,249 followers View post →
Ganjasmoker
@GanjasmokerCb · X

RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…

Dec 30, 2019 · 13 shares · 2,321 followers View post →
luis hernan graffe
@hernangraffe · X

RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…

Dec 30, 2019 · 13 shares · 3,124 followers View post →
MaizeZynski Hawaii
@MaizeZynskiHI · X

RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…

Dec 30, 2019 · 13 shares · 1,973 followers View post →
Dave Grawoig, Ph.D.
@grawoig · X

RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…

Dec 30, 2019 · 13 shares · 6,554 followers View post →
Eduardo Villalobo
@ptu_us_es · X

RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…

Dec 30, 2019 · 13 shares · 1,109 followers View post →
DNA&RNA Universe
@DNA_RNA_Uni · X

Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing" annotated to be more precise and more efficient than CRISPR

Dec 30, 2019 · 29 likes · 13 shares · 39,374 followers View post →
Kursad Turksen
@kursadturksen · X

#CRISPR Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/laYaqRY9Es

Dec 26, 2019 · 231 followers View post →
Brent Segal
@bsegal73 · X

Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/tHi74zhcSA

Dec 8, 2019 · 836 followers View post →
Dr. Eugène
@Matadon_ · X

RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/XmMRAWYrdb

Nov 29, 2019 · 26 shares · 7,524 followers View post →
Paul Mooney
@ptimothymooney · X

Search-and-replace genome editing without double-strand breaks or donor DNA: https://t.co/Q7a7nN9Uw9 https://t.co/Rfz8zLbZml

Nov 25, 2019 · 205 followers View post →
Messi
@MessiCaliber · X

@Sci_Hub @ringo_ring Hello just wanted to ask if there is any specific region why https://t.co/kb5gSnbg3k is not available yet? Papers published before and after it are available already. Love what you guys have done for students/researchers from all over the world. Good Luck.

Nov 22, 2019 · 62 followers View post →
SeqComplete
@SeqComplete · X

#CRISPR/Cas9 #GenomeEditing #geneediting "Search-and-replace genome editing without double-strand breaks or donor DNA", Anzalone et al ... https://t.co/YghZTChCQ6

Nov 17, 2019 · 4,409 followers View post →
TobyLawrence_Lab
@LawrenceTobyLab · X

Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/p72Z2njExh

Nov 13, 2019 · 1 like · 601 followers View post →
BioCel UPO
@BioCelUPO · X

Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/ccJDPLWjWm

Nov 11, 2019 · 217 followers View post →
karlysindy
@karlysindy · X

Pretty interesting! Prime editing makes a single strand cut at a DNA location(instead of a double strand break which is more prone to errors when repaired). Then extends that cut with the edited DNA sequence. DOI 10.1038/s41586-019-1711-4 https://t.co/TnH7UNy1yU

Nov 8, 2019 · 154 followers View post →
Satoshi TAKAHASHI
@s_s_satoc · X

Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/ppBBumnPff 元論文

Nov 4, 2019 · 137 followers View post →
Tom Silver
@TomSilver39 · X

Good article: Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/ChJePN0G6D

Nov 4, 2019 · 9,712 followers View post →
ryo694
@ryo694 · X

Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/UAR89EHbkd

Nov 4, 2019 · 1,389 followers View post →
Researchphilia
@researchphilia · X

Oct 31, 2019 · 483 followers View post →
Researchphilia
@researchphilia · X

Oct 31, 2019 · 483 followers View post →
Javier Forment @javijevi.bsky.social
@javijevi · X

RT @jbrumos7: This is a game changer!!! Search-and-replace genome editing without double-strand breaks or donor DNA. Prime editing rewrites…

Oct 31, 2019 · 6 shares · 1,047 followers View post →
Researchphilia
@researchphilia · X

Oct 31, 2019 · 483 followers View post →
vegan omen
@theforthkingdom · X

RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…

Oct 30, 2019 · 48 shares · 42 followers View post →
shecanhazpdf
@hecanhazpdf · X

RT @RhazyelSavant: #icanhazpdf Anzalone AV, Liu DR. Nature 2019. doi: 10.1038/s41586-019-1711-4 excelsior.scitechs@gmail.com

Oct 30, 2019 · 1 share · 999 followers View post →
shecanhazpdf
@hecanhazpdf · X

RT @Carlos34334631: #icanhazpdf Anzalone AV, Liu DR. Nature 2019. doi: 10.1038/s41586-019-1711-4 charlesman1@gmail.com

Oct 30, 2019 · 1 share · 999 followers View post →
Global Plant Council
@GlobalPlantGPC · X

RT @NewsSEFV: Nice summary of the @nature paper entitled "Search-and-replace genome editing without double-strand breaks or donor DNA" by @…

Oct 30, 2019 · 3 shares · 18,425 followers View post →
Fabrice Leclerc
@rnomics · X

Top #tweeted #RNA list story: Search-and-replace genome editing without double-strand breaks or donor DNA. - PubMed - NCBI https://t.co/2CrrmfGx78, see more https://t.co/QRe3vIMZc3

Oct 29, 2019 · 2,760 followers View post →
Oligonucleotide Therapeutics Society
@OTSociety · X

Search-and-replace genome editing without double-strand breaks or donor DNA @liugroup #GeneEditing #CRISPR $PRQR $NTLA $CRSP $SGMO $EDIT @ExonicsTx #exonics #BaseEditing @GaetanBurgio @CRISPR_papers https://t.co/GiF0Dk0Pw5 https://t.co/ns2wV1bcwY

Oct 29, 2019 · 1 like · 4,093 followers View post →
Researchphilia
@researchphilia · X

Oct 28, 2019 · 483 followers View post →
Jaswinder Singh
@JaswinderMcGill · X

RT @gefses_create: "Search-and-replace genome editing without double-strand breaks or donor DNA" @nresearchnews https://t.co/jTxGEqLAoE

Oct 28, 2019 · 1 share · 648 followers View post →
Kursad Turksen
@kursadturksen · X

#STEMCELL #CRISPR Search-and-replace genome editing without double-strand breaks or donor DNA. - PubMed - NCBI https://t.co/lcCCWduM1B

Oct 28, 2019 · 231 followers View post →
Researchphilia
@researchphilia · X

Oct 28, 2019 · 483 followers View post →
Esteban Escobar
@EE_Escobar · X

RT @MoritzNowack: This deserves a WOW! Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/mC…

Oct 28, 2019 · 11 shares · 168 followers View post →
Researchphilia
@researchphilia · X

Oct 28, 2019 · 483 followers View post →
Tessa Alexanian
@tessafyi · X

RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…

Oct 27, 2019 · 48 shares · 2,162 followers View post →
Islamic Bioethics (Mohammed Ghaly)
@IBioethics · X

Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/BPhJjcrqjK

Oct 27, 2019 · 1,228 followers View post →
James V. Kohl
@microRNApro · X

https://t.co/gLqCVeAHMA Amino acid coevolution induces an evolutionary Stokes shift (2012) is now misrepresented as Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/KnxfOjXjCp reported as https://t.co/pnFM5gj7az New ‘prime’ genome editor...

Oct 27, 2019 · 1 like · 2,568 followers View post →
Dye Year
@SpecterMolecule · X

Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/Gygspy6rp8 - via Researcher https://t.co/n0BEsH2s9v (@ResearcherApp)

Oct 26, 2019 · 37 followers View post →
Papa Sobrinha I
@hugovieiradm · X

Esse aqui: https://t.co/tTPAOsJy1K

Oct 26, 2019 · 1 like · 240 followers View post →
Researchphilia
@researchphilia · X

Oct 26, 2019 · 483 followers View post →
Jay
@jckellyinc · X

RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…

Oct 26, 2019 · 48 shares · 19 followers View post →
KathMorrow90
@KathMorrow90 · X

RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…

Oct 26, 2019 · 48 shares · 2,320 followers View post →
Humanism make Sociallize Active of the poetry man
@Realblack212 · X

Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/3rrduOnn5w - via Researcher https://t.co/exIdaC4qGK (@ResearcherApp)

Oct 25, 2019 · 18,195 followers View post →
繝懊う繝ウ蠎鈴聞
@thin_age · X

Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/HESclNoQVm

Oct 25, 2019 · 187 followers View post →
Matt Warner
@sakhalinsk_matt · X

RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…

Oct 25, 2019 · 48 shares · 233 followers View post →
Chalmers
@nano_chalmers · X

Moving away from classic Cas9-RNPs into the new CRISPR based editing technique: Prime editing. Correcting single point mutation efficiently! Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/BM5KXtV0WQ

Oct 25, 2019 · 381 followers View post →
John Morgan
@JohnDPMorgan · X

RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…

Oct 25, 2019 · 48 shares · 2,292 followers View post →
Abhinav Jain
@Abhinav_Jain_19 · X

Search-and-replace genome editing without double-strand breaks or donor DNA #CRISPR https://t.co/X0qSXLFei8

Oct 25, 2019 · 603 followers View post →
Researchphilia
@researchphilia · X

Oct 25, 2019 · 483 followers View post →
Paris Roidos
@PRoidos · X

RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/EFO5ONmEnR https:/…

Oct 25, 2019 · 31 shares · 25 followers View post →
Luís
@luisvalesilva · X

Prime editing: Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/NdD2tBe8wI

Oct 25, 2019 · 99 followers View post →
Zeek YayGurr
@LilBouj1 · X

RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…

Oct 24, 2019 · 48 shares · 22 followers View post →
Bernard Thienpont
@bernthie · X

RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/XmMRAWYrdb

Oct 24, 2019 · 26 shares · 461 followers View post →
Louella Vasquez
@VasquezLouella · X

RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/XmMRAWYrdb

Oct 24, 2019 · 26 shares · 42 followers View post →
Louella Vasquez
@VasquezLouella · X

RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/EFO5ONmEnR https:/…

Oct 24, 2019 · 31 shares · 42 followers View post →
Essi Laajala
@EssiLaajala · X

RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/EFO5ONmEnR https:/…

Oct 24, 2019 · 31 shares · 70 followers View post →
IBMCP - Instituto de Biología Molecular y Celular
@IBMCP · X

RT @jbrumos7: This is a game changer!!! Search-and-replace genome editing without double-strand breaks or donor DNA. Prime editing rewrites…

Oct 24, 2019 · 6 shares · 7,234 followers View post →
Daniel Martinez
@danielmartinezf · X

RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…

Oct 24, 2019 · 48 shares · 475 followers View post →
Tracy
@TracyHasselhoff · X

Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/xcGrzvBf5f

Oct 24, 2019 · 219 followers View post →
Dmitrii (Dima) Smirnov
@SmirnovDDD · X

RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/EFO5ONmEnR https:/…

Oct 24, 2019 · 31 shares · 176 followers View post →
Keefe Chan
@KeefeChan1 · X

RT @LevKats: Really incredible stuff, going to make a lot of things possible! Can’t wait to start playing with this. Search-and-replace gen…

Oct 24, 2019 · 2 shares · 144 followers View post →
Donato Capitella
@dcapitella · X

RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…

Oct 24, 2019 · 48 shares · 537 followers View post →
John Tikas
@johntikas · X

RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/EFO5ONmEnR https:/…

Oct 23, 2019 · 31 shares · 91 followers View post →
CCA
@canalesaguirre · X

RT @pandolfatto: Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/F76ntrjxRJ

Oct 23, 2019 · 6 shares · 1,154 followers View post →
Yi-Jyun Luo
@YJ_Luo · X

RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…

Oct 23, 2019 · 48 shares · 1,081 followers View post →
Suhnylla Kler
@SuhnyllaKler · X

RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…

Oct 23, 2019 · 48 shares · 1,557 followers View post →
Peter Mac Research
@PeterMacRes · X

RT @LevKats: Really incredible stuff, going to make a lot of things possible! Can’t wait to start playing with this. Search-and-replace gen…

Oct 23, 2019 · 2 shares · 3,849 followers View post →
Dain Bolling [Italian Sitcom Aficionado]
@BollingDain · X

RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…

Oct 23, 2019 · 48 shares · 209 followers View post →
Lev Kats
@LevKats · X

Really incredible stuff, going to make a lot of things possible! Can’t wait to start playing with this. Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/fjAAWrtedC

Oct 23, 2019 · 6 likes · 2 shares · 407 followers View post →
Julia B.
@JuliaB_fitness · X

RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…

Oct 23, 2019 · 48 shares · 2,272 followers View post →
Evil twin
@evilttwinn · X

Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/EFngFaTrCn

Oct 23, 2019 · 2,273 followers View post →
Angel Rene Del Valle Echevarria
@DrAngelRene · X

RT @jbrumos7: This is a game changer!!! Search-and-replace genome editing without double-strand breaks or donor DNA. Prime editing rewrites…

Oct 23, 2019 · 6 shares · 420 followers View post →
Harri Ohra-aho
@Ohra_aho · X

Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/NkRuMW3kiQ

Oct 23, 2019 · 1 like · 40,826 followers View post →
GEFSES_CREATE
@gefses_create · X

"Search-and-replace genome editing without double-strand breaks or donor DNA" @nresearchnews https://t.co/jTxGEqLAoE

Oct 23, 2019 · 2 likes · 1 share · 180 followers View post →
Dj Bambah-Mukku
@GraveNeurosis · X

RT @pandolfatto: Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/F76ntrjxRJ

Oct 23, 2019 · 6 shares · 549 followers View post →
David
@GJDavid_ · X

RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…

Oct 23, 2019 · 48 shares · 13 followers View post →
PIER MARIA FORNASARI
@PierFornasari · X

Search-and-replace genome editing without double-strand breaks or donor DNA.This new technique is called the “prime editing” and is being developed and modified by a team at the @broadinstitute of MIT and @FMHarvard. https://t.co/7m4EwDhFlt https://t.co/uudY1gPCdx

Oct 23, 2019 · 326 followers View post →
R.S
@RhazyelSavant · X

#icanhazpdf Anzalone AV, Liu DR. Nature 2019. doi: 10.1038/s41586-019-1711-4 excelsior.scitechs@gmail.com

Oct 23, 2019 · 1 share · 7 followers View post →
Rigel Salinas
@Rigelitactica · X

RT @hendersi: Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/JM7hQVuzit Pretty clever 'prime edit…

Oct 23, 2019 · 6 shares · 376 followers View post →
Bill Boz
@bill_boz · X

RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…

Oct 23, 2019 · 48 shares · 815 followers View post →
salazar.camilo
@salazarbiol · X

RT @pandolfatto: Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/F76ntrjxRJ

Oct 23, 2019 · 6 shares · 861 followers View post →
Khizar Razzaq
@Mkhizar012 · X

RT @DukeHeitman: A new gene editing tool could make CRISPR more precise https://t.co/PTJ8TPhQS9 https://t.co/xCJ40dtVYm Research article:…

Oct 23, 2019 · 10 shares · 249 followers View post →
ねこのひげ
@KumisKuting · X

RT @noriji0: 話題になってるこれ Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/eigqdBTfNq #nor論文 見た。結果のインパ…

Oct 23, 2019 · 5 shares · 218 followers View post →
divetoinfinity@創薬研究
@divetoinfinity · X

RT @noriji0: 話題になってるこれ Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/eigqdBTfNq #nor論文 見た。結果のインパ…

Oct 23, 2019 · 5 shares · 4,152 followers View post →
Andrew Kiggundu
@andrewkiggundu · X

There we go...Prime DNA editing

Oct 23, 2019 · 897 followers View post →
Pierre Devaux
@PDevaux_FD · X

Off-target effects i.e. extra cuts in undesirable sections of DNA remain a critical issue in genome-editing using CRISPR-Cas9. The new prime editing cuts just one strand of DNA, leaving the other intact and is more precise and accurate. See doi:10.1038/s41586-019-1711-4

Oct 23, 2019 · 1,655 followers View post →
myrtani
@myrtani · X

Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/234vgDrsTk

Oct 23, 2019 · 1 like · 1,973 followers View post →
myrtani
@myrtani · X

This is a truly genetic engineering revolution. CRISPR-PRIME is here. https://t.co/234vgDrsTk

Oct 23, 2019 · 1 like · 1,973 followers View post →
Suchetha Wijenayake
@suchetha · X

search & replace on DNA... this fills me with glee and fear... we are living in sci-fi people... whether it's a dystopia or a utopia depends on our choices "People generally react to any new situation in one of four ways: Aha!...... https://t.co/ph58F5bkH4

Oct 22, 2019 · 354 followers View post →
Virtual Coach
@virtualencoach · X

Cool! https://t.co/eaUAdqKX5w

Oct 22, 2019 · 5,805 followers View post →
David Rosenthal (@davidros.bsky.social)
@davidr11 · X

Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/MaVUD1nq1z

Oct 22, 2019 · 3,027 followers View post →
Peter Ravn Rasmussen
@peter_ravn · X

Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/fEChMl9Kb4

Oct 22, 2019 · 442 followers View post →
Steve Romine
@RhabbKnotte · X

Hey Aldous Huxley... now this is a brave new world! https://t.co/YTo7iXmgQN

Oct 22, 2019 · 536 followers View post →
Gökçe Mehmet AY
@kisalar · X

Gen düzenlemede bir eşik daha aşıldı. Artık hızlı gen düzenleme çağına girdik. https://t.co/mJ4GK6gWen

Oct 22, 2019 · 986 followers View post →
Secret Jody
@ControllingJody · X

Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/VNip7bqISz

Oct 22, 2019 · 362 followers View post →
August
@august1970wealt · X

https://t.co/z1Nwpjv7g1

Oct 22, 2019 · 66 followers View post →