Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing" annotated to be more precise and more efficient than CRISPR
Search-and-replace genome editing without double-strand breaks or donor DNA.
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Oct 2019 – May 2025Where it's discussed
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News270 articles
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X / Twitter119 posts
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Blogs45 articles
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Facebook35 posts
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Reddit6 posts
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YouTube2 videos
AI synopsis
What people are saying
Many discussions highlight the innovative aspects of prime editing, such as the ability to make single-strand cuts while reducing unintended errors. Phrases like 'game changer' and 'genetic engineering revolution' are used to convey excitement and the potential for significant advancements in treating genetic diseases. The tone is predominantly optimistic, illustrating both a fascination with the technology and an acknowledgment of the responsibilities it entails.
A majority of discussions express strong support for the methodologies presented in the publication, highlighting its advantages over previous gene editing techniques.
Posts reflect high levels of curiosity, indicating a strong desire to learn about and explore prime editing.
Many contributors discuss the specifics of prime editing and its applications in detail, suggesting a deeper understanding and contemplation of the material.
The community perceives this advancement as having a significant impact on the field of genetic engineering and healthcare.
Abstract in brief
- Prime editing is a precise genome editing technique that allows for the direct insertion of new genetic information at specific DNA sites without causing double-strand breaks or using donor DNA templates.
- The method has successfully conducted over 175 edits in human cells, including various mutations and corrections for diseases like sickle cell and Tay-Sachs, while maintaining a low level of byproducts.
- Compared to traditional methods like homology-directed repair and base editing, prime editing offers higher efficiency, fewer unintended changes, and has the potential to address a significant number of genetic variants linked to human diseases.
Top posts
Most liked on X and BlueskyExactly 3 years ago, the seminal Prime Editing paper was published in Nature. Yesterday, Prime Medicine successfully completed its IPO.
#SMA Ekibimizden @cemrecaninci @ozumkilic @haleahsenbabar "Search-and-Replace Genome Editing Without Double-Strand Breaks or Donor DNA" isimli sunumlarını gerçekleştirdi. Araştırmacılarımıza deneylerinde başarılar dileriz. #TRGENMER @uskudaruni @CihanTastan_PhD https://t.co/gBt61st5rq
Really incredible stuff, going to make a lot of things possible! Can’t wait to start playing with this. Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/fjAAWrtedC
@Biotech2k1 @toby_crooks @kernytsky Anzalone et al https://t.co/CjDJHWxYnI
"Search-and-replace genome editing without double-strand breaks or donor DNA" @nresearchnews https://t.co/jTxGEqLAoE
All mentions
Precision Genome Editing with Prime Editing Techniques
This presentation describes precise genome editing techniques, including Prime Editing, which allows for direct genetic insertion without double-strand breaks. This new method shows higher efficiency and fewer…
CRISPR Therapy for CPS1 Deficiency: A Breakthrough Case Study
A baby treated with CRISPR for CPS1 deficiency shows significant improvement. This video explores the innovative gene-editing therapy developed to address severe genetic disorders, highlighting its impact and the…
Key paper: Prime editing - search and replace genome editing without double-strand breaks or donor DNA. https://t.co/4UMvYVfGHo Prime editing expands the scope of genome editing, and in principle can correct up to 89% of known genetic variants associated with human diseases.
Search-and-replace genome editing without double-strand breaks or donor DNA #PrimeEditing https://t.co/e5YRAlOXR1
Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/q4zvjPhMv4
RT @trgenmer: #SMA Ekibimizden @cemrecaninci @ozumkilic @haleahsenbabar "Search-and-Replace Genome Editing Without Double-Strand Breaks or…
RT @trgenmer: #SMA Ekibimizden @cemrecaninci @ozumkilic @haleahsenbabar "Search-and-Replace Genome Editing Without Double-Strand Breaks or…
RT @trgenmer: #SMA Ekibimizden @cemrecaninci @ozumkilic @haleahsenbabar "Search-and-Replace Genome Editing Without Double-Strand Breaks or…
RT @trgenmer: #SMA Ekibimizden @cemrecaninci @ozumkilic @haleahsenbabar "Search-and-Replace Genome Editing Without Double-Strand Breaks or…
#SMA Ekibimizden @cemrecaninci @ozumkilic @haleahsenbabar "Search-and-Replace Genome Editing Without Double-Strand Breaks or Donor DNA" isimli sunumlarını gerçekleştirdi. Araştırmacılarımıza deneylerinde başarılar dileriz. #TRGENMER @uskudaruni @CihanTastan_PhD https://t.co/gBt61st5rq
RT @zhaoweiasu: Exactly 3 years ago, the seminal Prime Editing paper was published in Nature. Yesterday, Prime Medicine successfully comp…
RT @zhaoweiasu: Exactly 3 years ago, the seminal Prime Editing paper was published in Nature. Yesterday, Prime Medicine successfully comp…
RT @zhaoweiasu: Exactly 3 years ago, the seminal Prime Editing paper was published in Nature. Yesterday, Prime Medicine successfully comp…
Exactly 3 years ago, the seminal Prime Editing paper was published in Nature. Yesterday, Prime Medicine successfully completed its IPO.
Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/h3zsKKy9YR
@Biotech2k1 @toby_crooks @kernytsky Anzalone et al https://t.co/CjDJHWxYnI
RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/EFO5ONmEnR https:/…
RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…
RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…
RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…
RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…
RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…
RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…
RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…
RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…
RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…
RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…
RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…
RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…
RT @DNA_RNA_Uni: Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing…
Search-and-replace genome editing without double-strand breaks or donor DNA (2019) https://t.co/iSbpF9AE3y "Prime editing" annotated to be more precise and more efficient than CRISPR
#CRISPR Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/laYaqRY9Es
Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/tHi74zhcSA
RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/XmMRAWYrdb
Search-and-replace genome editing without double-strand breaks or donor DNA: https://t.co/Q7a7nN9Uw9 https://t.co/Rfz8zLbZml
@Sci_Hub @ringo_ring Hello just wanted to ask if there is any specific region why https://t.co/kb5gSnbg3k is not available yet? Papers published before and after it are available already. Love what you guys have done for students/researchers from all over the world. Good Luck.
#CRISPR/Cas9 #GenomeEditing #geneediting "Search-and-replace genome editing without double-strand breaks or donor DNA", Anzalone et al ... https://t.co/YghZTChCQ6
Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/p72Z2njExh
Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/ccJDPLWjWm
Pretty interesting! Prime editing makes a single strand cut at a DNA location(instead of a double strand break which is more prone to errors when repaired). Then extends that cut with the edited DNA sequence. DOI 10.1038/s41586-019-1711-4 https://t.co/TnH7UNy1yU
Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/ppBBumnPff 元論文
Good article: Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/ChJePN0G6D
Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/UAR89EHbkd
RT @jbrumos7: This is a game changer!!! Search-and-replace genome editing without double-strand breaks or donor DNA. Prime editing rewrites…
RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…
RT @RhazyelSavant: #icanhazpdf Anzalone AV, Liu DR. Nature 2019. doi: 10.1038/s41586-019-1711-4 excelsior.scitechs@gmail.com
RT @Carlos34334631: #icanhazpdf Anzalone AV, Liu DR. Nature 2019. doi: 10.1038/s41586-019-1711-4 charlesman1@gmail.com
RT @NewsSEFV: Nice summary of the @nature paper entitled "Search-and-replace genome editing without double-strand breaks or donor DNA" by @…
Top #tweeted #RNA list story: Search-and-replace genome editing without double-strand breaks or donor DNA. - PubMed - NCBI https://t.co/2CrrmfGx78, see more https://t.co/QRe3vIMZc3
Search-and-replace genome editing without double-strand breaks or donor DNA @liugroup #GeneEditing #CRISPR $PRQR $NTLA $CRSP $SGMO $EDIT @ExonicsTx #exonics #BaseEditing @GaetanBurgio @CRISPR_papers https://t.co/GiF0Dk0Pw5 https://t.co/ns2wV1bcwY
RT @gefses_create: "Search-and-replace genome editing without double-strand breaks or donor DNA" @nresearchnews https://t.co/jTxGEqLAoE
#STEMCELL #CRISPR Search-and-replace genome editing without double-strand breaks or donor DNA. - PubMed - NCBI https://t.co/lcCCWduM1B
RT @MoritzNowack: This deserves a WOW! Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/mC…
RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…
Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/BPhJjcrqjK
https://t.co/gLqCVeAHMA Amino acid coevolution induces an evolutionary Stokes shift (2012) is now misrepresented as Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/KnxfOjXjCp reported as https://t.co/pnFM5gj7az New ‘prime’ genome editor...
Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/Gygspy6rp8 - via Researcher https://t.co/n0BEsH2s9v (@ResearcherApp)
Esse aqui: https://t.co/tTPAOsJy1K
RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…
RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…
Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/3rrduOnn5w - via Researcher https://t.co/exIdaC4qGK (@ResearcherApp)
Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/HESclNoQVm
RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…
Moving away from classic Cas9-RNPs into the new CRISPR based editing technique: Prime editing. Correcting single point mutation efficiently! Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/BM5KXtV0WQ
RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…
Search-and-replace genome editing without double-strand breaks or donor DNA #CRISPR https://t.co/X0qSXLFei8
RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/EFO5ONmEnR https:/…
Prime editing: Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/NdD2tBe8wI
RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…
RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/XmMRAWYrdb
RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/XmMRAWYrdb
RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/EFO5ONmEnR https:/…
RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/EFO5ONmEnR https:/…
RT @jbrumos7: This is a game changer!!! Search-and-replace genome editing without double-strand breaks or donor DNA. Prime editing rewrites…
RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…
Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/xcGrzvBf5f
RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/EFO5ONmEnR https:/…
RT @LevKats: Really incredible stuff, going to make a lot of things possible! Can’t wait to start playing with this. Search-and-replace gen…
RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…
RT @NatureGenet: Online @nature Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/EFO5ONmEnR https:/…
RT @pandolfatto: Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/F76ntrjxRJ
RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…
RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…
RT @LevKats: Really incredible stuff, going to make a lot of things possible! Can’t wait to start playing with this. Search-and-replace gen…
RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…
Really incredible stuff, going to make a lot of things possible! Can’t wait to start playing with this. Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/fjAAWrtedC
RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…
Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/EFngFaTrCn
RT @jbrumos7: This is a game changer!!! Search-and-replace genome editing without double-strand breaks or donor DNA. Prime editing rewrites…
Search-and-replace genome editing without double-strand breaks or donor DNA | Nature https://t.co/NkRuMW3kiQ
"Search-and-replace genome editing without double-strand breaks or donor DNA" @nresearchnews https://t.co/jTxGEqLAoE
RT @pandolfatto: Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/F76ntrjxRJ
RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…
Search-and-replace genome editing without double-strand breaks or donor DNA.This new technique is called the “prime editing” and is being developed and modified by a team at the @broadinstitute of MIT and @FMHarvard. https://t.co/7m4EwDhFlt https://t.co/uudY1gPCdx
#icanhazpdf Anzalone AV, Liu DR. Nature 2019. doi: 10.1038/s41586-019-1711-4 excelsior.scitechs@gmail.com
RT @hendersi: Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/JM7hQVuzit Pretty clever 'prime edit…
RT @davidasinclair: David Liu does it again. VIP - very important paper. Why? A concern has been that CRISPR induces DNA breaks, halts the…
RT @pandolfatto: Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/F76ntrjxRJ
RT @DukeHeitman: A new gene editing tool could make CRISPR more precise https://t.co/PTJ8TPhQS9 https://t.co/xCJ40dtVYm Research article:…
RT @noriji0: 話題になってるこれ Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/eigqdBTfNq #nor論文 見た。結果のインパ…
RT @noriji0: 話題になってるこれ Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/eigqdBTfNq #nor論文 見た。結果のインパ…
There we go...Prime DNA editing
Off-target effects i.e. extra cuts in undesirable sections of DNA remain a critical issue in genome-editing using CRISPR-Cas9. The new prime editing cuts just one strand of DNA, leaving the other intact and is more precise and accurate. See doi:10.1038/s41586-019-1711-4
Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/234vgDrsTk
This is a truly genetic engineering revolution. CRISPR-PRIME is here. https://t.co/234vgDrsTk
search & replace on DNA... this fills me with glee and fear... we are living in sci-fi people... whether it's a dystopia or a utopia depends on our choices "People generally react to any new situation in one of four ways: Aha!...... https://t.co/ph58F5bkH4
Cool! https://t.co/eaUAdqKX5w
Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/MaVUD1nq1z
Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/fEChMl9Kb4
Hey Aldous Huxley... now this is a brave new world! https://t.co/YTo7iXmgQN
Gen düzenlemede bir eşik daha aşıldı. Artık hızlı gen düzenleme çağına girdik. https://t.co/mJ4GK6gWen
Search-and-replace genome editing without double-strand breaks or donor DNA https://t.co/VNip7bqISz
https://t.co/z1Nwpjv7g1