Publications by authors named "Alexander Broadhead"

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The LPAR1 antagonist, PIPE-791 produces antifibrotic effects in models of lung fibrosis.
Michael Poon, Kym Lorrain, Alexander Broadhead, Karin Stebbins, Didier Bagnol

Respir Res· August 2025

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Novel tertiary diarylethylamines as functionally selective agonists of the kappa opioid receptor.
Thomas O Schrader, Kym I Lorrain, Matthew R Nelli, Yu Xue, Yong Chen, Alexander Broadhead

Bioorg Med Chem Lett· May 2025

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Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis.
Michael M Poon, Kym I Lorrain, Karin J Stebbins, Geraldine C Edu, Alexander R Broadhead

Proc Natl Acad Sci U S A· August 2024

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Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis.
Michael M Poon, Kym I Lorrain, Karin J Stebbins, Geraldine C Edu, Alexander R Broadhead

Sci Rep· May 2024

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Identification and In Vivo Evaluation of Myelination Agent PIPE-3297, a Selective Kappa Opioid Receptor Agonist Devoid of β-Arrestin-2 Recruitment Efficacy.
Thomas O Schrader, Kym I Lorrain, Didier Bagnol, Geraldine C Edu, Alexander Broadhead

ACS Chem Neurosci· February 2024

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Discovery of PIPE-359, a Brain-Penetrant, Selective M Receptor Antagonist with Robust Efficacy in Murine MOG-EAE.
Thomas O Schrader, Yifeng Xiong, Ariana O Lorenzana, Alexander Broadhead, Karin J Stebbins

ACS Med Chem Lett· January 2021

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DP2 (CRTh2) antagonism reduces ocular inflammation induced by allergen challenge and respiratory syncytial virus.
Karin J Stebbins, Alexander R Broadhead, Alla Musiyenko, Sailen Barik, Jill M Scott

Int Arch Allergy Immunol· May 2012

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