Publications by authors named "Alexander Cobitz"

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Linerixibat in patients with primary biliary cholangitis and cholestatic pruritus (GLISTEN): a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial.
Gideon M Hirschfield, Christopher L Bowlus, David E J Jones, Andreas E Kremer, Marlyn J Mayo, Alexander R Cobitz

Lancet Gastroenterol Hepatol· January 2026

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Analysis of on-treatment cancer safety events with daprodustat versus conventional erythropoiesis-stimulating agents-post hoc analyses of the ASCEND-ND and ASCEND-D trials.
Ajay K Singh, Finnian R McCausland, Brian L Claggett, Christoph Wanner, Andrzej Wiecek, Alexander R Cobitz

Nephrol Dial Transplant· July 2023

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Regional Variation of Erythropoiesis-Stimulating Agent Hyporesponsiveness in the Global Daprodustat Dialysis Study (ASCEND-D).
Iain C Macdougall, Amy M Meadowcroft, Allison Blackorby, Borut Cizman, Alexander R Cobitz

Am J Nephrol· June 2023

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The ASCEND-NHQ randomized trial found positive effects of daprodustat on hemoglobin and quality of life in patients with non-dialysis chronic kidney disease.
Kirsten L Johansen, Alexander R Cobitz, Ajay K Singh, Iain C Macdougall, Renato D Lopes

Kidney Int· June 2023

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Safety of daprodustat in patients with anemia of chronic kidney disease: A pooled analysis of phase 3 studies in Japan.
Masaomi Nangaku, Tadao Akizawa, Takashi Nagakubo, Taeko Yonekawa, Toshifumi Kimura, Alexander Cobitz

Ther Apher Dial· December 2022

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The ASCEND-ND trial: study design and participant characteristics.
Vlado Perkovic, Allison Blackorby, Borut Cizman, Kevin Carroll, Alexander R Cobitz

Nephrol Dial Transplant· October 2022

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Three Times Weekly Dosing of Daprodustat versus Conventional Epoetin for Treatment of Anemia in Hemodialysis Patients: ASCEND-TD: A Phase 3 Randomized, Double-Blind, Noninferiority Trial.
Daniel W Coyne, Ajay K Singh, Renato D Lopes, Christine K Bailey, Tara L DiMino, Alexander R Cobitz

Clin J Am Soc Nephrol· September 2022

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Efficacy and Safety of Daprodustat for Treatment of Anemia of Chronic Kidney Disease in Incident Dialysis Patients: A Randomized Clinical Trial.
Ajay K Singh, Borut Cizman, Kevin Carroll, John J V McMurray, Vlado Perkovic, Alexander R Cobitz

JAMA Intern Med· June 2022

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Pharmacokinetics of Daprodustat and Metabolites in Individuals with Normal and Impaired Hepatic Function.
Kelly M Mahar, Bonnie C Shaddinger, Bandi Ramanjineyulu, Susan Andrews, Stephen Caltabiano, Alexander R Cobitz

Clin Pharmacol Drug Dev· May 2022

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Study design and baseline characteristics of patients on dialysis in the ASCEND-D trial.
Ajay K Singh, Allison Blackorby, Borut Cizman, Kevin Carroll, Alexander R Cobitz

Nephrol Dial Transplant· April 2022

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Challenges of Conducting Clinical Trials during the SARS-CoV-2 Pandemic: The ASCEND Global Program Experience.
Kirsten L Johansen, Anjali Acharya, Borut Cizman, Alexander R Cobitz, Ricardo Correa-Rotter

Kidney360· April 2022

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Efficacy and safety of daprodustat in Japanese peritoneal dialysis patients.
Hidetoshi Kanai, Masaomi Nangaku, Reiko Nagai, Nobuhiko Okuda, Kyo Kurata, Alexander Cobitz

Ther Apher Dial· December 2021

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Clinical Pharmacokinetics of Daprodustat: Results of an Absorption, Distribution, and Excretion Study With Intravenous Microtracer and Concomitant Oral Doses for Bioavailability Determination.
Kelly M Mahar, Stephen Caltabiano, Susan Andrews, Bandi Ramanjineyulu, Liangfu Chen, Alexander R Cobitz

Clin Pharmacol Drug Dev· December 2021

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Daprodustat for the Treatment of Anemia in Patients Not Undergoing Dialysis.
Ajay K Singh, Kevin Carroll, John J V McMurray, Scott Solomon, Vivekanand Jha, Alexander R Cobitz

N Engl J Med· December 2021

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Daprodustat Compared with Epoetin Beta Pegol for Anemia in Japanese Patients Not on Dialysis: A 52-Week Randomized Open-Label Phase 3 Trial.
Masaomi Nangaku, Takayuki Hamano, Tadao Akizawa, Yoshiharu Tsubakihara, Reiko Nagai, Alexander R Cobitz

Am J Nephrol· November 2021

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Efficacy and Safety of Daprodustat Compared with Darbepoetin Alfa in Japanese Hemodialysis Patients with Anemia: A Randomized, Double-Blind, Phase 3 Trial.
Tadao Akizawa, Masaomi Nangaku, Taeko Yonekawa, Nobuhiko Okuda, Shinya Kawamatsu, Alexander R Cobitz

Clin J Am Soc Nephrol· August 2020

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A 24-Week Anemia Correction Study of Daprodustat in Japanese Dialysis Patients.
Yoshiharu Tsubakihara, Tadao Akizawa, Masaomi Nangaku, Tomohiro Onoue, Taeko Yonekawa, Alexander Cobitz

Ther Apher Dial· April 2020

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Effect of renal function and dialysis modality on daprodustat and predominant metabolite exposure.
Stephen Caltabiano, Borut Cizman, Olivia Burns, Kelly M Mahar, Brendan M Johnson, Alexander R Cobitz

Clin Kidney J· October 2019

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A randomized, 29-day, dose-ranging, efficacy and safety study of daprodustat, administered three times weekly in patients with anemia on hemodialysis.
Christine K Bailey, Stephen Caltabiano, Alexander R Cobitz, Chun Huang, Kelly M Mahar

BMC Nephrol· October 2019

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Cardiovascular Event Rates Among Hemodialysis Patients Across Geographical Regions-A Snapshot From The Dialysis Outcomes and Practice Patterns Study (DOPPS).
Heide A Stirnadel-Farrant, Angelo Karaboyas, Borut Cizman, Brian A Bieber, Lata Kler, Alexander R Cobitz

Kidney Int Rep· June 2019

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Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants with chronic kidney disease.
Louis Holdstock, Borut Cizman, Amy M Meadowcroft, Nandita Biswas, Brendan M Johnson, Alexander R Cobitz

Clin Kidney J· February 2019

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Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants on hemodialysis.
Amy M Meadowcroft, Borut Cizman, Louis Holdstock, Nandita Biswas, Brendan M Johnson, Alexander R Cobitz

Clin Kidney J· February 2019

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An Exploratory Study of Daprodustat in Erythropoietin-Hyporesponsive Subjects.
Borut Cizman, Andy P Sykes, Gitanjali Paul, Steven Zeig, Alexander R Cobitz

Kidney Int Rep· July 2018

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Anemia and mortality in patients with nondialysis-dependent chronic kidney disease.
Heide A Stirnadel-Farrant, Jiacong Luo, Lata Kler, Borut Cizman, Delyth Jones, Alexander R Cobitz

BMC Nephrol· June 2018

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