Publications by authors named "Alexander Dowell"

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Multi-omic spatial profiling reveals the unique SARS-CoV-2 lung microenvironment and collagen VI as a predictive biomarker in severe COVID-19.
Éanna Fennell, Graham S Taylor, Ciara I Leahy, Aisling M Ross, Gary Reynolds, Alexander C Dowell

Eur Respir J· September 2025

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Evaluating the effects of ivacaftor exposure on small colony variant development and antibiotic tolerance.
Gretchen E Bollar, Kendall M Shaffer, Johnathan D Keith, Ashley M Oden, Alexander E Dowell

JAC Antimicrob Resist· December 2024

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Pharmacokinetic variability of CFTR modulators from standard and alternative regimens.
Natalie R Rose, Ashritha R Chalamalla, Bryan A Garcia, Stefanie Krick, Jonathan Bergeron, Alexander E Dowell

Pulm Pharmacol Ther· September 2024

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Differential distribution of ivacaftor and its metabolites in plasma and human airway epithelia.
Zhongyu Liu, Justin D Anderson, Natalie R Rose, Elizabeth H Baker, Alexander E Dowell

Pulm Pharmacol Ther· September 2024

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Current state of COVID-19 in children: 4 years on.
Annabel A Powell, Alexander C Dowell, Paul Moss, Shamez N Ladhani,

J Infect· May 2024

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CD36 regulates macrophage and endothelial cell activation and multinucleate giant cell formation in anti neutrophil cytoplasm antibody vasculitis.
Xiang Zhang, Catherine King, Alexander Dowell, Paul Moss, Lorraine Harper

Clin Immunol· March 2024

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Nasal mucosal IgA levels against SARS-CoV-2 and seasonal coronaviruses are low in children but boosted by reinfection.
Alexander C Dowell, Gokhan Tut, Jusnara Begum, Rachel Bruton, Christopher Bentley

J Infect· November 2023

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Early evaluation of the safety, reactogenicity, and immune response after a single dose of modified vaccinia Ankara-Bavaria Nordic vaccine against mpox in children: a national outbreak response.
Shamez N Ladhani, Alexander C Dowell, Scott Jones, Bethany Hicks, Cathy Rowe

Lancet Infect Dis· September 2023

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Nucleocapsid-specific antibodies as a correlate of protection against SARS-CoV-2 reinfection in children.
Alexander C Dowell, Dagmar Waiblinger, John Wright, Shamez N Ladhani, Paul Moss

J Infect· September 2023

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Immunological imprinting of humoral immunity to SARS-CoV-2 in children.
Alexander C Dowell, Tara Lancaster, Rachel Bruton, Georgina Ireland, Christopher Bentley

Nat Commun· June 2023

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Association of Spike-Specific T Cells With Relative Protection From Subsequent SARS-CoV-2 Omicron Infection in Young Children.
Alexander C Dowell, Georgina Ireland, Jianmin Zuo, Paul Moss, Shamez Ladhani

JAMA Pediatr· January 2023

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Quantitation of cystic fibrosis triple combination therapy, elexacaftor/tezacaftor/ivacaftor, in human plasma and cellular lysate.
Kevin J Ryan, Jennifer S Guimbellot, Alexander E Dowell, Kedria D Reed-Walker, Corenna D Kerstner-Wood

J Chromatogr B Analyt Technol Biomed Life Sci· December 2022

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COVID-19 vaccines elicit robust cellular immunity and clinical protection in chronic lymphocytic leukemia.
Helen Parry, Rachel Bruton, Thomas Roberts, Graham McIlroy, Sarah Damery, Alexander C Dowell

Cancer Cell· June 2022

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mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273.
Alexander C Dowell, Annabel A Powell, Chris Davis, Sam Scott, Nicola Logan

Front Immunol· June 2022

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Robust SARS-CoV-2-specific and heterologous immune responses in vaccine-naïve residents of long-term care facilities who survive natural infection.
Gokhan Tut, Tara Lancaster, Megan S Butler, Panagiota Sylla, Eliska Spalkova, Alexander C Dowell

Nat Aging· June 2022

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Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection.
Alexander C Dowell, Megan S Butler, Elizabeth Jinks, Gokhan Tut, Tara Lancaster

Nat Immunol· January 2022

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Cytotoxic CD4+ T-cells specific for EBV capsid antigen BORF1 are maintained in long-term latently infected healthy donors.
Alexander C Dowell, Tracey A Haigh, Gordon B Ryan, James E Turner, Heather M Long

PLoS Pathog· December 2021

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Author Correction: Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection.
Jianmin Zuo, Alexander C Dowell, Hayden Pearce, Kriti Verma, Heather M Long

Nat Immunol· July 2021

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Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection.
Jianmin Zuo, Alexander C Dowell, Hayden Pearce, Kriti Verma, Heather M Long

Nat Immunol· May 2021

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PD-1 is imprinted on cytomegalovirus-specific CD4+ T cells and attenuates Th1 cytokine production whilst maintaining cytotoxicity.
Helen M Parry, Alexander C Dowell, Jianmin Zuo, Kriti Verma, Francesca A M Kinsella

PLoS Pathog· March 2021

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PD-L2 Is Constitutively Expressed in Normal and Malignant Urothelium.
Alexander C Dowell, Haydn Munford, Anshita Goel, Naheema S Gordon, Nicholas D James

Front Oncol· February 2021

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BCL-W is dispensable for the sustained survival of select Burkitt lymphoma and diffuse large B-cell lymphoma cell lines.
Sarah T Diepstraten, Catherine Chang, Lin Tai, Jia-Nan Gong, Ping Lan, Alexander C Dowell

Blood Adv· January 2020

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Complete remission of immunochemotherapy-refractory monomorphic post-transplant lymphoproliferative disorder mediated by endogenous T-cell recovery.
Mark J Bishton, Heather M Long, Alexander C Dowell, Benjamin J Meckiff, Catherine Byrne

Leuk Lymphoma· August 2019

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Regulation of S1PR2 by the EBV oncogene LMP1 in aggressive ABC-subtype diffuse large B-cell lymphoma.
Martina Vockerodt, Katerina Vrzalikova, Maha Ibrahim, Eszter Nagy, Sandra Margielewska, Alexander Dowell

J Pathol· June 2019

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Interleukin-17-positive mast cells influence outcomes from BCG for patients with CIS: Data from a comprehensive characterisation of the immune microenvironment of urothelial bladder cancer.
Alexander C Dowell, Ellen Cobby, Kaisheng Wen, Adam J Devall, Vinnie During

PLoS One· October 2017

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