Publications by authors named "Alexander Ewe"

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Nose-to-brain siRNA delivery by PEI/PPI-based nanoparticles reduces α-synuclein expression in a Parkinson's disease mouse model.
Malte Feja, Isabell Drath, Sandra Weiß, Alexander Ewe, Birthe Gericke

Mol Ther Nucleic Acids· September 2025

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Analysis of Polymer/siRNA Nanoparticle Efficacy and Biocompatibility in 3D Air-Liquid Interface Culture Compared to 2D Cell Culture.
Sandra Noske, Martin Krueger, Alexander Ewe, Achim Aigner

Pharmaceutics· March 2025

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The Concentration of Salivary Extracellular Vesicles Is Related to Obesity.
Kristin Röhrborn, Martin Krueger, Mirjam Kalusa, Simone A Fietz, Alexander Ewe

Nutrients· August 2024

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Glucose-oxygen deprivation constrains HMGCR function and Rac1 prenylation and activates the NLRP3 inflammasome in human monocytes.
Nora Raulien, Kathleen Friedrich, Sarah Strobel, Stefanie Raps, Friederike Hecker, Alexander Ewe

Sci Signal· July 2024

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Spray-drying of PEI-/PPI-based nanoparticles for DNA or siRNA delivery.
Sandra Noske, Michael Karimov, Martin Krüger, Bettina Lilli, Alexander Ewe

Eur J Pharm Biopharm· June 2024

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Efficient polymeric nanoparticles for RNAi in macrophage reveal complex effects on polarization markers upon knockdown of STAT3/STAT6.
Maximilian Walther, Robert Jenke, Achim Aigner, Alexander Ewe

Eur J Pharm Biopharm· April 2024

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The effect of novel tyrosine-modified polyethyleneimines on human albumin structure - Thermodynamic and spectroscopic study.
Małgorzata Kubczak, Marika Grodzicka, Sylwia Michlewska, Michael Karimov, Alexander Ewe

Colloids Surf B Biointerfaces· July 2023

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Analysis of polymeric nanoparticle properties for siRNA/DNA delivery in a tumor xenograft tissue slice air-liquid interface model.
Michael Karimov, Marlene Scherer, Heike Franke, Alexander Ewe, Achim Aigner

Biotechnol J· April 2023

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Comparison of tyrosine-modified low molecular weight branched and linear polyethylenimines for siRNA delivery.
Małgorzata Kubczak, Sylwia Michlewska, Michael Karimov, Alexander Ewe, Achim Aigner

Nanotoxicology· February 2023

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Unmodified and tyrosine-modified polyethylenimines as potential carriers for siRNA: Biophysical characterization and toxicity.
Małgorzata Kubczak, Sylwia Michlewska, Michael Karimov, Alexander Ewe, Sandra Noske

Int J Pharm· February 2022

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A new player in the game: treatment with antagomiR-21a-5p significantly attenuates histological and echocardiographic effects of experimental autoimmune myocarditis.
Moritz Mirna, Vera Paar, Albert Topf, Theo Kraus, Karl Sotlar, Alexander Ewe

Cardiovasc Res· January 2022

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Non-viral siRNA transfection of primary mesenchymal stromal cells (MSCs): Assessment of tyrosine-modified PEI and PPI efficacy and biocompatibility.
Sandra Noske, Michael Karimov, Max Hansen, Nathalie Zatula, Alexander Ewe

Int J Pharm· January 2022

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Amphiphilic Anionic Oligomer-Stabilized Calcium Phosphate Nanoparticles with Prospects in siRNA Delivery via Convection-Enhanced Delivery.
Franziska Mitrach, Maximilian Schmid, Magali Toussaint, Sladjana Dukic-Stefanovic, Winnie Deuther-Conrad, Alexander Ewe

Pharmaceutics· January 2022

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Tyrosine-modified linear PEIs for highly efficacious and biocompatible siRNA delivery in vitro and in vivo.
Michael Karimov, Marion Schulz, Tim Kahl, Sandra Noske, Malgorzata Kubczak, Alexander Ewe

Nanomedicine· August 2021

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Targeted RNAi of BIRC5/Survivin Using Antibody-Conjugated Poly(Propylene Imine)-Based Polyplexes Inhibits Growth of PSCA-Positive Tumors.
Willi Jugel, Achim Aigner, Susanne Michen, Alexander Hagstotz, Alexander Ewe

Pharmaceutics· May 2021

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miR24-3p activity after delivery into pancreatic carcinoma cell lines exerts profound tumor-inhibitory effects through distinct pathways of apoptosis and autophagy induction.
Hannes Borchardt, Alexander Ewe, Markus Morawski, Ulrike Weirauch, Achim Aigner

Cancer Lett· April 2021

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The combined disulfide cross-linking and tyrosine-modification of very low molecular weight linear PEI synergistically enhances transfection efficacies and improves biocompatibility.
Michael Karimov, Dietmar Appelhans, Alexander Ewe, Achim Aigner

Eur J Pharm Biopharm· April 2021

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Nanoparticle-complexed antimiRs for inhibiting tumor growth and metastasis in prostate carcinoma and melanoma.
Manfred Kunz, Madeleine Brandl, Animesh Bhattacharya, Lars Nobereit-Siegel, Alexander Ewe

J Nanobiotechnology· November 2020

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Tyrosine-Modification of Polypropylenimine (PPI) and Polyethylenimine (PEI) Strongly Improves Efficacy of siRNA-Mediated Gene Knockdown.
Sandra Noske, Michael Karimov, Achim Aigner, Alexander Ewe

Nanomaterials (Basel)· September 2020

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Synthetic circular miR-21 RNA decoys enhance tumor suppressor expression and impair tumor growth in mice.
Simon Müller, Alice Wedler, Janina Breuer, Markus Glaß, Nadine Bley, Alexander Ewe

NAR Cancer· September 2020

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Extracellular vesicle (ECV)-modified polyethylenimine (PEI) complexes for enhanced siRNA delivery in vitro and in vivo.
Petro Zhupanyn, Alexander Ewe, Thomas Büch, Anastasia Malek, Phil Rademacher

J Control Release· March 2020

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Polymeric Nanoparticles Based on Tyrosine-Modified, Low Molecular Weight Polyethylenimines for siRNA Delivery.
Alexander Ewe, Sandra Noske, Michael Karimov, Achim Aigner

Pharmaceutics· November 2019

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Therapeutic Targeting of Stat3 Using Lipopolyplex Nanoparticle-Formulated siRNA in a Syngeneic Orthotopic Mouse Glioma Model.
Benedikt Linder, Ulrike Weirauch, Alexander Ewe, Anja Uhmann, Volker Seifert

Cancers (Basel)· March 2019

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Influence of nanoparticle-mediated transfection on proliferation of primary immune cells in vitro and in vivo.
Susanne Przybylski, Michaela Gasch, Anne Marschner, Marcus Ebert, Alexander Ewe

PLoS One· September 2017

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Nanoparticles for radiooncology: Mission, vision, challenges.
Leoni A Kunz-Schughart, Anna Dubrovska, Claudia Peitzsch, Alexander Ewe, Achim Aigner

Biomaterials· March 2017

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