Publications by authors named "Alexander Gozman"

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Belzutifan for Advanced Pheochromocytoma or Paraganglioma.
Camilo Jimenez, Mikkel Andreassen, Alice Durand, Sophie Moog, Andrew Hendifar, Alexander Gozman

N Engl J Med· November 2025

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Pembrolizumab in Patients of Chinese Descent with Microsatellite Instability-high/Mismatch Repair Deficient Advanced Solid Tumors: KEYNOTE-158 Final Analysis.
Xiaohua Wu, Yimin Mao, Nong Xu, Yuxian Bai, Dong Wang, Alexander Gozman

Adv Ther· May 2025

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Pembrolizumab in microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) and non-MSI-H/non-dMMR advanced endometrial cancer: Phase 2 KEYNOTE-158 study results.
David M O'Malley, Giovani M Bariani, Philippe A Cassier, Aurelien Marabelle, Aaron R Hansen, Alexander Gozman

Gynecol Oncol· February 2025

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Pembrolizumab in microsatellite-instability-high and mismatch-repair-deficient advanced solid tumors: updated results of the KEYNOTE-158 trial.
Aurelien Marabelle, David M O'Malley, Andrew E Hendifar, Paolo A Ascierto, Daniel Motola-Kuba, Alexander Gozman

Nat Cancer· February 2025

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Prevalence of Homologous Recombination Repair Mutations and Association with Clinical Outcomes in Patients with Solid Tumors: A Study Using the AACR Project GENIE Dataset.
Changxia Shao, Heng Zhou, Cai Chen, Elisha J Dettman, Yixin Ren, Alexander Gozman

Cancers (Basel)· February 2025

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Prevalence of homologous recombination biomarkers in multiple tumor types: an observational study.
Cai Chen, Elisha J Dettman, Wei Zhou, Alexander Gozman, Fan Jin

Future Oncol· October 2024

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Clinical outcomes for previously treated patients with advanced biliary tract cancer: a meta-analysis.
Mayur M Amonkar, Lauren A Abderhalden, Grace E Fox, Andrew M Frederickson, Torkia Grira, Alexander Gozman

Future Oncol· April 2024

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Pembrolizumab in patients from China with microsatellite instability-high/mismatch repair deficient tumors: KEYNOTE-158.
Jianming Xu, Yimin Mao, Nong Xu, Yuxian Bai, Dong Wang, Alexander Gozman

Immunotherapy· March 2024

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Biomarker Testing Journey Among Patients with Advanced Solid Tumors and Treatment Patterns by Homologous Recombination Repair Status: A Clinico-Genomic Database Study.
Changxia Shao, Yixin Ren, Heng Zhou, Liam C Lee, Cai Chen, Alexander Gozman

Adv Ther· February 2024

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Association Between Homologous Recombination Repair Biomarkers and Survival in Patients With Solid Tumors.
Changxia Shao, Yixin Ren, Heng Zhou, Cai Chen, Elisha J Dettman, Alexander Gozman

JCO Precis Oncol· September 2023

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A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species.
Hongliang Zong, Alexander Gozman, Eloisi Caldas-Lopes, Tony Taldone, Eric Sturgill

Cell Rep· December 2015

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Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer.
Anna Rodina, Tony Taldone, Yanlong Kang, Pallav D Patel, John Koren, Alexander Gozman

ACS Chem Biol· August 2014

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Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70.
Yanlong Kang, Tony Taldone, Hardik J Patel, Pallav D Patel, Anna Rodina, Alexander Gozman

J Med Chem· February 2014

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Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70.
Tony Taldone, Yanlong Kang, Hardik J Patel, Maulik R Patel, Pallav D Patel, Alexander Gozman

J Med Chem· February 2014

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Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.
Anna Rodina, Pallav D Patel, Yanlong Kang, Yogita Patel, Imad Baaklini, Alexander Gozman

Chem Biol· December 2013

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Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.
Iwona E Wrona, Alexander Gozman, Tony Taldone, Gabriela Chiosis, James S Panek

J Org Chem· May 2010

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Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.
Eloisi Caldas-Lopes, Leandro Cerchietti, James H Ahn, Cristina C Clement, Ana I Robles, Alexander Gozman

Proc Natl Acad Sci U S A· May 2009

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Targeting Hsp90: small-molecule inhibitors and their clinical development.
Tony Taldone, Alexander Gozman, Ronnie Maharaj, Gabriela Chiosis

Curr Opin Pharmacol· August 2008

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