Publications by authors named "Alexander Hughes"

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Introducing the Paraspinal Muscle Quality (PMQ) Score: A Novel T2 MRI-Based Intensity Parameter for Lean Muscle Assessment in Spine Patients.
Ali E Guven, Kyle Finos, Isaac Nathoo, Paul Köhli, Marco D Burkhard, Alexander P Hughes

Spine (Phila Pa 1976)· February 2026

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Biomarkers for Preoperative Bone Quality Assessment: A Prospective Investigation of Dermal Ultrasound and Advanced Glycation End-products in Lumbar Fusion Patients.
Erika Chiapparelli, Ali E Guven, Quinton Wright, Paul Köhli, Ranqing Lan, Alexander P Hughes

Ultrasound Med Biol· January 2026

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Alcohol Abuse and Collagen Disruption: Effects on Skin Ultrasound Parameters in Lumbar Fusion Patients.
Erika A Chiapparelli, Ali E Guven, Krizia Amoroso, Ranqing Lan, Gisberto Evangelisti, Alexander P Hughes

Spine (Phila Pa 1976)· December 2025

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10-Year trend of lateral lumbar interbody fusion and the impact of 3D-printed titanium in a high-volume academic center.
Marco D Burkhard, Ali E Guven, Anna-Maria Mielke, Paul Köhli, Jan Hambrecht, Alexander P Hughes

Eur Spine J· December 2025

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The Association Between Preoperative Cannabis Use and Anxiety, Pain Scores and Opioid Consumption in Patients Undergoing Spinal Fusion: A Retrospective Cohort Study.
Krizia Amoroso, Erika Chiapparelli, Jiaqi Zhu, Ali E Guven, Jennifer Shue, Alexander P Hughes

Global Spine J· November 2025

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Abdominal aortic calcification is associated with impaired fusion after elective spinal fusion.
Marco D Burkhard, Thomas Caffard, Lukas Schönnagel, Samuel Medina, Ali E Guven, Alexander P Hughes

Spine J· November 2025

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Postoperative Decrease in Volumetric Bone Mineral Density in Patients Undergoing Anterior or Lateral Lumbar Interbody Fusion: Stand-Alone Versus 360° Constructs.
Koki Tsuchiya, Ichiro Okano, Ali E Guven, Erika Chiapparelli, Paul Kohli, Alexander P Hughes

HSS J· November 2025

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Concordance Between Patients' and Surgeons' Expectations of Cervical Spine Surgery.
Carol A Mancuso, Roland Duculan, Frank P Cammisa, Andrew A Sama, Alexander P Hughes

Spine (Phila Pa 1976)· November 2025

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Risk Factors for Postoperative Non-Satisfaction Despite ODI Improvement in Patients Undergoing Elective Lumbar Surgery.
Jan Hambrecht, Paul Köhli, Erika Chiapparelli, Ranqing Lan, Marco D Burkhard, Alexander P Hughes

Spine (Phila Pa 1976)· October 2025

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Cervical Muscle Composition in Degenerative Dropped Head Syndrome: A Propensity Score Matching Study.
Thomas Caffard, Bruno Verna, Lukas Schönnagel, Ali E Guven, Artine Arzani, Alexander P Hughes

Spine (Phila Pa 1976)· October 2025

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Answer to the letter to the editor of J. Deng, et al. concerning "Relationship between posterior paraspinal muscle fat infiltration and early conversion to lumbar spinal fusion following decompression surgery" by Chiapparelli E, et al. (Eur spine J [2025]: doi: 10.1007/s00586-025-09030-5).
Alexander Hughes

Eur Spine J· October 2025

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Beyond the initial impact: a systematic review of post-traumatic bone loss and its mechanisms.
Adibeh Rahmani, Ulrike Weichelt, Denise Jahn, Ellen Otto, Arne Kienzle, Alexander P Hughes

Osteoporos Int· October 2025

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Greater collagen alignment is associated with accumulation of advanced glycation endproducts in iliac trabecular bone in men and women undergoing spine fusion surgery.
Quinton Wright, Erika Chiapparelli, Jennifer Shue, Kobby Adu, Yi Xin Han, Alexander P Hughes

JBMR Plus· September 2025

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Behavioral Intervention to Foster Healthy Lifestyle Physical Activity After Complex Lumbar Surgery: A Randomized Controlled Trial.
Carol A Mancuso, Roland Duculan, Manuela C Lafage, Frank P Cammisa, Andrew A Sama, Alexander P Hughes

J Bone Joint Surg Am· September 2025

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3D-Printed Titanium: Game-Changer for Standalone Lateral Lumbar Interbody Fusion? An Analysis of Risk Factors for Revision Surgery.
Marco D Burkhard, Ali E Guven, Bryce Demopoulos, Simon Ortiz, Torben Stepan, Alexander P Hughes

Global Spine J· September 2025

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Associated Factors for Increased Fat Infiltration in the Erector Spinae in Patients Undergoing Lumbar Surgery for Degenerative Conditions.
Jan Hambrecht, Paul Köhli, Roland Duculan, Ranqing Lan, Erika Chiapparelli, Alexander P Hughes

Spine (Phila Pa 1976)· August 2025

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Relationship between posterior paraspinal muscle fat infiltration and early conversion to lumbar spinal fusion following decompression surgery.
Erika Chiapparelli, Thomas Caffard, Samuel J Medina, Krizia Amoroso, Jiaqi Zhu, Alexander P Hughes

Eur Spine J· July 2025

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Standalone lateral lumbar interbody fusion reduces the risk of adjacent segment surgery.
Marco D Burkhard, Torben Stepan, Charlotte Jones, John Lama, Nicolas Mjaess, Alexander P Hughes

Spine J· July 2025

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Endplate Degeneration and Intervertebral Vacuum Phenomenon Are Positively Correlated: A Retrospective Study in Patients Undergoing Lumbar Fusion Surgery.
Gaston Camino-Willhuber, Lukas Schönnagel, Erika Chiapparelli, Paul Kohli, Krizia Amoroso, Alexander P Hughes

Clin Spine Surg· June 2025

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Association between subaxial paraspinal muscle parameters and cervical vertebral bone quality in preoperative patients.
Artine Arzani, Bruno Verna, Thomas Caffard, Vidushi Tripathi, Erika Chiapparelli, Alexander P Hughes

J Neurosurg Spine· June 2025

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Discovery of Iboga-Derived Ligands for the Sigma‑2 Receptor.
Alexander J Hughes, Julie A Talbert, Steven D Townsend

ACS Bio Med Chem Au· June 2025

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Is Intraoperative Neuromonitoring with SSEPs and EMG Predictable for Postoperative Neurologic Deficit in Posterior Lumbar Fusion Surgery? A Retrospective Cohort Analysis.
Marco D Burkhard, Gisberto Evangelisti, Franziska C S Altorfer, Philip K Paschal, Chukwuebuka C Achebe, Alexander P Hughes

Global Spine J· May 2025

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Undetected low bone mineral density in patients undergoing lumbar fusion surgery-prevalence and risk factors.
Paul C Köhli, Jan Hambrecht, Jiaqi Zhu, Erika Chiapparelli, Lukas Schönnagel, Alexander P Hughes

N Am Spine Soc J· March 2025

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Disrupting Substance Use Disorder: The Chemistry of Iboga Alkaloids.
Alexander J Hughes, Charles R Hamelink, Steven D Townsend

European J Org Chem· September 2024

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Total Synthesis of Tabernanthine and Ibogaline: Rapid Access to Nosyl Tryptamines.
Alexander J Hughes, Steven D Townsend

European J Org Chem· August 2024

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