Publications by authors named "Alexander Katchman"

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De novo design of a peptide modulator to reverse sodium channel dysfunction linked to cardiac arrhythmias and epilepsy.
Ryan Mahling, Bence Hegyi, Erin R Cullen, Timothy M Cho, Aaron R Rodriques, Alexander N Katchman

Cell· October 2025

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Augmented Cardiac Inotropy by Phosphodiesterase Inhibition Requires Phosphorylation of Rad and Increased Calcium Current.
Alexander N Katchman, Sergey I Zakharov, Michael S Bohnen, Alejandro Sanchez Jimenez, Jared S Kushner

Circulation· May 2024

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A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels.
Arianne Papa, Pedro J Del Rivero Morfin, Bi-Xing Chen, Lin Yang, Alexander N Katchman

J Clin Invest· January 2024

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Rad regulation of Ca1.2 channels controls cardiac fight-or-flight response.
Arianne Papa, Sergey I Zakharov, Alexander N Katchman, Jared S Kushner, Bi-Xing Chen

Nat Cardiovasc Res· November 2022

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Attenuating persistent sodium current-induced atrial myopathy and fibrillation by preventing mitochondrial oxidative stress.
Uma Mahesh R Avula, Haikel Dridi, Bi-Xing Chen, Qi Yuan, Alexander N Katchman

JCI Insight· October 2021

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Adrenergic Ca1.2 Activation via Rad Phosphorylation Converges at α I-II Loop.
Arianne Papa, Jared Kushner, Jessica A Hennessey, Alexander N Katchman, Sergey I Zakharov

Circ Res· January 2021

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Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels.
Jeffrey Abrams, Daniel Roybal, Nourdine Chakouri, Alexander N Katchman, Richard Weinberg

JCI Insight· October 2020

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Mechanism of adrenergic Ca1.2 stimulation revealed by proximity proteomics.
Guoxia Liu, Arianne Papa, Alexander N Katchman, Sergey I Zakharov, Daniel Roybal

Nature· January 2020

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Heterogeneity of the action potential duration is required for sustained atrial fibrillation.
Uma Mahesh R Avula, Jeffrey Abrams, Alexander Katchman, Sergey Zakharov, Sergey Mironov

JCI Insight· April 2019

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Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking.
Lin Yang, Alexander Katchman, Jared Kushner, Alexander Kushnir, Sergey I Zakharov

J Clin Invest· February 2019

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Intact calcium signaling in adrenergic-deficient embryonic mouse hearts.
Jessica N Peoples, David G Taylor, Alexander N Katchman, Steven N Ebert

Biochem Biophys Res Commun· January 2018

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Proteolytic cleavage and PKA phosphorylation of α subunit are not required for adrenergic regulation of Ca1.2 in the heart.
Alexander Katchman, Lin Yang, Sergey I Zakharov, Jared Kushner, Jeffrey Abrams

Proc Natl Acad Sci U S A· August 2017

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Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice.
Elaine Wan, Jeffrey Abrams, Richard L Weinberg, Alexander N Katchman, Joseph Bayne

J Clin Invest· January 2016

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The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart.
Lin Yang, Alexander Katchman, Richard L Weinberg, Jeffrey Abrams, Tahmina Samad

J Biol Chem· January 2015

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β-adrenergic regulation of the L-type Ca2+ channel does not require phosphorylation of α1C Ser1700.
Lin Yang, Alexander Katchman, Tahmina Samad, John Morrow, Richard Weinberg

Circ Res· September 2013

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Reduced vascular smooth muscle BK channel current underlies heart failure-induced vasoconstriction in mice.
Elaine Wan, Jared S Kushner, Sergey Zakharov, Xiao-Wei Nui, Neelesh Chudasama, Alexander Katchman

FASEB J· May 2013

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Mice with cardiac overexpression of peroxisome proliferator-activated receptor γ have impaired repolarization and spontaneous fatal ventricular arrhythmias.
John P Morrow, Alexander Katchman, Ni-Huiping Son, Chad M Trent, Raffay Khan

Circulation· December 2011

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Cardiac L-type calcium channel (Cav1.2) associates with gamma subunits.
Lin Yang, Alexander Katchman, John P Morrow, Darshan Doshi, Steven O Marx

FASEB J· March 2011

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Protein kinase C isoforms differentially phosphorylate Ca(v)1.2 alpha(1c).
Lin Yang, Darshan Doshi, John Morrow, Alexander Katchman, Xiang Chen

Biochemistry· July 2009

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Kcnq1 contributes to an adrenergic-sensitive steady-state K+ current in mouse heart.
Bjorn C Knollmann, Syevda Sirenko, Qi Rong, Alexander N Katchman, Mathew Casimiro

Biochem Biophys Res Commun· August 2007

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Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs.
Alexander N Katchman, John Koerner, Toshimasa Tosaka, Raymond L Woosley, Steven N Ebert

J Pharmacol Exp Ther· March 2006

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Intrinsic cardiac catecholamines help maintain beating activity in neonatal rat cardiomyocyte cultures.
Aruna R Natarajan, Qi Rong, Alexander N Katchman, Steven N Ebert

Pediatr Res· September 2004

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Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient neonatal mice: possible roles for human-like Kcnq1 isoform 1 and slow delayed rectifier K+ current.
Bjorn C Knollmann, Mathew C Casimiro, Alexander N Katchman, Syevda G Sirenko, Tilmann Schober

J Pharmacol Exp Ther· July 2004

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QTc interval prolongation associated with intravenous methadone.
Craig A Kornick, Michael J Kilborn, Juan Santiago-Palma, Glenn Schulman, Howard T Thaler, Alexander N Katchman

Pain· October 2003

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Nicotine induces a long QT phenotype in Kcnq1-deficient mouse hearts.
Toshimasa Tosaka, Mathew C Casimiro, Qi Rong, Srihari Tella, Michelle Oh, Alexander N Katchman

J Pharmacol Exp Ther· September 2003

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