Publications by authors named "Alexander Nickel"

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Hypercontractility and Oxidative Stress Drive Creatine Kinase Dysfunction in Hypertrophic Cardiomyopathy.
Anton Xu, David Weissman, Katharina J Ermer, Edoardo Bertero, Jan M Federspiel, Alexander G Nickel

Circulation· December 2025

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From kidney injury to cardiac dysfunction: the central role of oxidative stress in diabetes and CKD.
Payel Sen, Theresa Sittig, Jules Hamers, Laura d'Ambrosio, Irem Ornek, Alexander G Nickel

Basic Res Cardiol· December 2025

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Calmodulin enhancement of mitochondrial calcium uniporter function in isolated mitochondria.
Sara A Garcia, Anne M Neumaier, Michael Kohlhaas, Anton Xu, Alexander Nickel

Cell Calcium· November 2025

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Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation.
Julius Ryan D Pronto, Fleur E Mason, Eva A Rog-Zielinska, Funsho E Fakuade, Donata Bülow, Alexander Nickel

Circ Res· November 2025

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Interferon gamma signaling drives cardiac metabolic rewiring.
Ebram Tharwat Melika, DiyaaElDin Ashour, Kyoungmin Kim, Alexander Nickel, Paula Arias-Loza

bioRxiv· September 2025

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Mitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF.
Mark E Pepin, Philipp J M Konrad, Sumra Nazir, Farhad Bazgir, Christoph Maack, Alexander Nickel

Circ Res· June 2025

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Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet-induced obesity.
Vasco Sequeira, Julia Theisen, Katharina J Ermer, Marie Oertel, Anton Xu, Alexander Nickel

ESC Heart Fail· April 2025

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Gpr55 deficiency crucially alters cardiomyocyte homeostasis and counteracts angiotensin II induced maladaption in female mice.
Brigitte Schopohl, Michael Kohlhaas, Alexander G Nickel, Anna-Florentine Schiuma, Sanne L Maas

Br J Pharmacol· February 2025

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GLP-1 and PYY for the treatment of obesity: a pilot study on the use of agonists and antagonists in diet-induced rats.
Marie Oertel, Christian G Ziegler, Michael Kohlhaas, Alexander Nickel, Simon Kloock

Endocr Connect· March 2024

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Epigenetic modulators link mitochondrial redox homeostasis to cardiac function in a sex-dependent manner.
Zaher ElBeck, Mohammad Bakhtiar Hossain, Humam Siga, Nikolay Oskolkov, Fredrik Karlsson, Alexander G Nickel

Nat Commun· March 2024

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Effects of NPY-2 Receptor Antagonists, Semaglutide, PYY, and Empagliflozin on Early MASLD in Diet-Induced Obese Rats.
Simon Kloock, Niklas Haerting, Gloria Herzog, Marie Oertel, Niklas Geiger, Alexander Nickel

Nutrients· March 2024

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Mutations in DNAJC19 cause altered mitochondrial structure and increased mitochondrial respiration in human iPSC-derived cardiomyocytes.
Anna Janz, Katharina Walz, Alexandra Cirnu, Jessica Surjanto, Daniela Urlaub, Alexander Nickel

Mol Metab· January 2024

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Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome.
Ilona Kutschka, Edoardo Bertero, Christina Wasmus, Ke Xiao, Lifeng Yang, Alexander Nickel

Basic Res Cardiol· November 2023

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An arrhythmogenic metabolite in atrial fibrillation.
Julia Krause, Alexander Nickel, Alexandra Madsen, Hamish M Aitken-Buck, A M Stella Stoter

J Transl Med· August 2023

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Mechanistic Insights of the LEMD2 p.L13R Mutation and Its Role in Cardiomyopathy.
Ruping Chen, Simone Buchmann, Amos Kroth, Anahi-Paula Arias-Loza, Michael Kohlhaas, Alexander Nickel

Circ Res· January 2023

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TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy.
Li Zhang, Felicia Dietsche, Bruno Seitaj, Liliana Rojas-Charry, Nadina Latchman, Alexander Nickel

Life Sci Alliance· October 2022

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Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions.
Michael G Paulus, Kathrin Renner, Alexander G Nickel, Christoph Brochhausen, Katharina Limm

Basic Res Cardiol· September 2022

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Metabolic alterations in a rat model of takotsubo syndrome.
Nadine Godsman, Michael Kohlhaas, Alexander Nickel, Lesley Cheyne, Marco Mingarelli

Cardiovasc Res· June 2022

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Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca2+ cycling.
Senka Ljubojević-Holzer, Simon Kraler, Nataša Djalinac, Mahmoud Abdellatif, Julia Voglhuber, Alexander Nickel

Cardiovasc Res· May 2022

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Genetic Ablation of the Mitochondrial Calcium Uniporter (MCU) Does not Impair T Cell-Mediated Immunity .
Hao Wu, Benjamin Brand, Miriam Eckstein, Sophia M Hochrein, Magdalena Shumanska, Alexander Nickel

Front Pharmacol· December 2021

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Loss of Mitochondrial Ca Uniporter Limits Inotropic Reserve and Provides Trigger and Substrate for Arrhythmias in Barth Syndrome Cardiomyopathy.
Edoardo Bertero, Alexander Nickel, Michael Kohlhaas, Mathias Hohl, Vasco Sequeira

Circulation· November 2021

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Repeated exposure to transient obstructive sleep apnea-related conditions causes an atrial fibrillation substrate in a chronic rat model.
Benedikt Linz, Mathias Hohl, Lisa Lang, Dickson W L Wong, Alexander G Nickel

Heart Rhythm· March 2021

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Heart-Microcirculation Connection: Effects of ANP (Atrial Natriuretic Peptide) on Pericytes Participate in the Acute and Chronic Regulation of Arterial Blood Pressure.
Katarina Špiranec Spes, Wen Chen, Lisa Krebes, Katharina Völker, Marco Abeßer, Alexander Nickel

Hypertension· November 2020

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Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx).
Christine M Loescher, Martin Breitkreuz, Yong Li, Alexander Nickel, Andreas Unger

Proc Natl Acad Sci U S A· September 2020

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Selective NADH communication from α-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart.
Michael Wagner, Edoardo Bertero, Alexander Nickel, Michael Kohlhaas, Gary E Gibson

Basic Res Cardiol· August 2020

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