Publications by authors named "Alexander P Clark"

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MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis.
Jonathon M Muncie-Vasic, Tanvi Sinha, Alexander P Clark, Emily F Brower, Jeffrey J Saucerman

Genes Dev· December 2025

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Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease.
Irfan S Kathiriya, Kavitha S Rao, Alexander P Clark, Kevin M Hu, Zoe L Grant

Development· December 2025

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Reduced TBX5 dosage undermines developmental control of atrial cardiomyocyte identity in a model of human atrial disease.
Irfan S Kathiriya, Kavitha S Rao, Alexander P Clark, Kevin M Hu, Zoe L Grant

bioRxiv· November 2025

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Resolving Artifacts in Voltage-Clamp Experiments with Computational Modeling: An Application to Fast Sodium Current Recordings.
Chon Lok Lei, Alexander P Clark, Michael Clerx, Siyu Wei, Meye Bloothooft

Adv Sci (Weinh)· August 2025

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Logic-based modeling of biological networks with Netflux.
Alexander P Clark, Mukti Chowkwale, Alexander Paap, Stephen Dang, Jeffrey J Saucerman

PLoS Comput Biol· April 2025

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MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis.
Jonathon M Muncie-Vasic, Tanvi Sinha, Alexander P Clark, Emily F Brower, Jeffrey J Saucerman

bioRxiv· March 2025

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Logic-based modeling of biological networks with Netflux.
Alexander P Clark, Mukti Chowkwale, Alexander Paap, Stephen Dang, Jeffrey J Saucerman

bioRxiv· November 2024

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Stem cell-derived cardiomyocyte heterogeneity confounds electrophysiological insights.
Alexander P Clark, Trine Krogh-Madsen, David J Christini

J Physiol· October 2024

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Single-cell ionic current phenotyping elucidates non-canonical features and predictive potential of cardiomyocytes during automated drug experiments.
Alexander P Clark, Siyu Wei, David J Christini, Trine Krogh-Madsen

J Physiol· October 2024

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Resolving artefacts in voltage-clamp experiments with computational modelling: an application to fast sodium current recordings.
Chon Lok Lei, Alexander P Clark, Michael Clerx, Siyu Wei, Meye Bloothooft

bioRxiv· July 2024

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Single-cell ionic current phenotyping explains stem cell-derived cardiomyocyte action potential morphology.
Alexander P Clark, Siyu Wei, Kristin Fullerton, Trine Krogh-Madsen, David J Christini

Am J Physiol Heart Circ Physiol· May 2024

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Optimization of a cardiomyocyte model illuminates role of increased in repolarization reserve.
Kristin E Fullerton, Alexander P Clark, Trine Krogh-Madsen, David J Christini

Am J Physiol Heart Circ Physiol· February 2024

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Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings.
Alexander P Clark, Michael Clerx, Siyu Wei, Chon Lok Lei, Teun P de Boer

Europace· August 2023

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Rapid ionic current phenotyping (RICP) identifies mechanistic underpinnings of iPSC-CM AP heterogeneity.
Alexander P Clark, Siyu Wei, Kristin Fullerton, Trine Krogh-Madsen, David J Christini

bioRxiv· August 2023

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An in silico-in vitro pipeline for drug cardiotoxicity screening identifies ionic pro-arrhythmia mechanisms.
Alexander P Clark, Siyu Wei, Darshan Kalola, Trine Krogh-Madsen, David J Christini

Br J Pharmacol· October 2022

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Comparison of quantitative wall-motion analysis and strain for detection of coronary stenosis with three-dimensional dobutamine stress echocardiography.
Katherine M Parker, Alexander P Clark, Norman C Goodman, David K Glover, Jeffrey W Holmes

Echocardiography· February 2015

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