Publications by authors named "Alexander Pautsch"

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Structural basis of allosteric and bitopic ligands binding in sphingosine-1-phosphate receptors 2 and 3.
Yanhong Wu, Qiuru Chen, Hongyu Wang, Kezhen Liu, Jiaxin Wei, Alexander Pautsch

Protein Cell· August 2025

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Structural basis of the mechanism and inhibition of a human ceramide synthase.
Tomas C Pascoa, Ashley C W Pike, Christofer S Tautermann, Gamma Chi, Michael Traub, Alexander Pautsch

Nat Struct Mol Biol· March 2025

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Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability.
Niklas Heine, Alexander Weber, Alexander Pautsch, Dirk Gottschling, Ingo Uphues

Bioorg Med Chem Lett· November 2024

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Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design.
Rebecca Ebenhoch, Margit Bauer, Helmut Romig, Dirk Gottschling, Jörg Thomas Kley, Alexander Pautsch

Acta Crystallogr D Struct Biol· October 2023

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Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1.
Tânia F Custódio, Maxime Killer, Dingquan Yu, Virginia Puente, Daniel P Teufel, Alexander Pautsch

Nat Commun· September 2023

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Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism.
Sven O Dahms, Gisela Schnapp, Martin Winter, Frank H Büttner, Marco Schlepütz, Alexander Pautsch

ACS Chem Biol· April 2022

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Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex.
Bin Huang, Qiang Guo, Marie L Niedermeier, Jingdong Cheng, Tatjana Engler, Alexander Pautsch

Structure· August 2021

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Covalent inhibitor reactivity prediction by the electrophilicity index-in and out of scope.
Markus R Hermann, Alexander Pautsch, Marc A Grundl, Alexander Weber, Christofer S Tautermann

J Comput Aided Mol Des· April 2021

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BIreactive: A Machine-Learning Model to Estimate Covalent Warhead Reactivity.
Ferruccio Palazzesi, Markus R Hermann, Marc A Grundl, Alexander Pautsch, Daniel Seeliger

J Chem Inf Model· June 2020

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A Fast Ab Initio Predictor Tool for Covalent Reactivity Estimation of Acrylamides.
Ferruccio Palazzesi, Marc A Grundl, Alexander Pautsch, Alexander Weber, Christofer S Tautermann

J Chem Inf Model· August 2019

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Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists.
Anna-Katharina Apel, Robert K Y Cheng, Christofer S Tautermann, Michael Brauchle, Chia-Ying Huang, Alexander Pautsch

Structure· March 2019

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The cryo-electron microscopy structure of huntingtin.
Qiang Guo, Bin Huang, Jingdong Cheng, Manuel Seefelder, Tatjana Engler, Alexander Pautsch

Nature· March 2018

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Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.
Sebastian Mathea, Kamal R Abdul Azeez, Eidarus Salah, Cynthia Tallant, Finn Wolfreys, Alexander Pautsch

ACS Chem Biol· June 2016

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Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis.
Lutz Wollin, Eva Wex, Alexander Pautsch, Gisela Schnapp, Katrin E Hostettler

Eur Respir J· May 2015

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Fast native-SAD phasing for routine macromolecular structure determination.
Tobias Weinert, Vincent Olieric, Sandro Waltersperger, Ezequiel Panepucci, Lirong Chen, Alexander Pautsch

Nat Methods· February 2015

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Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy.
Dianfan Li, Nicole Howe, Abhiram Dukkipati, Syed T A Shah, Benjamin D Bax, Alexander Pautsch

Cryst Growth Des· April 2014

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Crystal structure of glucokinase regulatory protein.
Alexander Pautsch, Nadja Stadler, Adelheid Löhle, Wolfgang Rist, Adina Berg

Biochemistry· May 2013

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A systematic approach to increase the efficiency of membrane protein production in cell-free expression systems.
Stefan Haberstock, Christian Roos, Yvette Hoevels, Volker Dötsch, Gisela Schnapp, Alexander Pautsch

Protein Expr Purif· April 2012

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The Implication of the First Agonist Bound Activated GPCR X-ray Structure on GPCR in Silico Modeling.
Christofer S Tautermann, Alexander Pautsch

ACS Med Chem Lett· June 2011

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Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.
Søren G F Rasmussen, Hee-Jung Choi, Juan Jose Fung, Els Pardon, Paola Casarosa, Alexander Pautsch

Nature· January 2011

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Molecular recognition of the protein phosphatase 1 glycogen targeting subunit by glycogen phosphorylase.
Alexander Pautsch, Nadja Stadler, Oliver Wissdorf, Elke Langkopf, Werner Moreth

J Biol Chem· April 2008

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C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins.
Martin Vogelsgesang, Alexander Pautsch, Klaus Aktories

Naunyn Schmiedebergs Arch Pharmacol· February 2007

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Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme.
Alexander Pautsch, Martin Vogelsgesang, Jens Tränkle, Christian Herrmann, Klaus Aktories

EMBO J· October 2005

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