Publications by authors named "Alexander Pearson"

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Bmi-1 inhibition sensitizes head and neck cancer stem cells to cytotoxic chemotherapy.
Alexandra E Herzog, Shirley Zheng, Kristy A Warner, Jaqueline V Vanini, Ritu Somayaji, Alexander T Pearson

Transl Oncol· January 2026

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Professionalism in Residency Training: The Learning Environment for Professionalism Survey.
Anna Byszewski, Alexander Pearson, Heather Lochnan, Donna L Johnston, Sharon Whiting

Eval Health Prof· December 2025

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Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche.
Weijie Guo, Jingyun Luan, Xuejie Huang, Daniel Leon, Sophie Gang, Alexander T Pearson

Cancer Cell· December 2025

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Deep Learning Discriminates Thymic Epithelial Tumors Histological Subtypes Using Digital Pathology.
Matteo Sacco, Erica Pietroluongo, Anna Di Lello, Mirella Marino, Alexander McGeough, Alexander T Pearson

Ann Oncol· December 2025

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Corrigendum to "Analysis of AI foundation model features decodes the histopathologic landscape of HPV-positive head and neck squamous cell carcinomas". [Oral Oncol. 163 (2025) 107207].
Hanna M Hieromnimon, Anna Trzcinska, Frank T Wen, Frederick M Howard, James M Dolezal, Alexander T Pearson

Oral Oncol· October 2025

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Virtual multiplex immunofluorescence identifies lymphocyte subsets predictive of response to neoadjuvant therapy.
Anran Li, Madeleine Torcasso, Anna Woodard, Hanna Hieromnimon, Jonathan Trujillo, Alexander T Pearson

Ther Adv Med Oncol· October 2025

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Machine learning models for predicting recurrence and malignant transformation of oral leukoplakia.
Caique Mariano Pedroso, Anderson Faria Claret, Rafael Vasconcelos Costa Machado, Anna Luiza Damaceno Araujo, Cristina Saldivia-Siracusa, Alexander T Pearson

Oral Surg Oral Med Oral Pathol Oral Radiol· September 2025

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Early Dynamics of Circulating Tumor HPV-DNA with Neoadjuvant Chemotherapy and Response-Adapted De-escalation in Human Papillomavirus-Associated Oropharyngeal Cancer.
Ari J Rosenberg, Evgeny Izumchenko, Aditya Juloori, Rohan Katipally, John Cursio, Alexander T Pearson

Clin Cancer Res· August 2025

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Analytical and clinical performance validation of HPV-SEQ, a novel NGS-based liquid biopsy platform for detection and quantification of human papilloma virus circulating tumor DNA.
Samaneh Eickelschulte, Anna Starus, David H Murray, Kirsten A Keyser, Oliver Schauer, Alexander T Pearson

Oral Oncol· August 2025

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Building digital histology models of transcriptional tumor programs with generative deep learning for pathology-based precision medicine.
Hanna M Hieromnimon, James Dolezal, Kristina Doytcheva, Frederick M Howard, Sara Kochanny, Alexander T Pearson

Genome Med· August 2025

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Integration of Gene Expression and Digital Histology to Predict Treatment-Specific Responses in Breast Cancer.
Frederick M Howard, James Dolezal, Hanna Hieromnimon, Sara Venters, Sara Kochanny, Alexander T Pearson

medRxiv· August 2025

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Counterfactual Diffusion Models for Interpretable Morphology-based Explanations of Artificial Intelligence Models in Pathology.
Laura Žigutytė, Tim Lenz, Tianyu Han, Katherine J Hewitt, Nic G Reitsam, Alexander T Pearson

bioRxiv· July 2025

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Tumor-intrinsic and immune-related features associated with treatment failure in human papillomavirus-related oropharyngeal cancer.
Malay K Sannigrahi, Lovely Raghav, Dominick J Rich, Travis P Schrank, Joseph A Califano, Alexander T Pearson

J Natl Cancer Inst· July 2025

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Automated classification of oral potentially malignant disorders and oral squamous cell carcinoma using a convolutional neural network framework: a cross-sectional study.
Cristina Saldivia-Siracusa, Eduardo Santos Carlos de Souza, Arnaldo Vitor Barros da Silva, Anna Luíza Damaceno Araújo, Caíque Mariano Pedroso, Alexander T Pearson

Lancet Reg Health Am· July 2025

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End-to-end prediction of clinical outcomes in head and neck squamous cell carcinoma with foundation model-based multiple instance learning.
Asier Rabasco Meneghetti, Marta Ligero Hernández, Jens-Peter Kühn, Steffen Löck, Zunamys Itzell Carrero, Alexander T Pearson

BMC Artif Intell· June 2025

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Neoadjuvant Nivolumab Plus Chemotherapy Followed by Response-Stratified Chemoradiation Therapy in HPV-Negative Head and Neck Cancer: The DEPEND Phase 2 Nonrandomized Clinical Trial.
Ari J Rosenberg, Aditya Juloori, Michael J Jelinek, Nishant Agrawal, John F Cursio, Alexander T Pearson

JAMA Oncol· May 2025

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Deep Learning on Histopathological Images to Predict Breast Cancer Recurrence Risk and Chemotherapy Benefit.
Gil Shamai, Shachar Cohen, Yoav Binenbaum, Edmond Sabo, Alexandra Cretu, Alexander T Pearson

medRxiv· May 2025

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Analysis of AI foundation model features decodes the histopathologic landscape of HPV-positive head and neck squamous cell carcinomas.
Hanna M Hieromnimon, Anna Trzcinska, Frank T Wen, Frederick M Howard, James M Dolezal, Alexander T Pearson

Oral Oncol· April 2025

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Artificial intelligence and the diagnosis of oral cavity cancer and oral potentially malignant disorders from clinical photographs: a narrative review.
Payam Mirfendereski, Grace Y Li, Alexander T Pearson, Alexander Ross Kerr

Front Oral Health· March 2025

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PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands.
Vasudha Mishra, Alka Singh, Michael Korzinkin, Xiangying Cheng, Claudia Wing, Alexander T Pearson

J Exp Clin Cancer Res· January 2025

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End-to-end prediction of clinical outcomes in head and neck squamous cell carcinoma with foundation model-based multiple instance learning.
Asier Rabasco Meneghetti, Marta Ligero Hernández, Jens-Peter Kuehn, Steffen Löck, Zunamys Itzel Carrero, Alexander T Pearson

medRxiv· January 2025

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Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology.
Siddhi Ramesh, Emma Dyer, Monica Pomaville, Kristina Doytcheva, James Dolezal, Alexander T Pearson

NPJ Precis Oncol· November 2024

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Generative adversarial networks accurately reconstruct pan-cancer histology from pathologic, genomic, and radiographic latent features.
Frederick M Howard, Hanna M Hieromnimon, Siddhi Ramesh, James Dolezal, Sara Kochanny, Alexander T Pearson

Sci Adv· November 2024

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Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instability.
Malay K Sannigrahi, Lovely Raghav, Dominick J Rich, Travis P Schrank, Joseph A Califano, Alexander T Pearson

bioRxiv· November 2024

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Agent-Based Modeling of Virtual Tumors Reveals the Critical Influence of Microenvironmental Complexity on Immunotherapy Efficacy.
Yixuan Wang, Daniel R Bergman, Erica Trujillo, Anthony A Fernald, Lie Li, Alexander T Pearson

Cancers (Basel)· August 2024

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