Publications by authors named "Alexander Skeldon"

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Structural insight into the cGAS active site explains differences between therapeutically relevant species.
Alexander M Skeldon, Li Wang, Nicolas Sgarioto, Ramsay E Beveridge, Silas Chan

Commun Chem· March 2025

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Discovery of Potent and Orally Bioavailable Pyrimidine Amide cGAS Inhibitors via Structure-Guided Hybridization.
Patrick Cyr, Lee D Fader, Jason D Burch, Kelly A Pike, Daniel V Sietsema, Alexander M Skeldon

ACS Med Chem Lett· December 2024

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Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500).
W Cameron Black, Abbas Abdoli, Xiuli An, Anick Auger, Patrick Beaulieu, Alexander Skeldon

J Med Chem· February 2024

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Guiding ATR and PARP inhibitor combinationswith chemogenomic screens.
Michal Zimmermann, Cynthia Bernier, Beatrice Kaiser, Sara Fournier, Li Li, Alexander Skeldon

Cell Rep· July 2022

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RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors.
Anne Roulston, Michal Zimmermann, Robert Papp, Alexander Skeldon, Charles Pellerin

Mol Cancer Ther· February 2022

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Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.
Alexander M Skeldon, Alexandre Morizot, Todd Douglas, Nicola Santoro, Romy Kursawe

J Immunol· January 2016

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Caspases and inflammasomes in metabolic inflammation.
Alexander M Skeldon, May Faraj, Maya Saleh

Immunol Cell Biol· April 2014

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Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival.
Ian Gaël Rodrigue-Gervais, Katherine Labbé, Maryse Dagenais, Jeremy Dupaul-Chicoine, Claudia Champagne, Alexander Skeldon

Cell Host Microbe· January 2014

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The Type VI secretion system of Burkholderia cenocepacia affects multiple Rho family GTPases disrupting the actin cytoskeleton and the assembly of NADPH oxidase complex in macrophages.
Roberto Rosales-Reyes, Alexander M Skeldon, Daniel F Aubert, Miguel A Valvano

Cell Microbiol· February 2012

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The inflammasomes: molecular effectors of host resistance against bacterial, viral, parasitic, and fungal infections.
Alexander Skeldon, Maya Saleh

Front Microbiol· July 2011

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Construction of aminoglycoside-sensitive Burkholderia cenocepacia strains for use in studies of intracellular bacteria with the gentamicin protection assay.
Mohamad A Hamad, Alexander M Skeldon, Miguel A Valvano

Appl Environ Microbiol· May 2010

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